Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Mucosal turnover in the duodenum and the jejunum following different diets at T1 and T2 post-weaning periods. by Marcella Massimini (5678543)

Supplementary Figs 1–7. by Juliane F. Tampé (19976538)

Changes in the active H3K27ac and repressive H3K27me3 histone marks among Vasa2+/Piwi1+ and all cells in fed, starved, and refed juvenile polyps. by Eudald Pascual-Carreras (12115380)

“…Between fed, T_5ds and T_20ds timepoints, MFI levels of H3K27ac progressively and significantly decreased while levels H3K27me3 (M) did not change significantly (N). …”

Dynamics of EGFP and mRFP fluorescence in infected cells under different heat shock conditions. by Enrique Paz-Cortés (20988196)

Risk of bias summary. by Duc Tran Quang (20564967)

“…The observed decrease in body weight could be partially attributed to factors influencing energy balance, as evidenced by the significantly lower mean calorie intake at the end of the intervention (1694.71 kcal/day, 95% CI: 1498.57–1890.85) compared to the baseline intake (2000.64 kcal/day, 95% CI: 1830–2172.98), despite the absence of intentional efforts to restrict energy intake by the participants. …”

Criteria for study selection. by Duc Tran Quang (20564967)

“…The observed decrease in body weight could be partially attributed to factors influencing energy balance, as evidenced by the significantly lower mean calorie intake at the end of the intervention (1694.71 kcal/day, 95% CI: 1498.57–1890.85) compared to the baseline intake (2000.64 kcal/day, 95% CI: 1830–2172.98), despite the absence of intentional efforts to restrict energy intake by the participants. …”

Treatment of cancer cells with vitamin D3 induced death <i>a.</i> by Vidya G. Bettada (22208808)

Effect of alkali-stress to chlorophyll fluorescence parameters compared to control treatment. by Zeyu Jiang (5094320)

Effect of alkali-stress on photosynthetic pigments of hemp seedlings compared to control treatment. by Zeyu Jiang (5094320)

Effect of alkali-stress on physiological indices of antioxidant system compared to control treatment. by Zeyu Jiang (5094320)

Baseline characteristics and oxidative profiling. by Summan Thahiem (20988319)

Effect of Viscosol on upstream mediators of inflammasomes activation, PTP1B and inflammasome complexes. by Summan Thahiem (20988319)

The expression profile of lipogenic genes, oxidative stress mediators as well as UPR^ER and mitochondrial stress markers. by Summan Thahiem (20988319)

Effect of Viscosol on the expression of inflammatory cytokines, chemokines as well as cell death pathways. by Summan Thahiem (20988319)

“…The results shown are represented as mean ±  SD. Significant differences compared to control (****<i>p</i> < 0.0001, ***<i>p</i> < 0.0001, **<i>p</i> < 0.01 and * <i>p</i> <  0.05; two-wayANOVA and Tukey’s test).…”

Dynamics and functional role of TOR signaling during cell cycle re-entry in Vasa2+/Piwi1+ cells after refeeding. by Eudald Pascual-Carreras (12115380)

Effect of imidacloprid and rutin administration on wet mass, dry mass, and water content of the thorax in Africanized honey bee foragers. by Juan P. Hernández (22216133)

Effect of imidacloprid (Im) and rutin (Ru) administration on thoracic electric currents in Africanized honey bee foragers. by Juan P. Hernández (22216133)

Effect of imidacloprid (Im) and rutin (Ru) administration on evaporation dynamics of extracellular fluid (ECF) extracted from thoraxes of Africanized honey bee foragers. by Juan P. Hernández (22216133)