<b>Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional </b><b><i>WFS1</i></b><b> varian... by Silvia Torchio (611349)

“…Pancreatic β cells obtained from patient-derived induced Pluripotent Stem Cells (iPSCs) carrying this <i>WFS1 </i>variant exhibited reduced insulin processing and impaired secretory granule maturation, as evidenced by proinsulin accumulation and decreased prohormone convertase PC1/3. Moreover, they exhibited dysregulated Ca²⁺ fluxes due to altered transcription of Ca²⁺-related genes, including <i>CACNA1D</i>, and significantly reduced <i>SNAP25</i> levels, leading to uncoordinated oscillations and poor glucose responsiveness. …”

DataSheet1_Association between changes in thyroid hormones and incident type 2 diabetes using joint models of longitudinal and time-to-event data: more than a decade follow up in t... by Alireza Amirabadizadeh (6399635)

“…Background<p>Type 2 diabetes mellitus (T2DM) poses a significant public health challenge, contributing to considerable morbidity and mortality worldwide, which necessitates urgent preventive measures. …”

Map of the Comacchio Lagoon. by Katalin Patonai (11465287)

“…However, they are subject to significant stressors, both natural and anthropogenic, which can alter ecosystem services and functioning and food web structure. …”

Sampling scenarios used in our experiments. by Anna Beatriz Silva (20989245)

“…<div><p>Premature birth can be defined as birth before 37 weeks of gestation, which is a significant global health issue, being the main cause for neonatal deaths. …”

Hybridsampling triple size models performance. by Anna Beatriz Silva (20989245)

“…<div><p>Premature birth can be defined as birth before 37 weeks of gestation, which is a significant global health issue, being the main cause for neonatal deaths. …”

Glucagon-like peptide 1 receptor agonists modestly reduced low-density lipoprotein cholesterol and total cholesterol levels independent of weight reduction: a meta-analysis and met... by Frederick Berro Rivera (12679463)

“…</p> <p>GLP-1RA treatment modestly decreased LDL-C and TC but did not significantly affect triglycerides, VLDL-C, or HDL-C.…”

Table 1_Danggui Buxue Decoction attenuates 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone—induced lung cancer growth in A/J mice by suppressing HIF-1α/VEGF-mediated angiogenesis.do... by Wu Chen (569414)

“…Despite this, current anti-angiogenic therapies face significant clinical limitations. Danggui Buxue Decoction (DBD), a traditional Chinese herbal formula used to tonify Qi and activate blood circulation, exhibits clinical potential in delaying LC progression; however, its precise mechanistic basis remains incompletely defined. …”

Sample means, SDs, and selected correlations. by Erik Lykke Mortensen (7239170)

“…Educational attainment was a particularly strong predictor of status attainment. …”

Data Sheet 1_Mechanisms underlying the wound healing and tissue regeneration properties of a novel gauze dressing impregnated with traditional herbal medicine (Ya-Samarn-Phlae) in... by Sineenart Sanpinit (14836963)

“…</p>Results<p>During the 6-month storage period, the α-mangostin content measured in YaSP did not decrease; however, the curcumin level showed a significant reduction. …”

BMI versus change in soft tissue thickness in hydrated to dehydrated state. by Fatemeh Khorami (22041563)

Data Sheet 1_Global, regional, and national trends in ischaemic stroke burden and risk factors among adults aged 20 + years (1990–2021): a systematic analysis of data from the Glob... by Sibo Liu (9975065)

“…Males consistently faced a greater burden of IS across all subgroups. High systolic blood pressure and high low-density lipoprotein cholesterol (LDL-C) levels consistently represented the most significant risk factors contributing to DALYs from 1990 to 2021.…”

Bird’s own song is similarly represented by NCM neurons when sung or played back a) Schematic of behavioral contexts. b-e) Effect of behavioral context on response properties of ne... by Daniel J. Pollak (14593065)

Table 1_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden... by Jiaoli Xu (20871584)

“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”

Image 1_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden... by Jiaoli Xu (20871584)

“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”

Table 2_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden... by Jiaoli Xu (20871584)

“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”

Table 4_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden... by Jiaoli Xu (20871584)

“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”

Table 3_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden... by Jiaoli Xu (20871584)

“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”

Image 2_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden... by Jiaoli Xu (20871584)

“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”

Data Sheet 1_Global, regional, and national burden of interstitial lung disease in middle-aged and older adults from 1990 to 2021 with projections to 2050: a systematic analysis of... by Long Chen (315739)

“…Background<p>Interstitial lung disease (ILD) constitutes a significant global health challenge. However, existing epidemiological studies predominantly focus on worldwide and regional distribution patterns, while a substantial knowledge gap persists regarding the epidemiological characteristics of ILD among middle-aged and older adults (50–74 years). …”

Data Sheet 1_Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in hum... by William D. Tolbert (7870697)

“…Its affinity for IgG and ability to mediate ADCP is influenced by allelic polymorphisms. In humans, a single amino acid polymorphism at position 131, where histidine (H) is substituted with arginine (R), leads to decreased IgG1 and IgG2 subclass binding affinity and, consequently, lower efficiency of phagocytic responses. …”