Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms حسب Farman M. Abbasi (22318766)

"…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms حسب Farman M. Abbasi (22318766)

"…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"

Effect of glucose and efflux pump inhibitors on the efflux of ethidium bromide by <i>Mycobacterium abscessus</i>. حسب Timilehin Faboro (20175963)

SLC response kinematics at 28 dpf. حسب Morgan Barnes (7876373)

"…For those we utilized a Welch’s t-test. Asterisks denote statistical significances as listed above in legend.…"

Transcript response differences between T1R and LEP patients for GO terms, KEGG or Reactome pathways that showed significant enrichment for both the LEP and T1R groups. حسب Wilian Correa-Macedo (11813183)

"…<p>Immune response-linked terms for which the 5639 overlapping up-regulated DET presented in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0011866#pntd.0011866.g002" target="_blank">Fig 2D and 2E</a> were significantly enriched. …"

Cytochrome bd-II oxidase CyxA promotes the pathogenicity of <i>Klebsiella pneumoniae</i> by resisting oxidative stress حسب Xiao Xiao (99147)

"…Additionally, the expression levels of <i>cyxA</i> at 37°C and 41°C were significantly higher compared to 30°C, and the Δ<i>cyxA</i> strain exhibited significantly lower viable counts, elevated intracellular reactive oxygen species (ROS) levels, and decreased total antioxidant capacity (T-AOC) relative to WT at 37°C and 41°C. …"

Composition of experimental diets fed to cherry shrimp (<i>N</i>. <i>davidi</i> var. red) including varying concentrations of astaxanthin and <i>Bidens pilosa</i> extract over a 8-... حسب Wei-Wei Hou (3405947)

Superimposed structures of AKT2 native (green color) and mutant (red color) models to visualize the stereochemical conformation of wild type and mutant residues at (a) 274, (b) 265... حسب Sadia Afrin Runa (22504971)

List of captured wild pollinator species. حسب Carmelo Gómez-Martínez (9384385)

"…We found that orchards surrounded by a greater proportion of natural landcover received more visits by wild bees and butterflies and fewer by honeybees. …"

Map of the 20 study orchards. حسب Carmelo Gómez-Martínez (9384385)

"…We found that orchards surrounded by a greater proportion of natural landcover received more visits by wild bees and butterflies and fewer by honeybees. …"

Pictures of carob tree flowers and orchard. حسب Carmelo Gómez-Martínez (9384385)

"…We found that orchards surrounded by a greater proportion of natural landcover received more visits by wild bees and butterflies and fewer by honeybees. …"

Estimating the transportation cost matrix from microstate joint probability of consecutive timesteps at rest. حسب Giacomo Barzon (19832364)

Levels of antioxidant enzymes (A) Catalase, (B) Superoxide dismutase, (C) peroxidase. حسب Hammad Ismail (4227988)

Transcriptomic data of mature adipocytes from Dbc1 KO vs WT mice حسب Leonardo Santos (477304)

"…<b>(D)</b> Emapplot of the top 50 significantly enriched Gene Ontology terms (Biological Process), with increased terms in red and decreased terms in blue, in Dbc1 KO compared to Dbc1^LoxP/LoxP. …"

Event-free survival analysis of microvascular outcome. حسب Clemens Plattner (21567706)

Event-free survival analysis of macrovascular outcome. حسب Clemens Plattner (21567706)

Inhibition of PGAM5 and apoptosis prevented <i>T. spiralis</i> larval invasion of Caco-2 monolayer. حسب Qi Qi Lu (17721401)

Volume distribution and sentiment of positive, negative, and neutral tweets. حسب Yuqi Zhang (286958)

Monthly volume distribution and sentiment score of five topic groups. حسب Yuqi Zhang (286958)

Growth of Sf14 in various media. حسب Nykki D. Ross (20933968)