Discovery of <i>N</i>‑(1,3,4-Thiadiazol-2-yl)amide Derivatives as Uncompetitive Inhibitors of 6‑Phosphogluconate Dehydrogenase by Rong Zhang (44942)

“…Among them, <b>19n</b> exhibited significant potency against 6PGD with an IC₅₀ value of 5.1 ± 1.0 μM. …”

Identification of Key Genes. by Chen Wang (88408)

PDS and CEP inhibited DDX60-mediated promotion of CCHFV replication. by Yutong Sui (11151669)

Stop codon readthrough for tRNA modification gene deletion mutants. by Léo Hardy (22538036)

Details of the computational domain. by Ammar Nazeer (20928237)

“…Computation of hydrodynamic coefficients across spatial directions provides insight into loading impacts on performance. Significant efficiency reductions are observed, such as a decrease from 64% to 28% at 40 degrees for an advance ratio of 0.88. …”

Details of Grid Generation for Mesh independence. by Ammar Nazeer (20928237)

“…Computation of hydrodynamic coefficients across spatial directions provides insight into loading impacts on performance. Significant efficiency reductions are observed, such as a decrease from 64% to 28% at 40 degrees for an advance ratio of 0.88. …”

Numerical simulation parameters summary. by Ammar Nazeer (20928237)

“…Computation of hydrodynamic coefficients across spatial directions provides insight into loading impacts on performance. Significant efficiency reductions are observed, such as a decrease from 64% to 28% at 40 degrees for an advance ratio of 0.88. …”

Predicted behavioural expression of young (orange) and old (blue) individuals that do (treatment) or do not (control) receive an immune challenge. by Antoine Bour (20489426)

“…<p>(a) If an immune challenge causes sickness behaviour then we expect that young and old immune-challenged individuals will decrease their population-level average behavioural expression compared with controls with old individuals decreasing their behavioural expression more than young individuals. …”

Source data file. by Laura Mora-Bitria (20477525)

“…Our results were validated in an independent data set. We conclude that iKIRs significantly decrease HLA class II protective associations and suggest that iKIRs regulate CD4⁺ T cell responses in T1D.…”

Supporting data file. by Laura Mora-Bitria (20477525)

“…Our results were validated in an independent data set. We conclude that iKIRs significantly decrease HLA class II protective associations and suggest that iKIRs regulate CD4⁺ T cell responses in T1D.…”

Demographics by Country and Gender. by Deeviya Francis Xavier (21485043)

“…Regarding creative self-efficacy, we found gender-specific impacts, with male participants experiencing a decrease, contrary to our expectations. …”

Study Data. by Deeviya Francis Xavier (21485043)

“…Regarding creative self-efficacy, we found gender-specific impacts, with male participants experiencing a decrease, contrary to our expectations. …”

Dataset. by Nathan Mubiru (21627195)

“…In contrast, samples collected in plain serum tubes kept at room temperature and uncentrifuged, C-peptide and insulin levels decreased significantly to 51% (p = 0.006) and 62% (p = 0. 083) respectively, similarly insulin levels for centrifuged samples declined to 64% (p = 0.083). …”

Complementary conditioning measures in healthy subjects. by Gabriela Ribeiro (4748373)

“…<b>(I) Novelty</b> ratings significantly decreased from pre to post-conditioning (F_(1,51) = 10.2, <i>P</i> = 0.002; post hoc CS^-, <i>P</i> = 0.0001; post hoc CS⁺, <i>P</i> = 0.01) but similarly for both stimuli (F_{(1, 51)} = 0.17, <i>P</i> = 0.7; Interaction: F_{(1, 51)} = 1.1, <i>P</i> = 0.3). …”

Complementary conditioning measures across the clinical study groups. by Gabriela Ribeiro (4748373)

“…Post hoc tests showed significant decreases for the surgical group (<i>P</i> = 0.05), while in the remaining groups, results did not reach significance (Healthy, <i>P</i> = 0.4; Obese, <i>P</i> = 0.1). …”

Radiologic results of patients. by Han-Ting Shih (20880477)

“…</p><p>Results</p><p>Following MUKA, significant differences in the change in tibial plafond-talus angle (PTA) were observed between the groups, with the varus ankle group showing a change of -0.71 ±  0.82° and the valgus ankle group showing a change of 0.08 ±  0.94° (p <  0.001). …”

Anonymized data used for analysis. by Han-Ting Shih (20880477)

“…</p><p>Results</p><p>Following MUKA, significant differences in the change in tibial plafond-talus angle (PTA) were observed between the groups, with the varus ankle group showing a change of -0.71 ±  0.82° and the valgus ankle group showing a change of 0.08 ±  0.94° (p <  0.001). …”

Overview of annotated metabolites. by Yunfei Xu (3156420)

“…<div><p>Tea ranks among the top three most beloved non-alcoholic beverages worldwide and boasts significant economic and health benefits. In addition to <i>Camellia sinensis</i> (L.) …”

Population dynamics reflect intention-action binding. by Jean-Paul Noel (3072192)

Source data for Fig 2. by Qi Xu (134661)

“…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …”