Table 3_Sodium nitroprusside improves circulatory failure in rabbit acute pulmonary embolism combined with shock model possibly by enhancing NO release and inhibiting TLR4/NF-кB/HI... by Yuchan Zhou (10928151)

“…Pulmonary angiography showed that the mean pulmonary artery pressure increased significantly and the mean arterial pressure decreased significantly in the model group, which could be reversed by SNP treatment. …”

Data Sheet 2_Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantatio... by Man Han (8444859)

“…</p>Results<p>Compared with the CON group, mice in the CUMS group showed significant depressive-like behavior, pathological damage to the hippocampus and colon tissues, significant decrease in levels of 5-HT, DA, and BDNF in the hippocampus, significant increase in levels of IL-1β, IL-6, TNF-α, DAO, and LPS in serum, significant decrease in colonic tight junction protein expression, and significant increase in protein expression of TLR4, p-NF-κB, NLRP3, ASC, and IL-1β in the hippocampus (P < 0.01); Compared with the CUMS group, the FMT group could effectively improve the above situation (P < 0.05, P < 0.01), whose therapeutic effect was second only to the OGF group (P < 0.01), while ABX + OGF group did not show obvious therapeutic effect.…”

Data Sheet 1_Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantatio... by Man Han (8444859)

“…</p>Results<p>Compared with the CON group, mice in the CUMS group showed significant depressive-like behavior, pathological damage to the hippocampus and colon tissues, significant decrease in levels of 5-HT, DA, and BDNF in the hippocampus, significant increase in levels of IL-1β, IL-6, TNF-α, DAO, and LPS in serum, significant decrease in colonic tight junction protein expression, and significant increase in protein expression of TLR4, p-NF-κB, NLRP3, ASC, and IL-1β in the hippocampus (P < 0.01); Compared with the CUMS group, the FMT group could effectively improve the above situation (P < 0.05, P < 0.01), whose therapeutic effect was second only to the OGF group (P < 0.01), while ABX + OGF group did not show obvious therapeutic effect.…”

Table 1_Association between oxidative balance score and methylation cycle biomarkers in US adults: insights from the national health and nutrition examination survey.docx by Xuna Liu (16988607)

“…</p>Results<p>In a nationally representative cohort of US adults (mean age: 47.04 ± 0.25 years; 51.76% female), OBS demonstrated significant associations with key methylation cycle biomarkers. …”

Data Sheet 1_N6-methyladenosine RNA landscape in the aged mouse hearts.zip by Xia Jing (3255219)

“…</p>Results<p>The overall m6A level remained constant; however, the expression of the methyltransferase METTL14 and the demethyltransferase FTO were significantly upregulated in aged hearts. Knockdown of METTL14 alleviated H₂O₂-induced senescence phenotypes, as reflected by a reduction in the number of SA-β-gal positive cells and a decrease in p21 expression. …”

Data Sheet 2_N6-methyladenosine RNA landscape in the aged mouse hearts.zip by Xia Jing (3255219)

“…</p>Results<p>The overall m6A level remained constant; however, the expression of the methyltransferase METTL14 and the demethyltransferase FTO were significantly upregulated in aged hearts. Knockdown of METTL14 alleviated H₂O₂-induced senescence phenotypes, as reflected by a reduction in the number of SA-β-gal positive cells and a decrease in p21 expression. …”

Data Sheet 3_N6-methyladenosine RNA landscape in the aged mouse hearts.zip by Xia Jing (3255219)

“…</p>Results<p>The overall m6A level remained constant; however, the expression of the methyltransferase METTL14 and the demethyltransferase FTO were significantly upregulated in aged hearts. Knockdown of METTL14 alleviated H₂O₂-induced senescence phenotypes, as reflected by a reduction in the number of SA-β-gal positive cells and a decrease in p21 expression. …”

Data Sheet 4_N6-methyladenosine RNA landscape in the aged mouse hearts.pdf by Xia Jing (3255219)

“…</p>Results<p>The overall m6A level remained constant; however, the expression of the methyltransferase METTL14 and the demethyltransferase FTO were significantly upregulated in aged hearts. Knockdown of METTL14 alleviated H₂O₂-induced senescence phenotypes, as reflected by a reduction in the number of SA-β-gal positive cells and a decrease in p21 expression. …”

Table 1_Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients.xlsx by Xiaoyan Fu (5578187)

“…Post-chemotherapy, patients with positive responses demonstrated an increase in Clostridium and Microbacterium species, along with a decrease in Streptococcus and Neisseria. In contrast, no significant changes were observed in the microbiota of patients with poor chemotherapy responses. …”

<b>Keystone taxa and microbial network complexity, rather than diversity, sustain soil multifunctionality along an elevational gradient in a subtropical karst mountain</b> by Weixue Luo (6070040)

“…</a>Moreover, annual mean temperature and soil pH significantly influenced microbial characteristics, which in turn affected soil EMF. …”

Data Sheet 1_Breaking the cancer code: a novel DNA minicircle to disable STAT3 in ovarian cancer cells SKOV3.docx by Adina-Gabriela Vasilescu (22236073)

“…</p>Results<p>We demonstrate that anti-STAT3 mcDNA significantly reduces the viability of SKOV3 cells at low nanomolar concentrations, while sparing the control group. …”

Data Sheet 1_Comparative efficacy and safety of antidiabetic agents for post-transplant diabetes mellitus: a network meta-analysis.docx by Shanbiao Hu (15063765)

“…Background<p>Post-transplant diabetes mellitus (PTDM) significantly compromises patient and graft outcomes. …”

Chordoma preclinical models are insensitive to BAF complex inhibitor FHD-286, alone or in combination with gemcitabine by Chordoma Foundation (4391989)

“…Representative dose-response curves of the mean +/- the standard deviation are shown. The data was normalized to the DMSO-only control. …”

Figure 4 from Photoacoustic Tomography Detects Response and Resistance to Bevacizumab in Breast Cancer Mouse Models by Isabel Quiros-Gonzalez (14952835)

“…<b>A</b> and <b>B,</b> Oxygenation (SO₂^MSOT) and normalized hemoglobin content (THb) increase from enrollment (noted as “pre”) to endpoint of tumor excision (noted as “post”) in the Ctrl group (<b>A</b>), while in the Bev-NR group (<b>B</b>), SO₂^MSOT increases concurrently with a decrease in normalized THb. <b>C,</b> Conversely, the Bev-R group trend toward a significant decrease in SO₂^MSOT, with no significant change in normalized THb observed. …”

Expression changes of metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 in immunofluorescence (IF) staining. by Minyan Sun (19751378)

“…After treatment with QLQX or empagliflozin, the expression of MMP-9 significantly decreased. <b>C,</b> MFI of TIMP-1. IF staining showed that TIMP-1 expression was significantly decreased in the model group. …”

Data_Sheet_1_Effects of stand age and soil microbial communities on soil respiration throughout the growth cycle of poplar plantations in northeastern China.pdf by Xiangrong Liu (380124)

“…As stand age increased, Rs showed a significant decreasing trend. We further identified r-selected microbial communities (copiotrophic species) as key biological factors influencing the decline in Rs with increasing stand age. …”

Differences in lesion development of slow- and fast-growing meat-type chickens after experimental challenge with <i>Enterococcus cecorum</i> by Amanda Rosenbaum (19074302)

“…Additionally, circulating monocytes were increased and heterophil/lymphocyte (H/L) ratios were decreased in SG chickens compared to FG chickens. We may speculate that SG chickens were less affected by the EC-associated disease due to a more efficient innate immune response and may more vigorously control extra-intestinal colonization after translocation from the intestine. …”

Coupling of soil carbon and nitrogen during the anthropogenic transition from desert grassland to shrubland_Research Data by Yanan Zhao (16753416)

“…We also observed a shift from microbial mineralization to immobilization during the transition. …”

The Enzyme Effect: Broadening the Horizon of MS Optimization to Nontryptic Digestion in Proteomics by Kinga Nagy (603019)

“…We analyzed peptide scores for thousands of peptides and determined optimal collision energy (CE) values. …”

Image 1_One-year post lockdown trajectories of mental health and impact of COVID-19 lockdown-related factors.png by Mathilde Mongeau (20864315)

“…</p>Results<p>Our analysis revealed a significant decrease in the proportion of individuals experiencing poor mental health (elevated GAD-7 or PHQ-9 > 4) from lockdown period to 1 month and 6 months post-lockdown. …”