<b>Supporting data for ''The pathogenicity and pathogenic mechanism of SARS-CoV-2 Omicron''</b> by Bingjie Hu (10835565)

“…Further mechanistic investigations reveal that the Omicron subvariant is ineffective in using TMPRSS2 compared with ancestral SARS-CoV-2 (HKU-001a) and previous variants, which may contribute to its decreased replication in Calu3 and Caco2 cells. In K18-hACE2 transgenic mice, the replication capacity of the Omicron subvariant is significantly attenuated in both the upper and lower respiratory tracts of virus-infected animals when compared to that of the ancestral strain and Delta (B.1.617.2) variant, correlating with substantially ameliorated lung pathology. …”

Data Sheet 1_Splenic volume as a predictor of survival in cancer patients treated with immune checkpoint inhibitors.docx by Yunhua Zhang (231470)

“…Additionally, HCC patients who experienced an increase in spleen volume during ICI therapy exhibited significantly poorer OS (HR: 2.27, 95% CI: 1.17–4.41, p = 0.016) and PFS (HR: 2.40, 95% CI: 1.30–4.41, p = 0.005) than those whose spleen volume decreased. …”

Scenarios.csv by Anna Lipinska (20427389)

“…Using empirical data and simulated scenarios of snow cover disappearance, we assess the impacts of varying winter temperature minima on population survival and growth.…”

Table 1_Investigating the psychophysiological effects of NaiKan Therapy: salivary oxytocin and cortisol release.docx by Ming Qian (429232)

“…Conversely, salivary cortisol levels exhibited a decrease post-therapy, indicating a reduction in stress reactivity. …”

symulationvertigo.sce by Anna Lipinska (20427389)

“…Using empirical data and simulated scenarios of snow cover disappearance, we assess the impacts of varying winter temperature minima on population survival and growth.…”

Table 2_Investigating the psychophysiological effects of NaiKan Therapy: salivary oxytocin and cortisol release.xlsx by Ming Qian (429232)

“…Conversely, salivary cortisol levels exhibited a decrease post-therapy, indicating a reduction in stress reactivity. …”

Data Sheet 1_Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease.pdf by Faruk Hossen (20275670)

“…Specifically, we found significant decreases in insulin receptor-α (IR-α) and insulin receptor-β (IR-β) expression, along with increased levels of phospho-insulin receptor substrate 1 at Ser307 [p-IRS-1 (Ser307)] and decreased levels of p-IRS-1 (Tyr895), compared to wild-type (WT) mice. …”

Data Sheet 1_UV-LED disinfection of emerging Vibrio pathogens: inactivation kinetics and reactivation potential.pdf by Leonardo Romero-Martínez (22335241)

“…</p>Results and discussion<p>Results showed that V. parahaemolyticus was more UV-sensitive than V. alginolyticus, with inactivation rate constants of 1.22 and 1.60 cm²·mJ^-1 at 265 and 275 nm, respectively, compared to 0.82 and 0.69 cm²·mJ^-1 for V. alginolyticus. No significant differences were observed between the two wavelengths (265 nm and 275 nm) in terms of inactivation rate constants. …”

Data Sheet 1_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv by Huahua Li (6896339)

“…</p>Results<p>In patients with T2DM, a marked increase in monocytes and a decrease in CD4+ T cells were observed, indicating immune dysregulation. …”

Data Sheet 4_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv by Huahua Li (6896339)

“…</p>Results<p>In patients with T2DM, a marked increase in monocytes and a decrease in CD4+ T cells were observed, indicating immune dysregulation. …”

Data Sheet 2_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv by Huahua Li (6896339)

“…</p>Results<p>In patients with T2DM, a marked increase in monocytes and a decrease in CD4+ T cells were observed, indicating immune dysregulation. …”

Data Sheet 3_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv by Huahua Li (6896339)

“…</p>Results<p>In patients with T2DM, a marked increase in monocytes and a decrease in CD4+ T cells were observed, indicating immune dysregulation. …”

Data Sheet 1_Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells.pdf by Nadezhda Logunova (831700)

“…<p>Previously we have shown that H2-congenic recombinant mice of the B6.I-9.3 (H2-Ab1^j) strain are significantly more susceptible to tuberculosis (TB) infection compared to their C57BL/6 (B6, H2-A^b) ancestors. …”

Data Sheet 1_Refinement of the novel tank diving test: toward standardized and robust analysis of anxiety-like behavior in zebrafish.docx by Takuro Shinkai (22518659)

“…We optimized the detection parameters for region entry and freezing behavior using logistic regression analysis, significantly reducing false-positive classifications caused by tracking artifacts. …”

Data Sheet 1_Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.pdf by Dilara Yılmaz (19710658)

“…While these approaches have been applied to aging mice, their effectiveness in prematurely aging mouse models such as PolgA^D257A/D257A (PolgA) has not been completely explored. We demonstrated that frailty became evident in PolgA mice around 40 weeks, validated through body weight loss, reduced walking speed, decreased physical activity, and weaker grip strength. …”

Data Sheet 1_Dangua Fang induces anti-glucolipid metabolism disorder effects similar to those of direct NFIL3 inhibition.zip by Zhuang Han (471130)

“…The NFIL3 mRNA and protein expression levels in the serum, liver, and small intestine were significantly decreased. The relative abundance of Bacteroidota decreased, whereas that of Firmicutes increased, and changes in the gut microbiota significantly correlated with serum total cholesterol (TC), triglyceride (TG), and free fatty acid (FFA) levels. …”

Short-term antiretroviral therapy may not correct the dysregulations of plasma virome and cytokines induced by HIV-1 infection by Yingying Ma (3617810)

“…These results suggest that short-term ART may not significantly correct the virome and cytokine dysregulations induced by HIV-1 infection. …”

Supplementary file 2_Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a systematic review and meta-analysis.docx by Wang Wei (2074669)

“…Meta-analysis showed that acupuncture significantly improved the overall response rate, reduced the recurrence rate, decreased the urticaria activity score, and improved the Dermatology Life Quality Index, Hamilton Depression Scale, VAS itching score, and the Chronic Urticaria Quality of Life Questionnaire scores. …”

Supplementary file 4_Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a systematic review and meta-analysis.docx by Wang Wei (2074669)

“…Meta-analysis showed that acupuncture significantly improved the overall response rate, reduced the recurrence rate, decreased the urticaria activity score, and improved the Dermatology Life Quality Index, Hamilton Depression Scale, VAS itching score, and the Chronic Urticaria Quality of Life Questionnaire scores. …”

Supplementary file 5_Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a systematic review and meta-analysis.docx by Wang Wei (2074669)

“…Meta-analysis showed that acupuncture significantly improved the overall response rate, reduced the recurrence rate, decreased the urticaria activity score, and improved the Dermatology Life Quality Index, Hamilton Depression Scale, VAS itching score, and the Chronic Urticaria Quality of Life Questionnaire scores. …”