Data Sheet 1_Global burden of disease among adolescents and young adults with drug use disorders, 1990–2021: based on GBD 2021.doc by Ming Wang (172316)

“…</p>Conclusion<p>The disease burden of DUDs, measured by age-standardized DALY rates, varies across different SDI regions, with higher DALY rates observed in regions with high SDI. Additionally, gender plays a significant role in the distribution of this burden, with males experiencing a higher burden than females. …”

Table 1_LpxR and PagL expression in live attenuated auxotrophic Pseudomonas aeruginosa vaccines modulates lipid A reactogenicity in vitro while preserving immunogenicity.docx by Miriam Moscoso (345679)

“…Expression of LpxR led to enrichment in tetra-acylated species, while PagL expression reduced the heterogeneity observed in the wild type. Both mutant strains showed decreased TLR4 activation in vitro as compared to the wild type. …”

Data Sheet 1_Elevated Galectin-3 levels in the tumor microenvironment of ovarian cancer – implication of ROS mediated suppression of NK cell antitumor response via tumor-associated... by Veronika Karlsson (20457788)

“…In co-cultures with NK cells and K562 target cells, we observed that Galectin-3-induced production of reactive oxygen species in neutrophils resulted in decreased NK cell viability and lowered anti-tumor responses.…”

Data_Sheet_1_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV by Ming-Jie Jia (18267391)

“…</p>Results<p>The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. …”

Data_Sheet_2_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV by Ming-Jie Jia (18267391)

“…</p>Results<p>The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. …”

<b>Dataset of a </b><b>phase Ib clinical study: </b><b>rapid regression of high-risk carotid hemorrhagic </b><b>plaques with sonodynamic therapy</b> by Ye Tian (22423790)

“…The primary endpoint demonstrated a significant decrease in maximum wall thickness (MaxWT) at 1 month post-SDT in all plaques, particularly IPH plaques. …”

Table_1_Associations between metabolic score for visceral fat and adult lung functions from NHANES 2007–2012.docx by Jiacai Zhou (20325867)

“…However, no association was observed with peak expiratory flow rate (PEF). When dividing the METS-VF into thirds, participants in the highest third exhibited significantly decreased levels of FEV1 (β: −342, 95%CI: −440, −245, p < 0.001), FVC (β: −312, 95%CI: −431, −192, p < 0.001), FEV1/FVC (β: −0.020, 95%CI: −0.030, −0.010, p < 0.001), and FEF25-75% (β: −424, 95%CI: −562, −285, p < 0.001). …”

Figure 1 from Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal by Ángel Fernández-Sanromán (20814476)

“…Samples from patients K390, K243, and K153 are highlighted to illustrate the varied levels of transcriptional ITH in distinct patients. For patient K153, we highlight the phylogenetic tree branch containing the clones observed in the adjacent sample points. …”

Data_Sheet_1_Association of systemic immune-inflammation index with malnutrition among Chinese hospitalized patients: a nationwide, multicenter, cross-sectional study.docx by Mengyuan Chen (5633153)

“…Q₁, OR = 1.83, 95%CI: 1.67–2.00). However, a significant reduction in prevalence was observed when SII was in the second quartile (Q₂ vs. …”

Interactive effects of temperature and food ration on growth and mercury concentration in eastern brook trout by Ethan Rutledge (22284511)

“…We observed the lowest Hg concentrations in fish under the low temperature (15°C), high ration treatment, and the highest concentrations in the high temperature (22°C), zero ration treatment. …”

Data Sheet 1_CMOS-fabricated dielectrophoretic chip with embedded 3D TiN nano-electrode arrays for sperm capture and sperm damage reduction.docx by I-Hsuan Liao (19768716)

“…When operated under a 20 Vpp square wave, the chip only generated a temperature rise of 1.7°C, causing no significant damage to the sperms and no notable decrease in viability. …”

Table 1_Student wellbeing during COVID-19—Impact of individual characteristics, learning behavior, teaching quality, school system-related aspects and home learning environment.pdf... by Julian Brauchle (20788490)

“…Introduction<p>The measures taken to contain the COVID-19 pandemic had a significant impact on the lives of young people. Studies indicate a decrease in wellbeing and an increase in mental health problems among adolescents. …”

ORCA input files by yengtseng wang (19956387)

“…Huang et al. found that caffeine molecules can stabilise lipophilic drug/CD complexes, and caffeine-axitinib-hydroxypropyl-β-cyclodextrin (HPβCD) complexes can decrease the complex dissociation. To investigate the interaction mechanisms of the complexes, we employed a combination of computational methods, including molecular dynamics and density functional theory (DFT) calculations. …”

Flt3L-derived Antigen Presenting Cell transfer in neonatal NOD mice delays the incidence of Type 1 by Stephanie Orozco (7379687)

“…Our studies demonstrate that immature APCs travel to the pancreatic draining lymph nodes, alter the cytokine milieu in young mice, divert autoreactive CD4⁺ T cells to anergy and drastically decrease proliferation and function of CTLs in adult pre-diabetic mice leading to a significant reduction in the incidence of T1D.…”

Table 1_A national framework for transition to precision medicine.docx by Samaneh Karimi Esboei (20623664)

“…The results from the systematic review show that for the transition to PM, we must first move from common medicine to stratified medicine and then PM. …”

Video 2_CMOS-fabricated dielectrophoretic chip with embedded 3D TiN nano-electrode arrays for sperm capture and sperm damage reduction.mp4 by I-Hsuan Liao (19768716)

“…When operated under a 20 Vpp square wave, the chip only generated a temperature rise of 1.7°C, causing no significant damage to the sperms and no notable decrease in viability. …”

Video 1_CMOS-fabricated dielectrophoretic chip with embedded 3D TiN nano-electrode arrays for sperm capture and sperm damage reduction.mp4 by I-Hsuan Liao (19768716)

“…When operated under a 20 Vpp square wave, the chip only generated a temperature rise of 1.7°C, causing no significant damage to the sperms and no notable decrease in viability. …”

Down-Regulation of Annexin A Proteins in Human Mesangial Cells by TEGDMA and Bis-GMA Treatment Disrupts Proteins Involved in Cellular Function by Ayse Nur Dogan (21015836)

“…Transient knockdown of annexin A2 protein expression using annexin A2 siRNA resulted in a significant decrease in alpha smooth muscle actin and non-muscle myosin protein expression in human mesangial cells when compared to cells transfected with non-targeting control siRNA. …”

Data Sheet 1_Microbial and molecular signatures for enhanced gut health in pigs fed a diet with spray-dried plasma as functional protein source.docx by Soumya K. Kar (4600924)

“…We report a significant (P < 0.05) decrease in the relative abundance of the Sarcina genera in the small intestine, an effect comparable to pharmaceutical concentrations of zinc oxide (ZnO). …”

Supplementary Material for: A case report: Metastatic Gestational Trophoblastic Neoplasia leading to acute respiratory failure and death. About a particularly challenging managemen... by figshare admin karger (2628495)

“…In second-line, the patient was treated with carboplatin, with no significant response. In third-line, Pembrolizumab was used, and the patient experienced a significant decrease in HCG. …”