ExaF contributes to FA homeostasis by lowering the FA concentration. by Zachary T. Hying (21512605)

Data Sheet 1_Genetic variation in RYR1 is associated with heart failure progression and mortality in a diverse patient population.docx by Leonardo A. Guerra (20762270)

“…Based on eQTL data, these SNPs were associated with decreased RYR1 expression in vascular tissue. Two missense variants, in linkage disequilibrium with rs2915950 (rs2915952 and rs2071089) were significantly associated with decreased mortality risk (P = 0.03) and decreased risk of atrial fibrillation/flutter (OR: 0.66, 95% CI: 0.44–0.96; P = 0.03 and OR: 0.67, 95% CI: 0.45–0.98; P = 0.04, respectively). …”

Mechanism of hydrocephalus formation involving inflammation after IVH. by Tong Sun (1564231)

“…When NF-κB is inhibited after ventricular hemorrhage, a significant reduction in the size of the bilateral lateral ventricles is observed, along with a slowed CSF secretion rate and decreased expression of NF-κB and AQP1 proteins in CPEs. …”

AgTL2 embryos have altered lipids, metabolites, and transcriptional profiles during development. by Maurice A. Itoe (9930475)

“…(C) Heatmap of metabolites analyzed by LC-MS showing levels of the 60 most highly dysregulated metabolites in AgTL2 embryos compared to controls throughout development (values of <i>t</i> test statistic, range: blue to red = significant decrease to increase) (3 biological replicates represented by triplicate columns at each time point). …”

Effect of regional nerve block on tourniquet-related injury in pediatric patients undergoing lower limb surgery: a randomized controlled study by Qin Xia (1758646)

“…Additionally, patients in the PNB group had a significantly shorter time to first ambulation and a shorter hospital length of stay.…”

Metabolite concentrations and statistics for data displayed in Fig 8. by Zachary T. Hying (21512605)

Figure 5 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia by Sydney A. Skupa (18597728)

“…<p>Dysbiotic microbiome is observed in the aggressive syngeneic model of CLL. …”

This figure illustrates the impact of <i>Lactobacillus reuteri</i> supplementation on key indicators of colitis induced by dextran sulfate sodium (DSS). by Mohsen Nazari (6299819)

“…<b>(C)</b> Disease activity index (DAI) scores indicate a significant reduction in colitis severity in the <i>L. reuteri</i>-supplemented group. …”

Data Sheet 1_Physical activity of moderate-intensity optimizes myocardial citrate cycle in a murine model of heart failure.pdf by Lucyna Widacha (20981330)

“…</p>Results<p>Heart failure mice exhibited decreased exercise performance capacity as reflected by a lower total distance covered and time of running in wheels. …”

Data Sheet 1_Repeated biocide treatments cause changes to the microbiome of a food industry floor drain biofilm model.zip by Martin Laage Kragh (8341305)

“…<p>There is a concern about the development of microbial tolerance and resistance to biocides due to their repeated use within the food industry. …”

Application to actual brain network functional states. by Remy Ben Messaoud (20521877)

Data Sheet 1_TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury.zip by Yunsheng Zhang (474242)

“…Background<p>Traumatic brain injury (TBI) triggers a cascade of neuroinflammatory responses mediated by microglial activation, which significantly contributes to secondary brain damage. …”

Supplementary file 1_Evaluation of drug interactions in outpatients taking antipsychotic medications.docx by Bshra A. Alsfouk (13259895)

“…The most frequent potential adverse effects were increased sedation (36%), hyperglycemia (15%) and decreased blood pressure (14%). Receiving polypharmacy (i.e., ≥5 drugs concomitantly administered) was significantly associated with an increased probability of drug interaction occurrence (OR = 42, P = 0.0026). …”

Table 1_The efficacy and safety of danuglipron and orforglipron in patients with type 2 diabetes and obesity: a systematic review and meta-analysis.docx by Jingjing Zhou (179820)

“…Meta-analysis results demonstrated that danuglipron significantly decreased HbA1c (mean difference [MD]: −0.90; 95% CI: −1.06, −0.74), FPG (MD: −24.66; 95% CI: −30.45, −18.86) and weight (MD: −2.17; 95% CI: −3.10, −1.23) and improved FPI (MD: 2.94; 95% CI: 1.50, 4.38). …”

Supplementary file 1_Characteristics, clinical evidence and implementation effects of conditional approvals for drugs in China, a pooled analysis from 2020 to 2023.docx by Li Yang (6520)

“…<p>In late 2019, the conditional approval process for drugs in China transitioned from a pilot project to a formal program. Our study comprehensively analyzed 103 conditional approvals (CAs) authorized by the National Medical Products Administration (NMPA) from 2020 to 2023, specifically focusing on their characteristics, clinical evidence, and implementation effects. …”

Supplementary Material for: Spontaneous Massive Retroperitoneal Hematoma: A Rare Complication of Anticoagulation after Stenting in Malignant Superior Vena Cava Syndrome by figshare admin karger (2628495)

“…After the procedure, she was on prophylactic low-molecular-weight heparin and developed a large retroperitoneal hematoma with a significant decrease in haemoglobin on day four. …”

Prognostic value of cardiac troponin I in acute ischemic stroke patients treated with reperfusion therapy: a multicenter retrospective cohort study by Andrea Loggini (12077927)

“…Elevated cTnI was not significantly associated with sICH (OR:3.75, 95%CI 0.52–27.21, <i>p</i> = 0.19), but was independently associated with increased in-hospital mortality (OR:1.96, 95%CI 1.62–6.20, <i>p</i> = 0.025) and decreased odds of good functional outcome at 30 days (OR:0.40, 95%CI 0.19–0.84, <i>p</i> = 0.016). …”

Data Sheet 1_Endophytic and antagonistic Bacillus amyloliquefaciens 8SE-IF1-derived nanoparticles encumber phytopathogenic oomycetes, fungi, bacteria, and viruses with enhanced gro... by A. Mary Sharmila (21898730)

“…The water-diffusible extract (WDE) of Ba-8SE-IF1 significantly inhibited the mycelial growth of Pythium aphanidermatum (44.6%), Phytophthora nicotianae (60.1%), Fusarium oxysporum f. sp. lycopersici (65.5%), and Colletotrichum gloeosporioides (66.7%) in poisoned food assays; the growth of Ralstonia solanacearum and Xanthomonas campestris in the agar well method (inhibition zones of 20.25 mm and 28.52 mm, respectively); and decreased the symptoms produced by tomato spotted wilt virus (TSWV) in local lesion host (68.3%) and tomato leaf curl New Delhi virus (ToLCNDV) in tomato plants (66.1%). …”

Image 1_Clinical outcomes of an intelligent pressure-controlled disposable ureteroscope for Laser lithotripsy in renal stone surgery: a retrospective matched cohort study.tif by Zhong Lv (4568410)

“…The overall complication rate was significantly lower in the experimental group</p>Conclusions<p>The use of an intelligent pressure-controlled disposable ureteroscope with laser lithotripsy for upper urinary tract surgeries can effectively reduce postoperative inflammation indicators, decrease average hospital stay and renal pelvis pressure, and improve the initial and total stone clearance rates.…”

Image 2_Clinical outcomes of an intelligent pressure-controlled disposable ureteroscope for Laser lithotripsy in renal stone surgery: a retrospective matched cohort study.tif by Zhong Lv (4568410)

“…The overall complication rate was significantly lower in the experimental group</p>Conclusions<p>The use of an intelligent pressure-controlled disposable ureteroscope with laser lithotripsy for upper urinary tract surgeries can effectively reduce postoperative inflammation indicators, decrease average hospital stay and renal pelvis pressure, and improve the initial and total stone clearance rates.…”