Adverse event list. حسب Stefan Halbherr (21353882)

"…No statistically significant improvements were seen in the Montreal Cognitive Assessment (MoCA) (mean decrease −0.73; 95% CI; −2.1, 0.62; <i>p</i> = 0.255), Epworth Sleepiness Scale (mean increase 0.09; 95% CI; −2.6, 2.8; <i>p</i> > 0.999), Beck Depression Inventory (BDI) (mean decrease −1.27; 95% CI; −3.8, 1.3; <i>p</i> = 0.257), and the Starkstein Apathy Scale (mean increase 0.36; 95% CI; −1.6, 2.4; <i>p</i> = 0.822). …"

Patient characteristics. حسب Stefan Halbherr (21353882)

"…No statistically significant improvements were seen in the Montreal Cognitive Assessment (MoCA) (mean decrease −0.73; 95% CI; −2.1, 0.62; <i>p</i> = 0.255), Epworth Sleepiness Scale (mean increase 0.09; 95% CI; −2.6, 2.8; <i>p</i> > 0.999), Beck Depression Inventory (BDI) (mean decrease −1.27; 95% CI; −3.8, 1.3; <i>p</i> = 0.257), and the Starkstein Apathy Scale (mean increase 0.36; 95% CI; −1.6, 2.4; <i>p</i> = 0.822). …"

Data Sheet 1_Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study).docx حسب Alexia Giovanazzi (16816139)

"…At 12 months, the median change in HbA1c levels did not differ significantly between groups. …"

Data Sheet 2_Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study).docx حسب Alexia Giovanazzi (16816139)

"…At 12 months, the median change in HbA1c levels did not differ significantly between groups. …"

Data Sheet 1_A comparative analysis of nutritional content changes in six Chinese cuisines prepared using industrial versus traditional hand-cooked modes.docx حسب Xuan Wang (55634)

"…In contrast, water-soluble vitamins, specifically B1, B2, B3, and B6, experienced substantial decreases across all examined dishes. The fatty acid profiles were consistent with the fat content, and mineral content demonstrated a moderate increase under both cooking conditions. …"

Presentation 1_Prevalence trend and burden of foodborne trematodiasis in China from 1990 to 2021 and its predictions until 2030: a comparative study with Japan and South Korea.pdf حسب Runzhou Ma (19758996)

"…</p>Conclusion<p>The study reveals contrasting trends in FBT burden among the three East Asian countries, with significant declines in China, a slight decrease in South Korea despite higher-than-global rates, and an increasing but low burden in Japan. …"

Table 1_Diverging trends in the global burden of ischemic heart disease attributable to non-optimal temperatures: a historical analysis (1990–2021) and 2050 projections.docx حسب Zehao Jin (11408687)

"…Significant socioeconomic disparities were observed, with low-to-middle SDI regions bearing a disproportionate share (75.0%) of the global high non-optimal temperature-related mortality burden. …"

Data Sheet 1_Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target.csv حسب Jie Zheng (31208)

"…In vivo, Gyg1 was markedly upregulated in septic mice, and LNP-mediated siRNA knockdown of Gyg1 significantly improved survival in the LPS model. Mechanistically, Gyg1 knockdown significantly reduced glycogen content in myeloid cells, attenuated IL-6 and TNF-α production, alleviated LPS-induced neutrophil, and modestly decreased CD40 expression in monocytes and dendritic cells. …"

Data Sheet 1_Thymoquinone/β-N-acetylglucosaminidase, a novel plant-derived combination, inhibited quorum sensing signaling pathways and disrupted biofilm in Staphylococcus aureus.p... حسب Adel Attia M. Ahmad (16729177)

"…Notably, NAGase, whether used alone or in conjunction with TQ, led to a decrease in the expression of the atl, icaA, and agr genes.…"

Table1_Asparagus officinalis L. extract exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells and a transgenic mouse model of endometrial cancer.pdf حسب Ziwei Fang (10115899)

"…Asparagus officinalis extract treatment for 4 weeks resulted in a significant reduction in tumor growth in Lkb1^fl/flp53^fl/fl mice under both obese and lean conditions, with a decrease in Ki-67 and vascular endothelial growth factor expression and an increase in Bip expression in endometrial tumors.…"

Table2_Asparagus officinalis L. extract exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells and a transgenic mouse model of endometrial cancer.pdf حسب Ziwei Fang (10115899)

"…Asparagus officinalis extract treatment for 4 weeks resulted in a significant reduction in tumor growth in Lkb1^fl/flp53^fl/fl mice under both obese and lean conditions, with a decrease in Ki-67 and vascular endothelial growth factor expression and an increase in Bip expression in endometrial tumors.…"

Data Sheet 1_Impact of fatigue in Crohn's disease is negatively related to resting state functional connectivity between the superior parietal lobule and parahippocampal gyrus/hipp... حسب Theresa A. McIver (21178337)

"…Moderation analyses revealed a significant interaction between disease activity, total fatigue, and functional connectivity of the right superior parietal lobule and left anterior parahippocampal gyrus (ΔR² = 0.058, F = 5.445, p = 0.0245). …"

Table 1_A peptide mimic of SOCS1 modulates equine peripheral immune cells in vitro and ocular effector functions in vivo: implications for recurrent uveitis.docx حسب Lauren Stewart Stafford (17937497)

"…</p>Results<p>Following SOCS1-KIR pretreatment, cell proliferation significantly decreased in control, but not ERU-derived PBMCs. …"

Table 1_Genetic diversity and antibiotic resistance of Mycobacterium bovis in bovines in the Delta area of Egypt.docx حسب Mohamed Sabry A. Elsayed (22235200)

"…Introduction<p>Mycobacterium bovis (M. bovis) causes significant financial harm to the cattle industry through decreased productivity and trade limitations, while also posing a risk to human health through zoonotic transmission, which is primarily from unpasteurized milk or close animal contact.…"

Data Sheet 1_A comparative study on tobacco prevalence and secondhand smoke exposure before and after the lockdown in Rizhao, China: analysis of 2022 and 2024 data.pdf حسب Zhao-Hui Liang (21604178)

"…The chi-square test was used to determine whether there were significant differences.</p>Result<p>A total of 1872 valid questionnaires were collected from the two surveys. …"

Supplementary file 1_IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.d... حسب Zekuan Xue (21398444)

"…<p>Mesenchymal stem cells (MSCs) can participate in lymphangiogenesis through paracrine effects, while lymphatic endothelial progenitor cells (LEPCs), a subpopulation of endothelial progenitor cells (EPCs), can differentiate into mature lymphatic endothelial cells, thereby influencing lymphatic function. …"

Data Sheet 1_Protein-free domains in native and ferroptosis-driven oxidized cell membranes: a molecular dynamics study of biophysical properties and doxorubicin uptake.pdf حسب Yaser Shabanpour (13247160)

"…<p>Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation of polyunsaturated fatty acids (PUFAs). …"

Major hyperparameters of RF-SVR. حسب Jintao Li (448681)

"…For instance, the RF-MLPR model achieved a 3.7%–6.5% improvement in the Nash-Sutcliffe efficiency (NSE) metric across four hydrological stations compared to the RF-SVR model. (4) Prediction accuracy decreased with longer forecast periods, with the R² value dropping from 0.8886 for a 1-month forecast to 0.6358 for a 12-month forecast, indicating the increasing challenge of long-term predictions due to greater uncertainty and the accumulation of influencing factors over time. (5) The RF-MLPR model outperformed the RF-SVR model, demonstrating a superior ability to capture the complex, nonlinear relationships inherent in the data. …"

Pseudo code for coupling model execution process. حسب Jintao Li (448681)

"…For instance, the RF-MLPR model achieved a 3.7%–6.5% improvement in the Nash-Sutcliffe efficiency (NSE) metric across four hydrological stations compared to the RF-SVR model. (4) Prediction accuracy decreased with longer forecast periods, with the R² value dropping from 0.8886 for a 1-month forecast to 0.6358 for a 12-month forecast, indicating the increasing challenge of long-term predictions due to greater uncertainty and the accumulation of influencing factors over time. (5) The RF-MLPR model outperformed the RF-SVR model, demonstrating a superior ability to capture the complex, nonlinear relationships inherent in the data. …"

Major hyperparameters of RF-MLPR. حسب Jintao Li (448681)

"…For instance, the RF-MLPR model achieved a 3.7%–6.5% improvement in the Nash-Sutcliffe efficiency (NSE) metric across four hydrological stations compared to the RF-SVR model. (4) Prediction accuracy decreased with longer forecast periods, with the R² value dropping from 0.8886 for a 1-month forecast to 0.6358 for a 12-month forecast, indicating the increasing challenge of long-term predictions due to greater uncertainty and the accumulation of influencing factors over time. (5) The RF-MLPR model outperformed the RF-SVR model, demonstrating a superior ability to capture the complex, nonlinear relationships inherent in the data. …"