Data Sheet 5_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.pdf by Paolo Romania (399007)

“…PLAC1 and DSG2 expression in healthy tissues and NK cells was obtained from the HPA database and a GEO dataset.</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …”

Sox2 is upstream of <i>Atoh1</i> and <i>Huwe1</i> in embryonic development and <i>Huwe1</i> knockdown results in hair cell generation from dividing supporting cells. by Yen-Fu Cheng (5819855)

Certainty of affect predicted by valence and low, medium, and high trait emotional intelligence Predicted certainty of knowing how you feel in a trial, as predicted by the subject’... by Anthony G. Vaccaro (5964368)

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Data Sheet 1_Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized control... by Sumaiah J. Alarfaj (12889115)

“…</p>Results<p>Compared to the placebo group (n = 24), the atorvastatin group (n = 23) exhibited a significant decrease in the level of IL-6 (p = 0.001), S1P (p = 0.0001), TNF-α (p = 0.003), NO (p = 0.0001), CRP (p = 0.015), ESR (p = 0.012), PMS (p = 0.013), and fecal calprotectin (p = 0.0003), and improved SF-36 (p = 0.006). …”

Evolutionary relationships between tooth size and jaw protrusion. by Nick Peoples (21593888)

Effects of injury on exploratory behavior. by Ella R. Dockendorf (21533334)

Impact of p53 T253I on expression of DNA damage responsive proteins. by Nathaniel C. Holcomb (22793595)

Mutant p53 proteins have impaired DNA binding and transcriptional regulation. by Nathaniel C. Holcomb (22793595)

Impact of p53 T253I on DNA damage responsive mRNA expression. by Nathaniel C. Holcomb (22793595)

Stable incorporation of p53 lentiplasmids is detectible and does not impact cellular growth rates. by Nathaniel C. Holcomb (22793595)

Livestock–Crop–Mushroom (LCM) Circular System: An Eco-Friendly Approach for Enhancing Plant Performance and Mitigating Microbiological Risks by Dong Liu (115204)

“…Mushroom production using agroforestry biowaste is a great green cycling agriculture alternative. …”

Retention and extinction of operant learning. by Ella R. Dockendorf (21533334)

ITPL-1 also reduces female receptivity but does not affect ovipostion in the brown planthopper. by Yi-Jie Zhang (713506)

Data Sheet 1_A randomized study on the effect of a wearable device using 0.75 Hz transcranial electrical stimulation on sleep onset insomnia.docx by Stephen B. Simons (19931955)

“…Introduction<p>The normal transition to sleep is characterized by a reduction in higher frequency activity and an increase in lower frequency activity in frontal brain regions. …”

Subcellular fractionation of HEK293 p53 wt and mutant proteins. by Nathaniel C. Holcomb (22793595)

¹⁷⁷Lu-Labeled Heterodimeric Agent with High Stability Targeting Neovascularization for Tumor Radioligand Therapy by Biao Yang (545048)

“…Radiopharmaceutical theranostics holds significant promise in tumor diagnosis and treatment, but suboptimal tumor uptake and retention remain a persistent limitation. …”

Supplementary file 1_Effects of a personalized PERMA-based intervention on the mental health of junior high school students: a randomized clinical trial.docx by Lei Zhang (38117)

“…No significant changes were observed in coping styles, though slight improvements in positive coping tendency (from −0.02 to −0.13) and a slight decrease in negative coping tendency (from −0.02 to −0.01).…”