Addressing Imbalanced Classification Problems in Drug Discovery and Development Using Random Forest, Support Vector Machine, AutoGluon-Tabular, and H2O AutoML حسب Ayush Garg (21090944)

"…The important findings of our studies are as follows: (i) there is no effect of threshold optimization on ranking metrics such as AUC and AUPR, but AUC and AUPR get affected by class-weighting and SMOTTomek; (ii) for ML methods RF and SVM, significant percentage improvement up to 375, 33.33, and 450 over all the data sets can be achieved, respectively, for F1 score, MCC, and balanced accuracy, which are suitable for performance evaluation of imbalanced data sets; (iii) for AutoML libraries AutoGluon-Tabular and H2O AutoML, significant percentage improvement up to 383.33, 37.25, and 533.33 over all the data sets can be achieved, respectively, for F1 score, MCC, and balanced accuracy; (iv) the general pattern of percentage improvement in balanced accuracy is that the percentage improvement increases when the class ratio is systematically decreased from 0.5 to 0.1; in the case of F1 score and MCC, maximum improvement is achieved at the class ratio of 0.3; (v) for both ML and AutoML with balancing, it is observed that any individual class-balancing technique does not outperform all other methods on a significantly higher number of data sets based on F1 score; (vi) the three external balancing techniques combined outperformed the internal balancing methods of the ML and AutoML; (vii) AutoML tools perform as good as the ML models and in some cases perform even better for handling imbalanced classification when applied with imbalance handling techniques. …"

Table 1_The impact of diagnosis-related group-based medical insurance payment model on the prognosis and nursing care of patients undergoing composite trabeculectomy: a retrospecti... حسب Yu Wang (12152)

"…Furthermore, the reform was associated with a marked decrease in hospitalization expenses and nursing costs. …"

Visual motor response assay at 28 dpf. حسب Morgan Barnes (7876373)

"…(E-H) VMR parameters in dnVDRa induced zebrafish at 48 hpf. There is a significant decrease in distance moved in the dark period (p < 0.05), a significant decrease in velocity in the dark (p < 0.05) and light (p < 0.01) periods, a significant decrease in activity state in the dark period (p < 0.001) and light period (p < 0.01) and a significant decrease in distance to point in the dark period (p < 0.05) and light period (p < 0.05) in the 48 + fish. …"

Development of hamstring strength throughout the LIST. حسب Dominic Michael Rasp (19959412)

Development of the limb symmetry index (LSI) over the course of the LIST. حسب Dominic Michael Rasp (19959412)

Data Sheet 1_Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma.zip حسب Qiwei Zhao (12519351)

"…Moreover, CAP inhibited glutamate release while enhancing BECN1-SLC7A11 binding, suggesting a reduction in SLC7A11 activity through the AMPK/BECN1 pathway. …"

Gene expression of neurotransmitter pathways at 6 dp. حسب Morgan Barnes (7876373)

"…In the 24 hpf dnVDRa induced group we see a significant decrease in glyt1 expression (p < 0.05) and an increase in glyt2 expression (p < 0.05) and in slc32a1 expression (p < 0.01). …"

Trends of uptake of delivery by CS and trends of the uptake of maternity incentives among women who had at least a live birth and gave birth in HFs one year prior to the three most... حسب Resham B. Khatri (10949429)

Table 1_To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux.docx حسب Chenglin Jia (578595)

"…</p>Results<p>Ruanjian Qingmai granules significantly decreased lipid deposition and significantly increased the expression of CYP7A1 mRNA in both zebrafish and HepaRG cells. …"

Data Sheet 5_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.csv حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Data Sheet 2_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.csv حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Image 4_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.tif حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Image 3_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.tif حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Data Sheet 1_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.csv حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Image 1_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.tif حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Image 2_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.tif حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Data Sheet 4_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.csv حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Data Sheet 3_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.csv حسب Ben Wang (250897)

"…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…"

Image 1_Iodine-131 induces ferroptosis and synergizes with sulfasalazine in differentiated thyroid cancer cells via suppressing SLC7A11.tif حسب Li Ling (424480)

"…Moreover, the combination of SAS and ¹³¹I significantly increased the MDA levels and lipid peroxidation, decreased the GSH levels, and suppressed the expression of SLC7A11 and GPX4, while SLC7A11 knockdown significantly enhanced ferroptosis-related markers in DTC cells. …"

DataSheet1_Changes in serum uteroglobin level in type 2 diabetes mellitus patients.docx حسب Joung Youl Lim (18237598)

"…</p>Conclusions<p>Uteroglobin is a sensitive factor that was decreased even in prediabetes and increased upon treatment with drugs with anti-inflammatory effects. …"