Table 3_Comparison between the protective effect of the orally administered atorvastatin and safflower (Carthamus tinctorius) in hypercholesterolemic male rats.docx by Haddad A. El Rabey (22248019)

“…The induced hypercholesterolemia significantly raised liver function enzymes, lipid peroxidation (14.9 ± 0.11 mg/dL), total cholesterol (273.3 ± 1.1 mg/dL), triglycerides (223.0 ± 4.1 mg/dL), low-density lipoproteins (204.7 ± 0.9 mg/dL), very low-density lipoproteins (44.6 ± 0.8 mg/dL), troponin, creatine kinase (CK), and adrenaline while decreased antioxidant enzymes, high-density lipoprotein (HDL), and vitamin D (11.1 ± 0.5 ng/mL). …”

Table 2_Comparison between the protective effect of the orally administered atorvastatin and safflower (Carthamus tinctorius) in hypercholesterolemic male rats.docx by Haddad A. El Rabey (22248019)

“…The induced hypercholesterolemia significantly raised liver function enzymes, lipid peroxidation (14.9 ± 0.11 mg/dL), total cholesterol (273.3 ± 1.1 mg/dL), triglycerides (223.0 ± 4.1 mg/dL), low-density lipoproteins (204.7 ± 0.9 mg/dL), very low-density lipoproteins (44.6 ± 0.8 mg/dL), troponin, creatine kinase (CK), and adrenaline while decreased antioxidant enzymes, high-density lipoprotein (HDL), and vitamin D (11.1 ± 0.5 ng/mL). …”

Data_Sheet_1_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV by Ming-Jie Jia (18267391)

“…</p>Results<p>The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. …”

Data_Sheet_2_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV by Ming-Jie Jia (18267391)

“…</p>Results<p>The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. …”

Table 1_A comparative study on tobacco prevalence and secondhand smoke exposure before and after the lockdown in Rizhao, China: analysis of 2022 and 2024 data.docx by Zhao-Hui Liang (21604178)

“…The chi-square test was used to determine whether there were significant differences.</p>Result<p>A total of 1872 valid questionnaires were collected from the two surveys. …”

Efficacy and safety of trastuzumab deruxtecan in HER2-high and HER2-low breast cancer: a systematic review and meta-analysis of randomized controlled trials by Sheng-Yen Hsiao (9939006)

“…This meta-analysis assessed four randomized controlled trials (DESTINY-Breast02, −03, −04, and −06; 2555 patients) from PubMed, Embase, Cochrane Library, and ClinicalTrials.gov. A random-effects model revealed that T-DXd significantly improved progression-free survival (hazard ratio [HR] = 0.433; 95% confidence interval [CI]: 0.305–0.616; P < 0.001; <i>I²</i> = 90.7%) and overall survival (HR = 0.720; 95% CI: 0.636–0.816; P < 0.001; <i>I²</i> = 0%) versus control regimens, with consistent benefits across HER2 subgroups. …”

Overview of lipid detection by widely targeted lipidomics. by Min Feng (141118)

Table 1_Evaluating the impact of an integrated KIPP and positive psychology course on university students’ psychological well-being in China: a mixed-methods study.pdf by Tzu-Hsuan Liu (12978194)

“…</p>Results<p>Quantitative results showed significant increases in happiness and decreases in depression and anxiety, which highlighted the additive and substitutive roles of strengths-based practices. …”

Data_Sheet_1_Efficacy and safety of Latilactobacillus curvatus LB-P9 on hair health: a randomized, double-blind, placebo-controlled clinical trial.docx by Sun Young Choi (793010)

“…The subjective indicator of participant satisfaction, which improves as survey scores decrease, significantly decreased in the test group by −17.81 ± 14.35 points (p < 0.001) after 24 weeks of consuming the test food than before consuming it. …”

Supplementary file 1_The efficacy and safety of Fuzheng traditional Chinese medicine injections in the treatment of acute ischemic stroke: a systematic review and network meta-anal... by Qiaosheng Ren (20532449)

“…The overarching hypothesis was that although TCMIs + CT as a class provides benefit over CT alone, their therapeutic profiles differ.…”

Data Sheet 1_Case Report: Metabolic alterations and cholesterol esterification in a low-grade diffuse astrocytoma patient who progressed to glioblastoma at recurrence.docx by Omkar B. Ijare (22274167)

“…Particularly, IDH wildtype (IDHwt) diffuse astrocytomas harboring TERT promoter (TERTp) mutations, classified as molecular GBM under the 2021 WHO classification, may exhibit distinct metabolic and epigenetic features compared to histological WHO Grade 4 GBMs. Here, we conducted a detailed metabolomic comparison of tumor specimens from a patient initially diagnosed with WHO Grade 2 IDHwt diffuse astrocytoma carrying TERTp mutation, who subsequently progressed to a histologically confirmed WHO Grade 4 GBM upon recurrence.…”

Data Sheet 1_Dietary seaweed extract mitigates oxidative stress in Nile tilapia by modulating inflammatory response and gut microbiota.docx by Muhammad A. B. Siddik (6569957)

“…Fish fed the GE diet also showed a significantly lower lipid peroxidation by decreased malondialdehyde level when compared to control (p < 0.05). …”

Sketches of the two circuits used. by Lars-Olav Harnisch (22008639)

“…In the design of circuit-2, MP exceeded the 12 J/min threshold in both lung simulators at elevated RR and could only be decreased through valve closure followed by a consequential hypoventilation in one simulator.…”

Table 1_Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson’s disease: a multisite functional magnetic resonance imaging study.doc... by Bin Qin (544949)

“…Introduction<p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder imposing a significant global burden, characterized by motor dysfunction linked to aberrant basal ganglia activity. …”

Image 1_Modulation of VR-HMD-induced cybersickness using cathodal transcranial direct current stimulation: a functional near-infrared spectroscopy study.jpeg by Seong Ho Yun (22686965)

“…Results showed that cathodal tDCS significantly reduced nausea-related cybersickness symptoms compared to sham stimulation (p < 0.05). fNIRS analysis revealed decreased oxyhemoglobin concentrations in the bilateral superior parietal lobule and angular gyrus following cathodal tDCS, indicating reduced cortical activity in these regions. …”

Image 2_Modulation of VR-HMD-induced cybersickness using cathodal transcranial direct current stimulation: a functional near-infrared spectroscopy study.jpeg by Seong Ho Yun (22686965)

“…Results showed that cathodal tDCS significantly reduced nausea-related cybersickness symptoms compared to sham stimulation (p < 0.05). fNIRS analysis revealed decreased oxyhemoglobin concentrations in the bilateral superior parietal lobule and angular gyrus following cathodal tDCS, indicating reduced cortical activity in these regions. …”

Data Sheet 2_Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.pdf by Samira Rastgoo (15252703)

“…Background<p>Immunosenescence is an important factor in the impaired immune response in older adults and plays a significant role in the development of biological aging. …”

Data Sheet 1_Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.pdf by Samira Rastgoo (15252703)

“…Background<p>Immunosenescence is an important factor in the impaired immune response in older adults and plays a significant role in the development of biological aging. …”

<b>Dataset of a </b><b>phase Ib clinical study: </b><b>rapid regression of high-risk carotid hemorrhagic </b><b>plaques with sonodynamic therapy</b> by Ye Tian (22423790)

“…The primary endpoint demonstrated a significant decrease in maximum wall thickness (MaxWT) at 1 month post-SDT in all plaques, particularly IPH plaques. …”

Table 1_Inverse association between atherogenic index of plasma and testosterone in US adult males: A large cross-sectional study from the NAHNES 2011–2016.xlsx by Tanjian Li (20431610)

“…Serum lipids have been proven to influence serum testosterone levels, and AIP is a significant marker of lipid levels. We hypothesize that AIP may have a specific relationship with testosterone. …”