Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms حسب Farman M. Abbasi (22318766)

"…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms حسب Farman M. Abbasi (22318766)

"…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"

Changes in bioimpedance by sex. حسب Domingos L. S. Rios (20496173)

"…Methods: This study was a retrospective cohort comparing exposure variables in a secondary data analysis with a pre-post treatment design. …"

Clinical and epidemiological characteristics. حسب Domingos L. S. Rios (20496173)

"…Methods: This study was a retrospective cohort comparing exposure variables in a secondary data analysis with a pre-post treatment design. …"

Changes in bioimpedance by age. حسب Domingos L. S. Rios (20496173)

"…Methods: This study was a retrospective cohort comparing exposure variables in a secondary data analysis with a pre-post treatment design. …"

S1 Data - حسب Domingos L. S. Rios (20496173)

"…Methods: This study was a retrospective cohort comparing exposure variables in a secondary data analysis with a pre-post treatment design. …"

Location of weather stations used in the study. حسب Maksim Khitrykau (20107936)

"…Heat waves are characterized by a decrease in the average duration by 1 day and the smallest temperature changes, because due to increase in average values, summer temperatures got closer to thresholds for a heat wave. …"

Role of MIB2 in tumor cell growth <i>in vitro.</i> حسب Rui Li (4631)

Role of MIB2 and CAMK2 in FAT1-depndent regulation of YAP/TAZ protein levels and YAP/TAZ nuclear localization. حسب Rui Li (4631)

Regulation of YAP/TAZ through MIB2 in HNSCCs. حسب Rui Li (4631)

Cytochrome bd-II oxidase CyxA promotes the pathogenicity of <i>Klebsiella pneumoniae</i> by resisting oxidative stress حسب Xiao Xiao (99147)

"…Additionally, the expression levels of <i>cyxA</i> at 37°C and 41°C were significantly higher compared to 30°C, and the Δ<i>cyxA</i> strain exhibited significantly lower viable counts, elevated intracellular reactive oxygen species (ROS) levels, and decreased total antioxidant capacity (T-AOC) relative to WT at 37°C and 41°C. …"

Graphs showing the qPCR data from SD, ED, HFD and SDG larvae at 7 dpf (n = 6 for each). حسب Jessica C. M. Hui (20370522)

Box plots to show various parameters of GI motility in the anterior, mid, and posterior intestine of ED, HFD and SDG larvae compared with the SD controls, at 7 dpf. حسب Jessica C. M. Hui (20370522)

Box plots to show various parameters of GI motility in the anterior, mid, and posterior intestine of ED, HFD and SDG larvae compared with the SD controls, at 7 dpf. حسب Jessica C. M. Hui (20370522)

Box plots to show various parameters of the rectal waves ED, HFD and SDG larvae compared with the SD controls, at 7 dpf. حسب Jessica C. M. Hui (20370522)

Composition of experimental diets fed to cherry shrimp (<i>N</i>. <i>davidi</i> var. red) including varying concentrations of astaxanthin and <i>Bidens pilosa</i> extract over a 8-... حسب Wei-Wei Hou (3405947)

Superimposed structures of AKT2 native (green color) and mutant (red color) models to visualize the stereochemical conformation of wild type and mutant residues at (a) 274, (b) 265... حسب Sadia Afrin Runa (22504971)

Measurements of body mass index (BMI) and adipose deposits. حسب Jessica C. M. Hui (20370522)

Role of YAP/TAZ in FAT1-regulated HNSCC growth. حسب Rui Li (4631)

Loss of FAT1 expression results in increased YAP/TAZ protein levels. حسب Rui Li (4631)