Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Column charts of SI_8min and SI_10min in the therapy and control group at follow-up. by Felix L. Herr (21544362)

Sodium levels (mg/100 g) in matched restaurant menu items in 2016 and 2020 by UK NSRI food categories with ≥ 10 items. by Caroline G. Middleton (22041479)

(a) Change rates were calculated for each transect along the coastlines from 1985 to 2023; (b) Coastline change rates of the Caspian Sea based on the EPR and LRR. by Zihao Duan (17403792)

A comparison of <i>E. coli</i> contamination at Traditional Lanna restaurants before and after the model’s implementation. by Vivat Keawdounglek (9710710)

Log2 fold change (FC), mean and standard deviation (SD) of each lipid specie from the normal liver (NL) and metabolic dysfunction-associated steatohepatitis (MASH) groups, and adju... by Laia Bertran (3685147)

Log2 fold change (FC), mean and standard deviation (SD) of each lipid specie from the simple steatosis (SS) and metabolic dysfunction-associated steatohepatitis (MASH) groups, and... by Laia Bertran (3685147)

A schematic representation of how BM-MSCs reduce inflammation, oxidative stress, and cell death to alleviate decompression induced acute lung injury. by Chen Lu (135200)

Centrifuged FMT products consistently exhibit the lowest median log₁₀ drop of CFU/g following freezing and lyophilization. In contrast, unprocessed feces exhibited the greatest median log₁₀ drop and had a statistically significant loss of bacterial viability across both storage conditions. Products with M:D were the only cryopreserved products to exhibit a significant decrease in surrogate bacterial viability after freezing.... by Nina K. Randolph (21030732)

“…Products with M:D were the only cryopreserved products to exhibit a significant decrease in surrogate bacterial viability after freezing. …”

Three-dimensional visualization of the binary image, illustrating the spatial distribution and morphology of two distinct phases within a cubic volume. The black regions represent... by Mouad Klai (20818364)

Rate of missing trials. by Tomoe Hayakawa (20978784)

Morphological Degradation of Oxygen Evolution Reaction-Electrocatalyzing Nickel Selenides at Industrially Relevant Current Densities by Felix Hiege (21700895)

“…The transformation of the precatalyst goes along with a significant improvement in the charge transfer kinetics observed by decreasing Tafel slopes with ongoing experimental time extracted from cyclic voltammetry (CV) experiments and electrochemical impedance spectroscopy (EIS) in the high-frequency range. …”

Morphological Degradation of Oxygen Evolution Reaction-Electrocatalyzing Nickel Selenides at Industrially Relevant Current Densities by Felix Hiege (21700895)

“…The transformation of the precatalyst goes along with a significant improvement in the charge transfer kinetics observed by decreasing Tafel slopes with ongoing experimental time extracted from cyclic voltammetry (CV) experiments and electrochemical impedance spectroscopy (EIS) in the high-frequency range. …”

Morphological Degradation of Oxygen Evolution Reaction-Electrocatalyzing Nickel Selenides at Industrially Relevant Current Densities by Felix Hiege (21700895)

“…The transformation of the precatalyst goes along with a significant improvement in the charge transfer kinetics observed by decreasing Tafel slopes with ongoing experimental time extracted from cyclic voltammetry (CV) experiments and electrochemical impedance spectroscopy (EIS) in the high-frequency range. …”

Supplemental data 3. by Zachary J. Hough (20840430)

“…We have connected Akt3 to Aurora B, a significant player in chromosome segregation. …”

ROI selection. by Felix L. Herr (21544362)

Representative immunohistochemical stainings. by Felix L. Herr (21544362)

The Throttle Effect in Metal–Organic Frameworks for Distinguishing Water Isotopes by Xiao Xiao (99147)

“…By monitoring fluorescence intensity changes in Ura, the transport diffusion process could be quantified to reveal the diffusion constant of solvents. When we pushed the Ura occupancy to its limit (from 59% to 76% and 98%), the diffusion rate decreases by 2 orders of magnitude. …”