Utilization of lactate trajectory models for predicting acute kidney injury and mortality in patients with hyperlactatemia: insights across three independent cohorts حسب Yipeng Fang (14132676)

"…When compared with the Traj-3, Traj-2 was only significantly associated with the decreased risk of hospital mortality (OR 0.17, 95% CI 0.14–0.20, <i>p</i> < 0.001), but no with the likelihood of AKI development (OR 0.90, 95% CI 0.77–1.05, <i>p</i> = 0.172). …"

Supplementary file 1_Clinical characteristics and mortality risk factors among hospitalized infants and children with pertussis in China: a retrospective study.docx حسب Shuhan Zheng (18614305)

"…</p>Methods<p>We retrospectively evaluated the clinical data of 197 hospitalized children with pertussis admitted to Children’s Hospital, Zhejiang University School of Medicine, from 2019 to 2024. …"

Image 2_Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors.tif حسب Yiping Cao (1229856)

"…Pharmacological activation of local PVT A_2AR with its agonist CGS21680 induced significantly decreased 50% paw withdrawal threshold (50%PWTs) and paw withdrawal latency (PWLs), as measured by the Von Frey test and Hargreaves test in adult mice. …"

Data Sheet 3_Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke.zip حسب Fengli Ye (22123540)

"…Machine learning identified four hub genes—LEF1, ITGAX, BLVRB, and ATF4. All were significantly upregulated in ICH tissues and plasma, correlating with immune cell infiltration. …"

Data Sheet 1_Spleen tyrosine kinase inhibition mitigates radiation-induced lung injury through anti-inflammatory effects and downregulation of p38 MAPK and p53.pdf حسب Guoxing Zhang (4994213)

"…Lungs were harvested for further analysis 14 days and 10 weeks post-irradiation.</p>Results<p>We screened Syk as one of the most important driver genes of radiation pneumonitis by bioinformatics analysis and screened the preferred Syk inhibitor fostamatinib from the drug database. …"

Data Sheet 1_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.csv حسب Ying Dong (41989)

"…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …"

Image 2_Cellular immune responses of bovine polymorphonuclear neutrophils to Calicophoron daubneyi.jpeg حسب Liliana M. R. Silva (9291971)

"…Bovine neutrophil total adenosine triphosphate concentration significantly decreased after exposure to CdAg 100 µg/mL, in line to the observed with the positive control (phorbol myristate acetate/ionomycin). …"

Image 3_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff حسب José De Jesus Bravo-Silva (21898316)

"…</p>Results<p>Melatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. …"

Image 8_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif حسب Ying Dong (41989)

"…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …"

Table 1_Factors influencing net ecosystem carbon change in cold-temperate coniferous forests of the Da Xing’an Mountains: analysis across developmental stages based on stand, struc... حسب Zirui Wang (8783819)

"…</p>Methods<p>Using data from the National Forest Continuous Inventory (NFCI, 2005–2010) in the eastern Da Xing’an Mountains, we analyzed the effects of stand characteristics, structural diversity, and environmental variables on Net Ecosystem Carbon Change (NECC) across a spectrum of developmental stages, from young to overaged forests.…"

Table 1_MicroRNAs regulate alveolar macrophage homeostasis and its function in lung fibrosis.xlsx حسب Nirmal Parajuli (751983)

"…Our recent study found that the loss of miRNAs in embryonic progenitors significantly decreased the number of TR-AMs in late-stage embryos, indicating that miRNAs are necessary for TR-AM development. …"

Table 1_Dynamic changes in platelet counts and psychological state in ITP patients after COVID-19 infection.docx حسب Xiaoli Chen (102563)

"…Introduction<p>At the end of 2022, the COVID-19 wreaked havoc in China as well as around the world. Here, we focused on the dynamic changes in platelet kinetics and psychological state in ITP patients before and after infection with COVID-19.…"

Image 2_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff حسب José De Jesus Bravo-Silva (21898316)

"…</p>Results<p>Melatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. …"

Shikonin promotes ferroptosis though NSUN2-mediated m⁵C methylation modification of TFRC in acute myelocytic leukemia حسب Shuyu Chen (4579207)

"…To assess cell viability and death, we employed Cell Counting Kit-8 and propidium iodide staining. …"

Data Sheet 1_Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis.pdf حسب Takuya Murao (114383)

"…Additionally, OP18-treated septic mice demonstrated reduced blood organ injury markers, decreased proinflammatory cytokine levels, attenuated ALI, and improved survival. …"

Data Sheet 1_Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke.zip حسب Fengli Ye (22123540)

"…Machine learning identified four hub genes—LEF1, ITGAX, BLVRB, and ATF4. All were significantly upregulated in ICH tissues and plasma, correlating with immune cell infiltration. …"

Image 3_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.tiff حسب Sadia Hamera (22524803)

"…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …"

Image 11_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif حسب Ying Dong (41989)

"…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …"

Data Sheet 5_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf حسب Sadia Hamera (22524803)

"…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …"

Image 3_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif حسب Ying Dong (41989)

"…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …"