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linear decrease » linear increase (Expand Search)
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8222
Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders
Published 2025“…We have developed a potent GPR119 agonist, MKP10241, which has elevated cyclic adenosine monophosphate (cAMP) levels in the GPR119 expressing cell line and reduced blood glucose levels and HbA1c in acute models and a chronic diabetic mouse model. …”
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8223
Data Sheet 1_The effects of sleep deprivation on cognitive flexibility: a scoping review of outcomes and biological mechanisms.docx
Published 2025“…Background<p>Sleep is vital for physical and mental health, yet sleep deprivation is a widespread issue that may impair cognitive flexibility, leading to rigid thinking and slower decision-making. …”
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8224
Supplementary file 2_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx
Published 2025“…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …”
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8225
Supplementary file 3_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx
Published 2025“…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …”
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8226
Table 2_Association of hypertensive disorders of pregnancy with offspring cardiometabolic indicators: a systematic review and meta-analysis.docx
Published 2025“…Additionally, these offspring demonstrated a decreased likelihood of elevated homeostasis model assessment of insulin resistance (OR: 0.58; 95% CI: 0.34–0.98; P < 0.05). …”
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8227
Table 1_Association of hypertensive disorders of pregnancy with offspring cardiometabolic indicators: a systematic review and meta-analysis.doc
Published 2025“…Additionally, these offspring demonstrated a decreased likelihood of elevated homeostasis model assessment of insulin resistance (OR: 0.58; 95% CI: 0.34–0.98; P < 0.05). …”
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8228
Supplementary file 1_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx
Published 2025“…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …”
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8229
Presentation 1_Ischemia-reperfusion injury with a model of porcine whole-blood ex-vivo lung perfusion.pptx
Published 2025“…Neutrophils decreased more in the long CIT group (mean difference, −744.02 cells/mm<sup>3</sup>; 95% CI, −1,343.11 to −144.92; P = 0.017), suggesting sequestration in the lung parenchyma. …”
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8230
Data that underlies this paper.
Published 2025“…<div><p>Background</p><p>Sporotrichosis is a subcutaneous mycosis caused by members of the genus <i>Sporothrix</i>, among which <i>Sporothrix globosa</i> (<i>S. globosa</i>) is the predominant etiological agent in Asia. …”
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8231
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8232
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8233
Table_1_Partnership and relationship happiness in endometriosis related chronic pelvic pain: a multicenter case–control study.docx
Published 2024“…</p>Conclusion<p>Given the significance of partnership in dealing with chronic diseases and the connection between symptoms of endometriosis and a decrease in partnership quality, it is essential to incorporate strategies that alleviate the negative impacts on relationships for both partners into medical support.…”
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8234
Docetaxel and quercetin-loaded lipid nanocarrier optimized by quality by design for glioblastoma therapy: a ligand-conjugated and therapeutic repurposing approach
Published 2025“…Compared to non-conjugated NLC and (DTX-QUR) suspension (SUS), Tf-(DTX-QUR) NLC showed 3.6- and 5.8-fold decrease in IC<sub>50</sub>, respectively. Cellular uptake studies demonstrated significantly (<i>***p < 0.001</i>) high internalization of Tf-conjugated NLC to U87-MG cells. …”
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8235
Table 1_Interobserver variability in organ delineation on radiotherapy treatment planning for nasopharyngeal carcinoma: A dosimetric and prognostic analysis.docx
Published 2025“…Compared to standard delineations, all four physicians showed decreased TCPs (average decrease in ΔTCP >1%) and a significant increase in NTCPs of OARs. …”
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8236
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8237
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8238
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8239
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8240
Effects of activators and inhibitors on TcPiezo channels.
Published 2025“…Downregulation of <i>TcPiezo2</i> expression (+Tet) showed a significant decrease of lysosomal Ca<sup>2+</sup> release as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1013105#ppat.1013105.g004" target="_blank">Fig 4A</a>. …”