Search alternatives:
linear decrease » linear increase (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
linear decrease » linear increase (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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Quantitative Proteomics Unveils the Synergistic Effects of Combination Drugs on Cytoskeleton Composition and Autophagy-Mediated Cell Death in Neuroblastoma
Published 2025“…The mRNA expression levels of several genes predicted by LINCS also decreased. To comprehensively understand the mechanism behind superior efficacy of the combination therapy compared to monotherapy, we performed quantitative proteomics with tandem mass tag labeling and identified 3416 proteins from 20,623 peptides. …”
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The spheroid assay is used to assess long-term effects of therapy on tumor cell by culturing the tumor cells in a micro-mass, which is a 3D tumor mass used as a surrogate for in vi...
Published 2025“…<p>(A) MCF7 tumor cell micro-mass cultures (purple staining) treated with 0-, 1-, 2-, 2.5-, 5-, and 10-mM N-allyl noroxymorphone doses, after 336-hours, produced a significant decrease of 41.9% and 68.1% in micro-mass areas for the 5- and 10-mM N-allyl noroxymorphone concentrations, respectively (* = p < 0.014 and **** = p < 0.0001). …”
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Data extracted from included studies for the systematic review and meta-analysis.
Published 2025Subjects: -
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Specifications and outcomes of clinical trial studies included in the meta-analysis.
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