Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Effects of injury on exploratory behavior. by Ella R. Dockendorf (21533334)

Livestock–Crop–Mushroom (LCM) Circular System: An Eco-Friendly Approach for Enhancing Plant Performance and Mitigating Microbiological Risks by Dong Liu (115204)

“…Mushroom production using agroforestry biowaste is a great green cycling agriculture alternative. …”

Retention and extinction of operant learning. by Ella R. Dockendorf (21533334)

Image 1_A comparison of clinical outcomes following kyphoplasty for osteoporotic compression fractures of the thoracic and lumbar spine: a systematic review and meta-analysis.jpeg by Michael R. Kann (22070273)

“…Across studies, the primary risk of bias was due to confounding variables, resulting in a serious risk of bias in 12 studies (48.0%).</p>Discussion<p>Kyphoplasty provides comparable outcomes in thoracic and lumbar VCFs, with no clinically significant differences in pain relief or procedural effectiveness. …”

Table 1_A comparison of clinical outcomes following kyphoplasty for osteoporotic compression fractures of the thoracic and lumbar spine: a systematic review and meta-analysis.docx by Michael R. Kann (22070273)

“…Across studies, the primary risk of bias was due to confounding variables, resulting in a serious risk of bias in 12 studies (48.0%).</p>Discussion<p>Kyphoplasty provides comparable outcomes in thoracic and lumbar VCFs, with no clinically significant differences in pain relief or procedural effectiveness. …”

Catalytic CO₂ Capture Performance of a MEA-EAE-DEEA Trisolvent in a Hot Silicon Oil-Based Pilot Plant by Yu Li (183836)

“…To implement an energy-efficient combination of CO₂ capture technology, the pilot plant studies were conducted in preparation of commercialization of CCUS demonstration plants, during which a set of specific amine blends with various catalytic packing was employed. …”

Table 1_Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study.docx by Roberto U. Cofresí (20800094)

“…</p>Results<p>Although IC performance (accuracy) was numerically lower for the LS group (M[SD] = 0.527[0.125]) compared to the HS group (M[SD] = 0.595[0.124]), no significant difference was detected [t(30) = 1.55, p = 0.132]. …”

Table 2_Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study.docx by Roberto U. Cofresí (20800094)

“…</p>Results<p>Although IC performance (accuracy) was numerically lower for the LS group (M[SD] = 0.527[0.125]) compared to the HS group (M[SD] = 0.595[0.124]), no significant difference was detected [t(30) = 1.55, p = 0.132]. …”

Data Sheet 1_A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analy... by Jianyu Chen (2624254)

IFN-responsive and anti-viral pathways are induced in γδ T cells post-HIV-1 acquisition. by Gina L. Griffith (20649097)

Update on trimethylamine N-oxide (TMAO) as a piezolyte and cryoprotectant: its role in a depth limit for marine fishes and loss from hadal fish during capture by Paul Yancey (14354982)

“…<p dir="ltr"><b>I</b><b>NTRODUCTION</b></p><p dir="ltr">Trimethylamine N-oxide (TMAO) is a small organic molecule found at osmotically-significant concentrations in many marine animal taxa. …”

Data Sheet 1_Development and validation of a sliding type continuous passive motion automation device for evaluation and rehabilitation of frozen shoulder: a pilot study.pdf by Jewoo Lee (22028855)

“…Passive stiffness in the intervention group significantly decreased in abduction (p = 0.010) and external rotation (p < 0.001). …”

Table 1_Efficacy and safety of combination of frankincense and botulinum toxin in the treatment of blepharospasm: a protocol for a single-centre, open-label, randomized, controlled... by Shiyuan Gong (22754579)

“…Symptom improvement is defined as a decrease of one point or more in the Jankovic Rating Scale severity score compared to baseline in patients with BSP. …”

Supplementary file 1_Phase angle as a predictor of prolonged length of hospital stay and adverse outcomes in elderly medical inpatients: a retrospective cohort study.docx by Jia Liu (41593)

“…Adverse event rates across the PhA tertiles (T1–T3) were 32.9%, 18.6%, and 5.6%, respectively, indicating a significant decrease in event incidence as PhA values increased. …”

Table 1_A population database analysis to describe the residual burden of varicella in Italy—a high vaccination coverage area—from 2004 to 2022.docx by Elisa Barbieri (115023)

“…In the Veneto Region, following the implementation of VV in 2006, the IR significantly decreased by 20.5 annually (95% CI: −23.4, −17.5), ranging from 50.2 per 1,000 person-years in 2006 to 1.2 per 1,000 person-years in 2022.…”

Data Sheet 1_Artificial intelligence–enhanced mapping of the international classification of functioning, disability and health via a mobile app: a randomized controlled trial.zip... by Zhandos Kurban (21985553)

“…A total of 185 adult inpatients (≥18 years) were randomized to either a control group using paper questionnaires or an experimental group using the MedQuest app. …”

Developmental change in 5-HT_1A binding in known cause of death controls (predischarge and postdischarge combined). by Hannah C. Kinney (10280975)

“…Binding in these nuclei are visually (top row) and quantitatively (bottom row) decreasing with PC age, the latter shown with plots of 5-HT_1A binding vs PC age. …”