First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

Global divergent responses of soil heterotrophic respiration to nitrogen deposition by Peng Guo (13816147)

“…Using machine learning, we predicted the global Δ<i>R</i>_H following a 10% increase in atmospheric N deposition and observed significant heterogeneity (–32.3% to +142%). …”

DataSheet1_Feasibility exploration of GSH in the treatment of acute hepatic encephalopathy from the aspects of pharmacokinetics, pharmacodynamics, and mechanism.DOCX by Kangrui Hu (18718429)

“…Building on this premise, we posited the hypothesis that GSH could be a promising candidate for treating acute hepatic encephalopathy (AHE). …”

Recognizing the biological barriers and pathophysiological characteristics of the gastrointestinal tract for the design and application of nanotherapeutics by Shan Li (110392)

“…Therapeutics for GIT disease treatment face multiple biological barriers, which significantly decrease the efficacy of therapeutics. …”

DataSheet1_Chronic exposure to inhaled vaporized cannabis high in Δ9-THC suppresses Adderall-induced brain activity.zip by Jack M. Ognibene (19830132)

“…</p>Results<p>Mice exposed to cannabis when compared to placebo showed a decrease in brain activation to Adderall. The blunted Adderall response was characterized by a decrease in positive BOLD signal and increase in negative BOLD. …”

Supplementary Material for: Long-term trends in incidence, attack rates, and early case-fatality of spontaneous intracerebral hemorrhage. Dijon Stroke Registry (1985-2022) by figshare admin karger (2628495)

“…A similar trend was noted in attack rates, with a peak during 2011-2016 (27.9/100,000/year; ARR: 1.79 95% CI: 1.47-2.20, p<0.001) and a decrease in the most recent period (23.2/100,000/year; ARR: 0.83; 95% CI: 0.69-0.99, p=0.04). …”

Image 4_Neuropeptide Y neurons in the basolateral amygdala project to the nucleus accumbens and stimulate high-fat intake.jpeg by Shunji Yamada (5543327)

“…The optogenetic inactivation of BLA NPY neurons projecting to the NAc caused a significant decrease in HFD intake for a 1-h period, while optogenetic activation of these neurons induced the opposite effect. …”

Image 1_Neuropeptide Y neurons in the basolateral amygdala project to the nucleus accumbens and stimulate high-fat intake.jpeg by Shunji Yamada (5543327)

“…The optogenetic inactivation of BLA NPY neurons projecting to the NAc caused a significant decrease in HFD intake for a 1-h period, while optogenetic activation of these neurons induced the opposite effect. …”

Table 1_Case Report: Novel treatment approach for severe interstitial lung disease in type 3 Gaucher disease.docx by Vincenza Gragnaniello (13847017)

“…Furthermore, we observed a decrease in inflammatory biomarkers, such as TNF-alpha and Pp38 MAPK levels, providing insights into possible pathogenic mechanisms. …”

Image 3_Neuropeptide Y neurons in the basolateral amygdala project to the nucleus accumbens and stimulate high-fat intake.jpeg by Shunji Yamada (5543327)

“…The optogenetic inactivation of BLA NPY neurons projecting to the NAc caused a significant decrease in HFD intake for a 1-h period, while optogenetic activation of these neurons induced the opposite effect. …”

Image 2_Neuropeptide Y neurons in the basolateral amygdala project to the nucleus accumbens and stimulate high-fat intake.jpeg by Shunji Yamada (5543327)

“…The optogenetic inactivation of BLA NPY neurons projecting to the NAc caused a significant decrease in HFD intake for a 1-h period, while optogenetic activation of these neurons induced the opposite effect. …”

Table 1_Microbiological effect of topically applied Weissella cibaria on equine pastern dermatitis.docx by Eva Styková (20507045)

“…The application of the W. cibaria strain was associated with a significant decrease of the genera Staphylococcus, Moraxella, and Rothia in the proliferative group and with a decrease of Streptococcus and Clostridium in both exudative and proliferative groups. …”

Raw_data_N_adition_increased_SOC_PNAS.xlsx by Guoyong Yan (14273351)

“…Thus, we conducted a long-term N addition experiment in a boreal forest to investigate whether and how N addition affects SOC, as well as how this effect is regulated by plant-soil-microbe synergies. …”

DtpT transports structurally diverse di-/tripeptides. by Imran Khan (109715)

“…(<b>C</b>) Transport of 20 peptides was compared by quantifying the change in pyranine fluorescence over the first 30 seconds of the assay. Bars indicate the mean of three replicates ± standard deviation. Coloured bars indicate a change in fluorescence which differs significantly from the no peptide (“Water”) control. …”

<b>Microplastic and drought influence the positive effect of plant diversity on plant biomass production</b> by Jing Man (22181824)

“…</li><li>To unravel the above question and any underlying mechanisms, we conducted a glasshouse experiment. We assembled plant communities along a gradient of plant diversity and then subjected them to four microplastic and drought scenarios in grassland microcosms. …”