Supplementary Material for: Role of melatonin in intestinal mucosal injury induced by chronic restraint stress in mice by figshare admin karger (2628495)

“…Results: Mice subjected to restraint stress presented elevated CORT and NE levels of 141.41% and 151.24%, respectively, and a decreased plasma MT content of 37.12%. Consistent with the decrease in MT levels, we observed a reduction in antioxidant ability and autophagic proteins and increased apoptotic protein levels in the gut, resulting in injury to the intestinal mucosa, which manifested as reductions in the villus height and the V/C ratio; the number of goblets; the number of mast and PCNA-positive cells; and the expression of tight junction proteins (ZO-1, occludin and claudin-1). …”

Supplementary Material for: Acute myelin oligodendrocyte glycoprotein (MOG)-IgG optic neuritis without optic nerve enhancement by Jeyanathan B. (20374227)

“…While acute MOG-ON usually presents with optic nerve enhancement, recognizing atypical presentations is critical in accurate diagnosis and effective management. Case Presentation: We herein present a case of a 67-year-old woman presenting with sudden decrease in vision in the right eye. …”

Table 1_Antimicrobial susceptibility profiles of commensal Clostridium perfringens isolates from chickens in Hungarian poultry farms between 2022 and 2023.docx by Ádám Kerek (14263613)

“…</p>Methods<p>In this study, we aimed to assess the antibiotic susceptibility of commensal Clostridium perfringens (C. perfringens) strains (n = 146) isolated from largescale poultry farms in Hungary, using minimum inhibitory concentration (MIC) determinations. …”

Supplementary file 1_Global, regional, and national burdens of MDR-TB attributable to smoking from 1990 to 2021 with a prediction from 2022 to 2050.docx by Du Dan (22274296)

“…Objective<p>The aim was to offer a comprehensive epidemiological assessment of the global prevalence and the smoking-related Multidrug-resistant tuberculosis (MDR-TB) disease burden from 1990 to 2021 and to forecast the trends in smoking burden over three decades.</p>Methods<p>We compared the burden of smoking-related MDR-TB and temporal trends by gender, age, socio-demographic index (SDI), region, and country. …”

Table1_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Video 2_Progressive encephalomyelitis with rigidity and myoclonus after thymectomy in a woman with myasthenia gravis.mp4 by Lixia Qin (3358520)

“…The patient was treated with intravenous methylprednisolone, oral clonazepam, and tacrolimus, which resulted in significant clinical improvement. A 2-year follow-up demonstrated sustained recovery, accompanied by a decrease in GAD65 antibody titers. …”

Data Sheet 2_Investigating the impact of microcalcification size and volume on collagenous matrix and tissue mechanics using a tissue-engineered atherosclerotic cap model.docx by Imke L. Jansen (22089944)

“…To mimic human microcalcification size and volume, hydroxyapatite microparticles, in two size ranges (diameter up to 5 μm or up to 50 μm) and two volumes (1 v/v% and 5 v/v%) were incorporated homogenously throughout the tissue-engineered model. 5 v/v% of particles caused a significant lowering of the mechanical properties as was shown by a decrease in stiffness and ultimate tensile stress under uniaxial tensile loading. …”

Data Sheet 1_Non-stationary response of Pacific saury (Cololabis saira) in the northwestern Pacific to climate variability.docx by Chang Cao (2592700)

“…The dynamics of Pacific saury from 1970 to 2021 could be divided into four periods: the 1970s and 1980s when the Siberian High and the intensification of the East Asian winter monsoon drove down the water temperature, providing a suitable habitat and resulting in an increase in resource abundance; In the 1990s, the rise in temperature led to a reduction in resource abundance; At the beginning of the 21st century, the enhancement of the Siberian High brought about a suitable habitat, and the resource abundance showed a significant increase; The unfavorable high water temperature environment in the 2010s caused the resource abundance to decrease once again. …”

Repetitive stress induces a reduction in sound-evoked activity that develops as the stressor becomes chronic. by Ghattas Bisharat (20706928)

“…(b) Change in activity across sessions per tracked cell in response to 40, 60, and 70 dB white noise. We found a negative slope in most cells especially for mid-intensities, indicating a decrease in activity as the stress becomes chronic (<i>t</i> test for 40 dB <i>p</i> = 0.36, for 60 dB <i>p</i> = 9.3 × 10⁻¹², and for 70 dB <i>p</i> = 0.00750). …”

DataSheet1_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Exposure to environments with different norms changes participants’ behavior. by Claire Lugrin (21156528)

“…Each participant faced one of four environments. We varied the type of norm that was manipulated (descriptive versus prescriptive norms) and the direction of the change (increased or decreased prosociality). …”

Video 1_Progressive encephalomyelitis with rigidity and myoclonus after thymectomy in a woman with myasthenia gravis.mp4 by Lixia Qin (3358520)

“…The patient was treated with intravenous methylprednisolone, oral clonazepam, and tacrolimus, which resulted in significant clinical improvement. A 2-year follow-up demonstrated sustained recovery, accompanied by a decrease in GAD65 antibody titers. …”

Image 1_Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis.tiff by Junxian Hu (8158044)

“…CRT also exhibits distinct roles depending on its subcellular localization. In this study, we observed that under low hydrostatic pressure, TRPV4 activation and subsequent calcium influx led to an increase in CRT synthesis and a significant rise in its cytosolic expression. …”

DataSheet2_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Image 1_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…This study employed a multi-omics approach, integrating single-cell and bulk RNA sequencing from 21 sepsis samples and Escherichia coli-induced sepsis datasets, alongside bioinformatics, machine learning, and experimental validation in a rat model and human peripheral blood. We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Image 2_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…This study employed a multi-omics approach, integrating single-cell and bulk RNA sequencing from 21 sepsis samples and Escherichia coli-induced sepsis datasets, alongside bioinformatics, machine learning, and experimental validation in a rat model and human peripheral blood. We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Data Sheet 1_Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis.zip by Junxian Hu (8158044)

“…CRT also exhibits distinct roles depending on its subcellular localization. In this study, we observed that under low hydrostatic pressure, TRPV4 activation and subsequent calcium influx led to an increase in CRT synthesis and a significant rise in its cytosolic expression. …”

Table2_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.XLSX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Table3_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.XLSX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Supplementary Material for: Global, regional, and national epidemiology of Idiopathic Childhood Epilepsy from 1990 to 2021 by figshare admin karger (2628495)

“…Regionally, Southern Latin America saw the largest increase in incidence (EAPC, 0.49), and Eastern Europe observed the most significant mortality decrease (EAPC, -4.65). Ecuador reported the highest incidence rate, Tajikistan the highest mortality, and Zambia the highest DALYs in 2021. …”