DataSheet1_Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters.PDF حسب Safaa Yehia Eid (17768736)

"…In MCF-7/ADR and MDA-MB-231/ADR cells, COP (31 μM) enhanced DOX cytotoxicity with CI (0.77 and 0.75), RR (2.58 and 3.33), and IB suggesting synergism. COP significantly inhibits ABCT function in resistant BC cell lines, increases Rho123 accumulation, and decreases efflux more than VER; 2.1 and 1.2-fold, respectively. …"

Table 2_Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets.docx حسب Hongyu Zhou (352858)

"…Western blot analysis further confirmed DHM-mediated suppression of apoptosis through regulation of p53, Bax, cleaved caspase-3, and Bcl-2 expression. High-dose DHM significantly attenuated retinal thinning (10.7% reduction), decreased pigment loss, and ameliorated structural disorganization in the outer nuclear layer (ONL). …"

Image7_Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection.JPEG حسب Jacob Raiten (20021262)

"…Additionally, gain and loss experiments using a PD-L1 inhibitor (BMS-1) were conducted to investigate cellular expression profiles in vitro and cell transplantation outcomes in vivo. …"

Table 1_Berberine alleviates atherosclerosis by modulating autophagy and inflammation through the RAGE-NF-κB pathway.docx حسب Peng Zhang (2071)

"…Introduction<p>Lipid accumulation and foam cell formation are significant features that expedite the progression of atherosclerosis (AS). …"

In sepsis-associated cardiotoxicity, remifentanil reduces oxidative stress, inflammation, and apoptosis to maintain mitochondrial biogenesis by inhibiting NFkB and Cas-3 immunoexpr... حسب Muhammet Yusuf TEPEBAŞI (22576416)

"…<p>Sepsis-induced cardiotoxicity (SIC) is a critical complication characterized by inflammation, oxidative stress, and apoptosis, leading to myocardial dysfunction. …"

Image1_Neutrophil-activating protein in Bacillus spores inhibits casein allergy via TLR2 signaling.jpeg حسب Zhuwei Liang (8762337)

"…Inactivated NAP spores polarized BMDMs to the M1 phenotype and enhanced cytokine expression, which were inhibited by a TLR2 neutralizing antibody.</p>Conclusion<p>NAP offers a new strategy in the treatment of CAS allergy by inhibiting the Th2 response, while eliciting macrophages to promote Th1 immune responses.…"

Table 1_Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets.docx حسب Hongyu Zhou (352858)

"…Western blot analysis further confirmed DHM-mediated suppression of apoptosis through regulation of p53, Bax, cleaved caspase-3, and Bcl-2 expression. High-dose DHM significantly attenuated retinal thinning (10.7% reduction), decreased pigment loss, and ameliorated structural disorganization in the outer nuclear layer (ONL). …"

Table 1_Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice.docx حسب Xue-Ying Zhang (144147)

"…These mice were fed with a high-fat diet for 9 weeks to induce inflammation. …"

Data Sheet 1_An active ingredient from the combination of Corydalis Rhizoma and Paeoniae Radix Alba relieves chronic compression injury-induced pain in rats by ameliorating AR/Mboa... حسب Ze-Ming Wang (9572399)

"…</p>Results<p>The results demonstrated that YB60 significantly decreased inflammatory cytokine levels both in cellular models and rat serum, while concurrently elevating pain thresholds in CCI rats. …"

Image5_Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection.JPEG حسب Jacob Raiten (20021262)

"…Additionally, gain and loss experiments using a PD-L1 inhibitor (BMS-1) were conducted to investigate cellular expression profiles in vitro and cell transplantation outcomes in vivo. …"

Image6_Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection.JPEG حسب Jacob Raiten (20021262)

"…Additionally, gain and loss experiments using a PD-L1 inhibitor (BMS-1) were conducted to investigate cellular expression profiles in vitro and cell transplantation outcomes in vivo. …"

Differential mRNA expression of key metabolic and stress response genes in the <i>MYH7</i> Q315R mice. حسب Shinya Takarada (8655066)

"…Clustering maps show significant changes in RNA expression (p < 0.05) greater than twofold or less than −2.0-fold (A and C). …"

Depletion of viral UL87 LTF in late infection does not affect viral long promoter transcription. حسب Qiaolin Hu (8677473)

"…<b>(B)</b> UCSC Genome Browser of the MIE promoter/enhancer and downstream region show that dTag degrader treatment significantly decreased transcription from the LTF-dependent UL124 promoter and enhancer promoter EP2 (gold arrowheads). …"

Supplementary file 1_Disproportionality analysis of taste disorders using the FDA adverse event reporting system and Japanese adverse drug event report databases.docx حسب Yoji Kyotani (599686)

"…The hazard for clarithromycin remained constant throughout administration, while the hazards for the other drugs decreased over time. Logistic regression analysis confirmed significant associations between the drugs and taste disorders, even after adjusting for age and sex. …"

Model inputs. حسب Natalia Serpetti (5260715)

"…The spatial/temporal model successfully simulated the overall ongoing declining dynamics of the Black Sea ecosystem as the biomasses of the majority of the functional groups had significant observed decreasing trends during the simulation period. …"

DataSheet1_Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment.PDF حسب Larysa Natrus (9397898)

"…While there was a significant inhibition of proliferation in T2DM and, in greater extent, after metformin and PA monotherapies, differential influence on apoptosis in the SI was observed. …"

Table 7_Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto’s thyroiditis: insights from efferocytosis regulation.xlsx حسب Jiahao Zhou (11385383)

"…Moreover, TCM offers significant benefits in regulating lipid metabolism and decreasing systemic inflammation.…"

Table 9_Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto’s thyroiditis: insights from efferocytosis regulation.xlsx حسب Jiahao Zhou (11385383)

"…Moreover, TCM offers significant benefits in regulating lipid metabolism and decreasing systemic inflammation.…"

Table 2_Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto’s thyroiditis: insights from efferocytosis regulation.xlsx حسب Jiahao Zhou (11385383)

"…Moreover, TCM offers significant benefits in regulating lipid metabolism and decreasing systemic inflammation.…"

Table 4_Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto’s thyroiditis: insights from efferocytosis regulation.xlsx حسب Jiahao Zhou (11385383)

"…Moreover, TCM offers significant benefits in regulating lipid metabolism and decreasing systemic inflammation.…"