Data Sheet 1_Potential cerebrospinal fluid metabolomic biomarkers and early prediction model for Parkinson’s disease.docx by Yifan Zhang (119570)

“…A bidirectional causal relationship exists between genetically determined PD susceptibility and metabolites.…”

Table 5_Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990–2021): results from the global burden of disease study.docx by Lili Deng (152262)

“…Significantly, reductions were observed in both mortality and disability-adjusted life years (DALYs) associated with pediatric PAH, with mortality decreasing by 57.66% and DALYs by 63.59% over the study period, indicating progress in mitigating the disease burden. …”

Table 2_Prognostic alternative mRNA splicing in lung adenocarcinoma.xlsx by Panke Su (22636301)

“…High-risk patients, identified by the signature, showed significantly decreased stromal, immune, and combined scores; increased tumor purity (P< 0.001); a reduced prevalence of various immune cell types; diminished immune cell activity; and decreased expression of immune checkpoint genes. …”

Data Sheet 1_Prognostic alternative mRNA splicing in lung adenocarcinoma.xlsx by Panke Su (22636301)

“…High-risk patients, identified by the signature, showed significantly decreased stromal, immune, and combined scores; increased tumor purity (P< 0.001); a reduced prevalence of various immune cell types; diminished immune cell activity; and decreased expression of immune checkpoint genes. …”

Table 1_Prognostic alternative mRNA splicing in lung adenocarcinoma.xlsx by Panke Su (22636301)

“…High-risk patients, identified by the signature, showed significantly decreased stromal, immune, and combined scores; increased tumor purity (P< 0.001); a reduced prevalence of various immune cell types; diminished immune cell activity; and decreased expression of immune checkpoint genes. …”

Data Sheet 1_α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT–FOXO1–CD36 pathway.pdf by Xue Bai (129175)

“…Oxidative stress and lipid metabolism disorder-induced myocardial cell damage are part of the pathogenesis of DCM. In this study, we investigated the effects of alpha-mangostin (A-MG), a natural antioxidant extracted from mangosteen peel, on in vitro and in vivo DCM models.…”

Baseline characteristics of the four groups. by Chao Yang (174810)

“…When the HAR was at a low level, mortality within 28 days after ICU admission decreased significantly as the HAR increased. …”

Flow of included patients through the trial. by Chao Yang (174810)

“…When the HAR was at a low level, mortality within 28 days after ICU admission decreased significantly as the HAR increased. …”

Cox proportional hazards modeling. by Chao Yang (174810)

“…When the HAR was at a low level, mortality within 28 days after ICU admission decreased significantly as the HAR increased. …”

Molecular characterization of zinc metalloproteinase Nas-14 from Trichinella spiralis and its participation in intestinal invasion by Qingbo Lv (21676001)

“…In addition, the direct incubation of rTsNas14 with claduin-1 showed that rTsNas14 could significantly degrade claudin-1. In vivo studies have demonstrated that inhibition of TsNas14 expression significantly impairs the infectivity of T. spiralis in mice, resulting in a decreased AW and muscle larval burden. …”

<b>不同辣椒</b><b>chili</b><b>straw on growth performance, rumen fungal flora structure, function and economic benefits of sheep</b> by Jinlong Li (20481890)

“…Key findings include:(1) Dry matter intake (DMI) increased significantly in the 10% CS group (P<0.01), whereas DMI and final body weight decreased in the 20% CS group (P<0.01 or P<0.05); Final body weight and average daily gain (ADG) showed an upward trend in the 10% CS group (P > 0.05), while ADG displayed a downward trend in the 20% CS group (P>0.05); (2) The ACE and Chao1 indices were significantly elevated in the 20% CS group (P<0.05); (3) Principal coordinates analysis (PCoA) and non-metric multidimensional scaling (NMDS) revealed distinct clustering of the 20% CS group compared to the control (CON) group; (4) Relative abundances of Ascomycota and Cladosporium increased, whereas those of Basidiomycota and Kazachstania decreased in CS-supplemented groups (P>0.05); (5) FUNGuild functional prediction indicated that rumen fungi were predominantly symbiotrophic, with increased relative abundances of symbiotrophic and pathotrophic fungi and decreased saprotrophic fungi in CS groups (P>0.05). (6) The gross profit and net profit of CS10 % group increased. …”

Table 1_Effects of xylooligosaccharide supplementation on performance, intestinal morphology, antioxidant capacity and cecal microflora in weaning pigs.docx by Wenfeng Ma (6645200)

“…Compared with the CON group, the cecal microbial community diversity of weaned pigs with XOS supplementation significantly differed (p < 0.05). XOS supplementation reduced the relative abundance of Proteobacteria and Spirochaetes in the cecum of weaned pigs, and improved the relative abundance of Lactobacillus and Ruminococcus in the cecum of weaned pigs, but decreased the relative abundance of Spirillaceae NK4A136, Prevoid group, and AC2044 group of Spirillaceae (p < 0.05). …”

Data Sheet 1_Huoxue-Jiangtang decoction ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced rats.pdf by Maosheng Lee (13041531)

“…Moreover, the levels of glycogen synthetase (GS), hexokinase, superoxide dismutase (SOD), glycogen, and muscle glycogen in the HXJT group significantly increased relative to those in untreated T2DM group, while TNF-α levels decreased observably. …”

Table 1_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.xlsx by Yanling Wen (552195)

“…Notably, the heightened suppressive function of HLA_DR⁺ Tregs in severe COVID-19 patients, with interactions between PF4 and CXCR3, contributed to the homeostasis of HLA_DR⁺ Tregs in severe COVID-19 patients. Furthermore, we observed that Tregs in COVID-19 patients exhibited weakened TCR clonotype expansion, and the suppression of HLA_DR⁺ Tregs with expanded TCR clonotypes in severe COVID-19 cases did not show a significant increase compared to asymptomatic and mild COVID-19 groups. …”

Supplementary file 4_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…Notably, the heightened suppressive function of HLA_DR⁺ Tregs in severe COVID-19 patients, with interactions between PF4 and CXCR3, contributed to the homeostasis of HLA_DR⁺ Tregs in severe COVID-19 patients. Furthermore, we observed that Tregs in COVID-19 patients exhibited weakened TCR clonotype expansion, and the suppression of HLA_DR⁺ Tregs with expanded TCR clonotypes in severe COVID-19 cases did not show a significant increase compared to asymptomatic and mild COVID-19 groups. …”

Supplementary file 5_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…Notably, the heightened suppressive function of HLA_DR⁺ Tregs in severe COVID-19 patients, with interactions between PF4 and CXCR3, contributed to the homeostasis of HLA_DR⁺ Tregs in severe COVID-19 patients. Furthermore, we observed that Tregs in COVID-19 patients exhibited weakened TCR clonotype expansion, and the suppression of HLA_DR⁺ Tregs with expanded TCR clonotypes in severe COVID-19 cases did not show a significant increase compared to asymptomatic and mild COVID-19 groups. …”

Supplementary file 6_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…Notably, the heightened suppressive function of HLA_DR⁺ Tregs in severe COVID-19 patients, with interactions between PF4 and CXCR3, contributed to the homeostasis of HLA_DR⁺ Tregs in severe COVID-19 patients. Furthermore, we observed that Tregs in COVID-19 patients exhibited weakened TCR clonotype expansion, and the suppression of HLA_DR⁺ Tregs with expanded TCR clonotypes in severe COVID-19 cases did not show a significant increase compared to asymptomatic and mild COVID-19 groups. …”

Supplementary file 1_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…Notably, the heightened suppressive function of HLA_DR⁺ Tregs in severe COVID-19 patients, with interactions between PF4 and CXCR3, contributed to the homeostasis of HLA_DR⁺ Tregs in severe COVID-19 patients. Furthermore, we observed that Tregs in COVID-19 patients exhibited weakened TCR clonotype expansion, and the suppression of HLA_DR⁺ Tregs with expanded TCR clonotypes in severe COVID-19 cases did not show a significant increase compared to asymptomatic and mild COVID-19 groups. …”

Supplementary file 3_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…Notably, the heightened suppressive function of HLA_DR⁺ Tregs in severe COVID-19 patients, with interactions between PF4 and CXCR3, contributed to the homeostasis of HLA_DR⁺ Tregs in severe COVID-19 patients. Furthermore, we observed that Tregs in COVID-19 patients exhibited weakened TCR clonotype expansion, and the suppression of HLA_DR⁺ Tregs with expanded TCR clonotypes in severe COVID-19 cases did not show a significant increase compared to asymptomatic and mild COVID-19 groups. …”

Supplementary file 2_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…Notably, the heightened suppressive function of HLA_DR⁺ Tregs in severe COVID-19 patients, with interactions between PF4 and CXCR3, contributed to the homeostasis of HLA_DR⁺ Tregs in severe COVID-19 patients. Furthermore, we observed that Tregs in COVID-19 patients exhibited weakened TCR clonotype expansion, and the suppression of HLA_DR⁺ Tregs with expanded TCR clonotypes in severe COVID-19 cases did not show a significant increase compared to asymptomatic and mild COVID-19 groups. …”