Data Sheet 1_Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence.docx by Juan Chen (61123)

“…</p>Conclusion<p>This study integrated meta-analysis, murine model validation, and single-cell transcriptomic profiling to demonstrate a significant reduction of BDNF in CKD. Furthermore, renal BDNF expression decreased locally, predominantly originating from proximal tubule cells, macrophages, and podocytes, possibly epigenetically inhibited by the upregulation of lnc RNA Bdnf-as.…”

Raw data for Fig 3a. by Parisa Afzal Haghjoo (22453647)

Raw data for Fig 4a. by Parisa Afzal Haghjoo (22453647)

Forest plots illustrate the mean difference in; (A) creatinine clearance, (B) eGFR, (C) BUN, and (D) shows relative risk in ARF. by Mohamed R. Abdelraouf (21501468)

Impact of the interaction between sewage pH and CPAM dosage on sewage turbidity. (a) Contour diagram; (b) 3D surface diagram. by Peng Zhao (128233)

Comparison of SpO₂ (A), HR (B), SBP (C), and DP (D) on VT among the three oxygen conditions. by Kazufumi Hisamoto (21416905)

Impact of group 1 and group 2 drugs on hyperglycemia based on HbA1c levels before and after 3 months of administration. by Nadia Gul (249538)

Data Sheet 1_The “best practices for farming” successfully contributed to decrease the antibiotic resistance gene abundances within dairy farms.docx by Barbara Salerno (12894908)

“…Despite similar levels of antibiotic administration (based on veterinary prescription data from the sampled farms) in both sampling campaigns, the total abundance of selected ARGs, particularly bla_TEM and tetA, significantly decreased after the adoption of the farming guidelines.…”

Metabolome data of the discovery cohort. by Feng Gao (3548)

“…The results showed that compared with HC, five metabolites, including DL-stachydrine, D-(+)-pipecolinic acid, furazolidone, L-arginine and 5α-dihydrotestosterone glucuronide were significantly elevated and one metabolite, prenylcysteine, was significantly decreased in the serum of OC, and that the increase in L-arginine and the decrease in prenylcysteine led to impaired urea cycling and a high risk of developing atherosclerosis, respectively. …”

Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents by Marcian E. Van Dort (21374093)

“…Additionally, compound LP-65 demonstrated significant modulation of MEK and mTOR signaling activity in human glioma cells (D54) and human melanoma cells (A375), with a corresponding decrease in cellular proliferation and migration. …”

A bar graph showing the overall colony loss rates and 95% confidence intervals for the 1,786 beekeepers interviewed across the nine Sub-Saharan African countries. by Beatrice T. Nganso (4114768)

Results of redundancy analysis. by Bianhua Zhang (22430652)

“…<div><p>In order to clarify the effects of long-term coal gangue(CG) dump on the surrounding soil bacterial community structure, we selected the CG dump formed during the mining of Tunlan coal mine in Gujiao city, Shanxi province in China as the study area to conduct a comprehensive study, the experimental design included six distinct zones: control soil area with no impaction (NC), undisturbed control sediment area (NL), atmospheric dry and wet deposition area (MC), upstream (MLS), midstream (MLZ) and downstream (MLX) in the leachate flow area (LFA), Using high-throughput sequencing technology and related software analysis, we obtained the following key findings: The heavy metal contents of Cr and Cd were different significantly in MC and NC (p < 0.05),Cr (90.18 mg·kg-1) in MC was higher than that in NC (65.29 mg·kg-1) (p < 0.05), while Cd (0.09 mg·kg-1) was lower than that in NC (0.14 mg·kg-1) (p < 0.05), and there was no significant differences in Cu, Zn, As and Pb between MC and NC (p > 0.05). …”

A brief illustration of the revisions between AJCC TNM eighth and ninth editions. by Aihong Zheng (20571034)

Average Time Between Successive R-wave Peaks (RR Intervals) across pre-interview, interview and post-interview phases for High and Low Clarity and Authority groups: RR decreases fr... by David Vagni (8060432)

Videofluoroscopic swallowing study parameters. by Rie Asayama (693361)

“…Histological analysis demonstrated marked variability in muscle fiber size and a high frequency of central nuclei. Additionally, decreased expression of chloride channel 1 was observed in the masseter muscle, suggesting the presence of myotonia. …”

LncRNA <i>C5orf64</i> polymorphisms (rs12518552 and rs2950218) decreases pulmonary tuberculosis susceptibility by Shilin Xu (1884217)

Deficiency of <i>Irg1</i> decreased lung neutrophils in mice during <i>M</i>. <i>pneumoniae</i> infection. by Cui Wang (141700)

Data Sheet 1_Impact of multiple environmental factors on influenza–like illness in Fujian Province, China, 2015–2023: a multicity study.zip by Xiaoyan Yao (8723622)

“…Introduction<p>Influenza-like illness (ILI) represents a significant global public health challenge influenced by environmental factors. …”

<i>Oenocarpus bacaba</i> palm tree (A) and fruit (B). by Eudes Alves Simões-Neto (19697968)

“…Serological cure was achieved in 34.6% of cases, and IgG titers decreased in 15.3%.</p><p>Conclusions and significance</p><p>We encountered several barriers in managing ACD, including population vulnerability, reliance on outdated diagnostic techniques, lack of standardized molecular biology methods, and limited therapeutic options. …”

related to Fig 5. (A) the total number of eggs in the livers did not differ between BL/6 and Gsdmd-/- mice. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

“…Data are representative of two independent experiments. Significance was determined using a Student’s t-test ***p < 0.0005.…”