Data Sheet 2_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.xlsx by Alexandra Prodea (22617710)

“…The toxicity assessment revealed that triterpenes have in general, insignificant or absent toxicity, with only a small number of studies reporting serious side effects such as leukopenia, hepatotoxicity and mortality at specific doses that were reversed in some cases by the use of carriers, which hold the potential to enhance the therapeutic effect of triterpenes while reducing their systemic toxicity.</p>Conclusion<p>We concluded that the current in vivo evidence does not support the clinical translation of triterpenes for the treatment of breast cancer due to methodological and clinical heterogeneity as well as the lack of toxicity data in a significant number of studies. …”

Table 1_Impact of the Yangtze River on Sediment source-to-sink processes in estuarine bays: a study of the Oujiang River Estuary, SE China.docx by Xia Guang (21570056)

“…Our findings revealed a dynamic pattern of sediment distribution, with the predominant clay minerals in the surface sediment of the offshore area being illite, followed by kaolinite and chlorite, with a minor smectite content. Notably, we observed a gradual increase in the proportions of illite and smectite from the upstream to the estuary, while kaolinite decreased accordingly. …”

Data Sheet 1_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.pdf by Alexandra Prodea (22617710)

“…The toxicity assessment revealed that triterpenes have in general, insignificant or absent toxicity, with only a small number of studies reporting serious side effects such as leukopenia, hepatotoxicity and mortality at specific doses that were reversed in some cases by the use of carriers, which hold the potential to enhance the therapeutic effect of triterpenes while reducing their systemic toxicity.</p>Conclusion<p>We concluded that the current in vivo evidence does not support the clinical translation of triterpenes for the treatment of breast cancer due to methodological and clinical heterogeneity as well as the lack of toxicity data in a significant number of studies. …”

Data Sheet 1_Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.pdf by Dilara Yılmaz (19710658)

“…While these approaches have been applied to aging mice, their effectiveness in prematurely aging mouse models such as PolgA^D257A/D257A (PolgA) has not been completely explored. We demonstrated that frailty became evident in PolgA mice around 40 weeks, validated through body weight loss, reduced walking speed, decreased physical activity, and weaker grip strength. …”

Water bridges by Raman Jangra (19231711)

“…To delineate the structural role of water molecules in shaping the interactions between RNA and proteins, we comprehensively analyzed a dataset of 329 high-resolution crystal structures of RNA–protein complexes to identify water-mediated hydrogen-bonded contacts at the RNA–protein interface. …”

Data Sheet 1_Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood.pdf by Hanane Omichessan (4991552)

“…Serum levels of PFOS and PFOA were measured by liquid chromatography coupled to tandem mass spectrometry.</p>Results<p>We found 64 CpG sites with significant hypomethylation or hypermethylation associated with increased levels of PFOA or PFOS (p-value_Bonferroni < 0.05). …”

Spatial variation and clgassification of anthropogenic soils formed by long-term “<i>Dorotsuke”</i> soil-dressing in Andosols of the Omiya Upland along the Arakawa River, Japan by Shokichi Wakabayashi (3872428)

“…The two anthropogenic horizons exceeded 50 cm in thickness with different soil textures, while one of the other two showed significant mixing with Andosol. The profiles exhibited a vertical attenuation of andic characteristics, including increased bulk density, decreased short-range-order mineral content, and reduced phosphate retention, from the buried Andosol up to the topsoil. …”

TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts by Thuc Ly (12832686)

“…Using both a literature based, and an unbiased approach, we studied the molecular machinery involved in autophagosome trafficking in CAFs. …”

Table_3_Association between tea consumption and stroke in the American adult females: analyses of NHANES 2011–2018 data.XLSX by Yongyue Miao (19925808)

“…Background<p>Epidemiological surveys show that there is a significant gender difference in the incidence of stroke, with females having a noticeably higher rate than males. …”

Table_2_Association between tea consumption and stroke in the American adult females: analyses of NHANES 2011–2018 data.xlsx by Yongyue Miao (19925808)

“…Background<p>Epidemiological surveys show that there is a significant gender difference in the incidence of stroke, with females having a noticeably higher rate than males. …”

Data_Sheet_1_Association between tea consumption and stroke in the American adult females: analyses of NHANES 2011–2018 data.zip by Yongyue Miao (19925808)

“…Background<p>Epidemiological surveys show that there is a significant gender difference in the incidence of stroke, with females having a noticeably higher rate than males. …”

Table_1_Association between tea consumption and stroke in the American adult females: analyses of NHANES 2011–2018 data.docx by Yongyue Miao (19925808)

“…Background<p>Epidemiological surveys show that there is a significant gender difference in the incidence of stroke, with females having a noticeably higher rate than males. …”

Thymoquinone loaded nanoemulgel in streptozotocin induced diabetic wound by Urati Anuradha (20306190)

“…</p> <p>In diabetic wound animal model nanoemulgel showed significant decreased levels of TNF-α, IL-6, MMP-9 and IL-1β. …”

Image 2_Phage therapy for extensively drug resistant Acinetobacter baumannii infection: case report and in vivo evaluation of the distribution of phage and the impact on gut microb... by Jiayao Qu (11309880)

“…In fecal samples, a significant reduction in the Ct value of phages was observed following both phases of bacteriophage treatment, with values decreasing from 35.5 to 22.5 and from 32.6 to 22.7, respectively. …”

Image 1_Phage therapy for extensively drug resistant Acinetobacter baumannii infection: case report and in vivo evaluation of the distribution of phage and the impact on gut microb... by Jiayao Qu (11309880)

“…In fecal samples, a significant reduction in the Ct value of phages was observed following both phases of bacteriophage treatment, with values decreasing from 35.5 to 22.5 and from 32.6 to 22.7, respectively. …”

Image 2_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Cr(VI) stress significant increases in H₂O₂ and MDA levels and significant decreases in antioxidant enzyme activity levels (SOD, GSH-Px, and T-AOC) and energy metabolism-related ATPase activity levels (Na⁺K⁺-ATPase, Ca²⁺-ATPase, and Mg²⁺-ATPase). …”

Image 3_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Cr(VI) stress significant increases in H₂O₂ and MDA levels and significant decreases in antioxidant enzyme activity levels (SOD, GSH-Px, and T-AOC) and energy metabolism-related ATPase activity levels (Na⁺K⁺-ATPase, Ca²⁺-ATPase, and Mg²⁺-ATPase). …”

Table 1_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Cr(VI) stress significant increases in H₂O₂ and MDA levels and significant decreases in antioxidant enzyme activity levels (SOD, GSH-Px, and T-AOC) and energy metabolism-related ATPase activity levels (Na⁺K⁺-ATPase, Ca²⁺-ATPase, and Mg²⁺-ATPase). …”

Image 4_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Cr(VI) stress significant increases in H₂O₂ and MDA levels and significant decreases in antioxidant enzyme activity levels (SOD, GSH-Px, and T-AOC) and energy metabolism-related ATPase activity levels (Na⁺K⁺-ATPase, Ca²⁺-ATPase, and Mg²⁺-ATPase). …”

Image 1_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Cr(VI) stress significant increases in H₂O₂ and MDA levels and significant decreases in antioxidant enzyme activity levels (SOD, GSH-Px, and T-AOC) and energy metabolism-related ATPase activity levels (Na⁺K⁺-ATPase, Ca²⁺-ATPase, and Mg²⁺-ATPase). …”