DataSheet1_Feasibility exploration of GSH in the treatment of acute hepatic encephalopathy from the aspects of pharmacokinetics, pharmacodynamics, and mechanism.DOCX by Kangrui Hu (18718429)

“…Pharmacokinetic studies suggested that AHE modeling led to significant decrease in hepatic and cerebral exposure of GSH and cysteine. …”

Data Sheet 1_Clinical utility of nanopore-targeted sequencing for diagnosing and treating pulmonary infectious diseases from bronchoalveolar lavage fluid.docx by Gen Li (743590)

“…Additionally, prior antibiotic exposure had no influence on the detection efficiency of NTS but significantly hindered that of CMTs. After antibiotic adjustments based on NTS findings, 87.76% of patients showed significant improvement, with a notable decrease in the level of inflammatory markers (CRP, NP, PCT, WBC) post-treatment. …”

Supplementary file 1_Dynamic reconfiguration and transition of whole-brain networks in patients with MELAS revealed by a hidden Markov model.docx by Qingyun Yu (18837625)

“…Based on HMM, fractional occupancies in states 5 and 6 for MELAS were significantly decreased (p < 0.001), but fractional occupancies in states 2, 3, 4, 7, 8, 9, 10, and 11 were significantly increased (p < 0.05), compared to HCs. …”

Data Sheet 2_Clinical utility of nanopore-targeted sequencing for diagnosing and treating pulmonary infectious diseases from bronchoalveolar lavage fluid.xlsx by Gen Li (743590)

“…Additionally, prior antibiotic exposure had no influence on the detection efficiency of NTS but significantly hindered that of CMTs. After antibiotic adjustments based on NTS findings, 87.76% of patients showed significant improvement, with a notable decrease in the level of inflammatory markers (CRP, NP, PCT, WBC) post-treatment. …”

<b>Optimizing Viable Bacteria Detection in Ballast Tank Sediments: Addressing PCR Inhibitors and Relic DNA</b> by 1 Anonymous (21812990)

“…Interestingly, when PMA treatment preceded inhibitor removal, we observed a decrease in 16S rRNA gene copies coupled with an increase in ASV richness, suggesting that PCR inhibitors can compromise PMA's ability to exclude relic DNA. …”

Data Sheet 2_A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury.pdf by Yuichi Akama (17892940)

“…Our data showed that B-1a cell numbers and frequencies in the pleural and peritoneal cavities were significantly decreased in sepsis. Neutrophils co-cultured with B-1a cells significantly increased B-1a cell internalization via trogocytosis. …”

Data Sheet 1_A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury.pdf by Yuichi Akama (17892940)

“…Our data showed that B-1a cell numbers and frequencies in the pleural and peritoneal cavities were significantly decreased in sepsis. Neutrophils co-cultured with B-1a cells significantly increased B-1a cell internalization via trogocytosis. …”

Table1_Elevational patterns of soil organic carbon and its fractions in tropical seasonal rainforests in karst peak-cluster depression region.docx by Bei Zhang (428038)

“…The majority of SOC fractions exhibited an increase with elevation but decrease with soil depth. Notably, only water-soluble organic carbon (WSOC) displayed a decrease with elevation. …”

Data Sheet 1_Characterization of T-cell immune responses against Staphylococcus chromogenes naturally-induced subclinical mastitis in dairy cows.docx by Chen Yu (285930)

“…</p>Results<p>We found that S. chromogenes infection induced an increase in the percentage of γδ T cells and a decrease in CD4⁺CD8⁺ double-positive (DP) T cells within milk cells, while significantly elevating the percentage of γδ T cells expressing CD44. …”

Supplementary file 1_Microbial cross contamination in household laundering and microbial ecology of household washing machines.pdf by Kelly Whitehead (22449349)

“…Machine drying did not significantly decrease microbial loads, whereas the presence of soiled clothing impacted community composition. …”

Table 1_fNIRS, EEG, ECG, and GSR reveal an effect of complex, dynamically changing environments on cognitive load, affective state, and performance, but not physiological stress.xl... by Henrikke Dybvik (11492599)

“…Despite significant differences in cognitive load, we found little between-condition differences in physiological stress response as measured by ECG and EDA. …”

Data Sheet 1_fNIRS, EEG, ECG, and GSR reveal an effect of complex, dynamically changing environments on cognitive load, affective state, and performance, but not physiological stre... by Henrikke Dybvik (11492599)

“…Despite significant differences in cognitive load, we found little between-condition differences in physiological stress response as measured by ECG and EDA. …”

Table 3_Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster.xlsx by Florance Parweez (22534262)

“…Notably, Sb576 supplementation, but not SbWT or spermidine supplementation, of either young flies or old flies for only three days also enhanced STM without affecting locomotive ability. Furthermore, we showed that Sb576 supplementation also significantly reduced aging-associated STM decline in Dh31R, a mutant strain lacking the diuretic hormone 31 receptor, which exhibits compromised learning and memory.…”

Data Sheet 1_Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss.docx by Joana Saavedra (11327910)

“…We used the AD mouse model AβPPswe/PS1A246E to show that neuronal S100B levels are significantly higher in 10-month-old animals, and cellular assays to demonstrate that Aβ oligomers significantly increase S100B expression in SH-SY5Y cells, but not monomeric or fibrillar Aβ. …”

Table 1_Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster.xlsx by Florance Parweez (22534262)

“…Notably, Sb576 supplementation, but not SbWT or spermidine supplementation, of either young flies or old flies for only three days also enhanced STM without affecting locomotive ability. Furthermore, we showed that Sb576 supplementation also significantly reduced aging-associated STM decline in Dh31R, a mutant strain lacking the diuretic hormone 31 receptor, which exhibits compromised learning and memory.…”

Table 2_Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster.xlsx by Florance Parweez (22534262)

“…Notably, Sb576 supplementation, but not SbWT or spermidine supplementation, of either young flies or old flies for only three days also enhanced STM without affecting locomotive ability. Furthermore, we showed that Sb576 supplementation also significantly reduced aging-associated STM decline in Dh31R, a mutant strain lacking the diuretic hormone 31 receptor, which exhibits compromised learning and memory.…”

Table 1_Effect of high-intensity intermittent rehabilitation training on physical function, gut microbiome and metabolite after percutaneous coronary intervention in patients with... by Lei Jiang (73366)

“…In addition, we identified 29 gut microbial species and 30 plasma metabolites that were differentially enriched between the two groups, with some showing a significant impact on 6MWT performance.…”

DataSheet1_Targeting AXL cellular networks in kidney fibrosis.docx by Sturla M. Grøndal (20102511)

“…</p>Results<p>Preventive treatment with bemcentinib significantly attenuated fibrosis in the UUO model. The anti-fibrotic effect correlated with a decrease in mesangial cells and inhibition of innate immune cell infiltration, while the proportion of epithelial cells increased. …”

Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy by Fang Ye (112854)

“…Molecular simulations revealed that PAE’s tertiary amine protonation affected the self-assembly process, modifying hydrophobicity and resulting in larger, loosely packed particles. Furthermore, compared to free PAP-1 or PAP-1 combined with MDR inhibitors, PAP-1-loaded micelles significantly enhanced cytotoxicity and apoptosis induction in Jurkat and B16F10 cells, through mechanisms involving decreased mitochondrial membrane potential and elevated caspase-3 activity. …”

Data Sheet 1_CO2 capture from indoor air for human comfort and sequestration or reuse: a promising step toward sustainable CO2 removal.docx by Krishnendu Maity (1645408)

“…While the aqueous MEA solution experienced significantly larger declines of 54.3% in CO₂ absorption capacity and 34.24% in absorption kinetics, the water-PG-based Arg solution demonstrated promising performance, with a smaller reduction of 31.24% in CO₂ absorption and a 2.13% decrease in kinetics after ten cycles. …”