Data Sheet 1_Photodynamic inactivation of Staphylococcus aureus with rose bengal reduces superantigen activity.docx by Patrycja Ogonowska (5644274)

“…Across in vitro, ex vivo, and murine in vivo models, RB-mediated aPDI significantly decreased S. aureus viability and markedly attenuated the expression and activity of staphylococcal enterotoxins. …”

Data for: Soil microplastics pollution can reduce viral abundance and have less consistent impacts on bacteria by Wen-Wen Huang (22122439)

“…A number of environmental factors may affect viruses and their microbial hosts differentiate. Here we report two experiments that addressed the impacts of microplastics (MP) on viruses and bacteria in soils. …”

Fertilization and herbivore exclusion promote more deterministic processes in plant community assembly on the Qinghai–Tibet Plateau by Wei Zhao (21458114)

“…The results showed that, compared to the control, species richness significantly decreased under fertilization, herbivore exclusion, and their combined treatment, with the greatest decline in species richness observed in the final year of the experiment. …”

Mitigation of Senescence Burden in Doxorubicin-Induced Senescent Endothelial Cells by MitoQ Treatment Through Diminishing Mitochondrial ROS and DNA Damage. by Hossein Abdeahad (22177792)

“…DOXO increased mtROS, decreased mitochondrial mass, and induced senescence. …”

Supplementary Material for: m6A eraser FTO promotes ATF3 expression impairing podocyte autophagy in diabetic nephropathy by figshare admin karger (2628495)

“…Although emerging evidence suggests an important role for m6A RNA modifications in autophagy regulation, their precise function in DN remains unclear. Here, we identify the m6A demethylase FTO as a critical driver of DN. …”

Data Sheet 1_A machine learning model for predicting the risk of diabetic nephropathy in individuals with type 2 diabetes mellitus.docx by Tingting Li (10553)

“…The remaining 8,549 patients were divided into a training set (n = 5,985) and a validation set (n = 2,564) using a simple random sampling method in a 7:3 ratio. Subsequently, we employed LASSO regression to identify variables significantly associated with DKD in T2DM patients. …”

Data Sheet 1_Efficacy and safety of topical minocycline preparations for papulopustular rosacea: a systematic review and meta-analysis.pdf by Awadh Alamri (20970752)

“…This paper was conducted in adherence to PRISMA guidelines. Also, we have registered our protocol in PROSPERO (CRD42023447486). …”

DataSheet_1_FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms.docx by Paula Uittenbogaard (19691794)

“…Treatment with intravenous immunoglobulin (IVIg) significantly decreases the risk of CAA, possibly through competitive binding to Fc-gamma receptors (FcγRs), which reduces the binding of pathological immune complexes. …”

Supplementary file 1_Transcriptome-wide N6-methyladenosinem modifications analysis of chicken cecum in responding to Campylobacter jejuni inoculation.zip by Yanan Zhao (3132906)

“…</p>Results<p>In the S group, the level of proinflammatory cytokines (IL-8, IL-1β, IL-18, TNF-α, IL-17A) and global RNA methylation were significantly decreased (P < 0.05). A total of 30,427 and 30,367 m⁶A peaks were identified in R and S groups, which were primarily located in 3'UTR and CDS regions. …”

Data Sheet 1_Metformin upregulates circadian gene PER2 to inhibit growth and enhance the sensitivity of glioblastoma cell lines to radiotherapy via SIRT2/G6PD pathway.docx by Hailiang Li (740080)

“…Statistical analyses were conducted using Prism software to identify significant group differences.</p>Results<p>We found that differential expressional genes and proteins relating to circadian rhythm were enriched in proteomic or transcriptomic. …”

Table 1_IP-10 acts early in CV-A16 infection to induce BBB destruction and promote virus entry into the CNS by increasing TNF-α expression.docx by Yajie Hu (550783)

“…We observed that the level of IP-10, as well as the TLR3-TRIF-TRAF3-TBK1-NF-κB and RIG-I/MDA5-MAVS-TRAFS-TBK1-NF-κB pathways, which are the upstream of IP-10, were significantly elevated during the course of CV-A16 infection. …”

Supplementary Material for: Head positioning for stroke blood flow augmentation assisting reperfusion therapies (HEAD-START) study by figshare admin karger (2628495)

“…Trendelenburg positioning was maintained for 24h if lesion volume significantly decreased (≥5mL) and stroke reperfusion was suboptimal or undetermined. …”

Additional file 11 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma by Benjamin Lin (120565)

“…Of these categorized genes, 980 and 844 are significantly (DESeq2 FDR < 0.05 and LFC > 1) increased and decreased after treatment with either drug (C). …”

DataSheet1_Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations.pdf by Ashelley Kettyllem Alves de Sousa (20293452)

“…Levels of mitochondrial and total superoxide anion (p < 0.01 and p < 0.05, respectively) and hydrogen peroxide (p < 0.001) were significantly elevated. PS-MP exposure resulted in a reduction in total sulfhydryl content (p < 0.05) and the activities of antioxidant enzymes superoxide dismutase (p < 0.01) and catalase (p < 0.05), while glutathione peroxidase activity increased (p < 0.05), and the oxidized/reduced glutathione ratio decreased (p < 0.05). …”

Data Sheet 1_Epigallocatechin-3-gallate protects against osteoarthritis-induced chondrocytes dysfunction by regulating PLa2g2a.pdf by Mengyuan Dai (9747317)

“…OA model demonstrated that EGCG treatment significantly promoted cartilage repair and increased Pla2g2a expression. …”

Data Sheet 1_Temperature extremes across elevation gradients: evidence from two German mountain observatories.pdf by Monica Ionita (6486275)

“…., 1781–2024) and Zugspitze (2,956 m a.s.l., 1901–2024). We find a pronounced warming at both sites, characterized by significant acceleration in recent decades. …”

Data Sheet 1_Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target.csv by Jie Zheng (31208)

“…In vivo, Gyg1 was markedly upregulated in septic mice, and LNP-mediated siRNA knockdown of Gyg1 significantly improved survival in the LPS model. Mechanistically, Gyg1 knockdown significantly reduced glycogen content in myeloid cells, attenuated IL-6 and TNF-α production, alleviated LPS-induced neutrophil, and modestly decreased CD40 expression in monocytes and dendritic cells. …”

Data Sheet 1_Impact of liposomal bupivacaine on subjective recovery quality after surgery: a meta-analysis of randomized controlled trials.docx by Longyi Zhang (11120151)

“…The LB group also exhibited lower cumulative morphine-equivalent opioid consumption within 72 h after surgery, a reduced incidence of PONV, and significantly higher patient satisfaction scores.</p>Conclusion<p>The use of LB was associated with improved QoR scores within 72 h after surgery, a reduced incidence of PONV, and decreased opioid consumption. …”

Table 1_Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024.docx by Miao Liu (148274)

“…BP co-detection rates with specific pathogens—human rhinovirus, adenovirus, Haemophilus influenzae, Staphylococcus aureus, and Mycoplasma pneumoniae significantly increased (all P_trend < 0.05), whereas parainfluenza virus co-infections decreased (P_trend < 0.05). …”

Data Sheet 1_Global, regional and national mortality burden of laryngeal cancer attributable to occupational exposure to sulfuric acid and asbestos: 1990–2021 and projections to 20... by Xin Gong (592328)

“…Disease burden varies significantly across SDI regions, suggesting that preventive measures should be tailored to specific SDI levels.…”