Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…<b>19c</b> markedly reduced fibrotic deposition, with a decrease in fibrosis stage and area in the CCl₄-induced liver fibrosis mouse model. …”

Antibodies used in this study. by Kevin J. Kokesh (19859571)

“…Western blot and densitometric analysis showed a significant increase in cathepsin B protein expression in <i>M</i>. …”

Time and flowrate used for proteomics. by Kevin J. Kokesh (19859571)

“…Western blot and densitometric analysis showed a significant increase in cathepsin B protein expression in <i>M</i>. …”

S1 Graphical abstract - by Kevin J. Kokesh (19859571)

“…Western blot and densitometric analysis showed a significant increase in cathepsin B protein expression in <i>M</i>. …”

Table 1_Metformin for neurocognitive dysfunction in schizophrenia: a systematic review.docx by Zhen-Juan Qin (16712376)

“…Two RCTs (50%) evaluated metformin's effects on total psychopathology and found no significant differences between groups. Adverse events were reported in two RCTs, with inconsistent findings on decreased appetite and diarrhea. …”

Anthropogenic soil acidification severely imperils microbial diversity and functionality: A global synthesis by d xz (16960341)

“…Anthropogenic soil acidification caused by nitrogen and acid addition significantly decreases microbial diversity, biomass, and functionality; in stark contrast, natural pH gradients exert only minimal effects on these microbial traits. …”

Minimal data set. by Daan P. van den Brink (9900073)

“…Plasma has been suggested as an alternative resuscitation fluid but it is unclear whether previously observed benefits were due to the type of fluid, or due to less volume required to restore tissue perfusion. We hypothesized that resuscitation with plasma reduces endothelial injury, inflammation, and organ injury compared to similar and higher volumes of crystalloids in a rat pneumosepsis model.…”

Image 5_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Image 2_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Table 1_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.docx by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Image 3_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Image 4_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Image 1_Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis.tif by Zhiyi Wang (328693)

“…</p>Results<p>NA and D2T patients demonstrated marked elevations in fecal pro-inflammatory cytokines compared to RE and HC groups, including IL-6, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), IL-1 beta (IL-1β), Interferon-gamma (INF-γ), IL-23, Tumor Necrosis Factor-Alpha (TNF-α), IL-21, IL-17A/F, and IL-22. Fecal zonulin and plasma HIF-2α were significantly elevated in both NA and D2T groups, whereas fecal D-lactate showed a pronounced decrease in the NA and D2T groups. …”

Data Sheet 1_Remarkable tumor response to Iruplinalkib in a 14-year-old girl with ALK-positive advanced metastatic non–small-cell lung cancer: a case report.pdf by Jiahao Wang (4710915)

“…We report a rare case of a 14-year-old girl, whose father and grandfather both had lung cancer, diagnosed with advanced, multi-site metastatic ALK-positive NSCLC. …”

Repetitive stress induces a reduction in sound-evoked activity that develops as the stressor becomes chronic. by Ghattas Bisharat (20706928)

“…(b) Change in activity across sessions per tracked cell in response to 40, 60, and 70 dB white noise. We found a negative slope in most cells especially for mid-intensities, indicating a decrease in activity as the stress becomes chronic (<i>t</i> test for 40 dB <i>p</i> = 0.36, for 60 dB <i>p</i> = 9.3 × 10⁻¹², and for 70 dB <i>p</i> = 0.00750). …”

Data Sheet 1_Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a... by Maximiliano Gabriel Castro (22179490)

“…Integrating the NA and mBCT into IPC protocols led to a decrease in CPB rectal carriage prevalence in general wards, underscoring their diagnostic, epidemiological and thus IPC benefits.…”

Multiomics Identified the Nutritional Improvement in LAB-Fermented Goat Milk by Liyan Ge (13017372)

“…Using multiomics, we found that FGM has reduced microbial diversity, with increased <i>Streptococcus</i> and <i>Lactobacillus</i> and decreased <i>Klebsiella</i>. …”

Supplementary Material for: The power of a good word: Enhancing the efficacy of analgesics in clinical settings by Treister R. (19801920)

“…In study 2, in the last two timepoints of assessment, participants in the EC arm also consumed fewer doses of opioids than participants in the RC arm (p<0.001). No significant differences were found in vital signs. Conclusions: We provide ecological evidence that positive information about treatment significantly decreases pain and opioid consumption during routine clinical care. …”

<b>IMPACT OF MULTIVITAMINS AND PROCESSED MEAT ON AGING: A MACHINE LEARNING APPROACH</b> by Mohcene M. (20142864)

“…</p><p dir="ltr">This suggests that processed meat consumption is linked to an increased aging gap, whereas vitamin intake is associated with a decreased aging gap, reflecting a positive effect on aging. …”

Table 1_Effects of a community pharmacy-based structured medication review on drug-related problems in all-comers with polypharmacy: a randomized, controlled, double-blind, paralle... by Thorsten Bischof (19848696)

“…Therapy adherence- and health literacy-related DRPs decreased significantly by ~60% and ~64%, respectively. …”