Data Sheet 1_Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease.pdf by Faruk Hossen (20275670)

“…Specifically, we found significant decreases in insulin receptor-α (IR-α) and insulin receptor-β (IR-β) expression, along with increased levels of phospho-insulin receptor substrate 1 at Ser307 [p-IRS-1 (Ser307)] and decreased levels of p-IRS-1 (Tyr895), compared to wild-type (WT) mice. …”

Bad Estimation, Good Prediction: The Lasso in Dense Regimes by Andrea Bratsberg (22392452)

“…We prove that the prediction bound under this model in fact decreases with increasing number of predictors, and confirm this through simulation examples. …”

Image 1_L1, a 3,3′-diindolylmethane-derivative, induced ER stress-mediated apoptosis and suppressed growth through the FLI1/AKT pathway in erythroleukemia HEL cells.tif by Yi Kuang (1873354)

“…Moreover, FLI1 is a crucial target for mediating cell differentiation, apoptosis, inflammation and displays abnormal expression in HEL cells. Here, we showed that the protein expression levels of FLI1 and AKT/p-AKT decreased with L1 treatment and that the RNA expressions of their downstream genes GATA1, TFRC, GYPA, CDKN1A and CDKN1B were also regulated by L1.…”

Image 2_L1, a 3,3′-diindolylmethane-derivative, induced ER stress-mediated apoptosis and suppressed growth through the FLI1/AKT pathway in erythroleukemia HEL cells.tif by Yi Kuang (1873354)

“…Moreover, FLI1 is a crucial target for mediating cell differentiation, apoptosis, inflammation and displays abnormal expression in HEL cells. Here, we showed that the protein expression levels of FLI1 and AKT/p-AKT decreased with L1 treatment and that the RNA expressions of their downstream genes GATA1, TFRC, GYPA, CDKN1A and CDKN1B were also regulated by L1.…”

Additional file 6 of NSDHL contributes to breast cancer stem-like cell maintenance and tumor-initiating capacity through TGF-β/Smad signaling pathway in MCF-7 tumor spheroid by So-Hyun Yoon (5353250)

“…Supplementary Material 6: Figure S6. A-83-01 (50 µM) decreased the phosphorylation of both SMAD2 and SMAD3 but did not show significant toxicity in MCF-7-spheroids. …”

Glial 5-HT_2a receptors are necessary and rate limiting for experience-dependent synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…All the individual data points are shown with mean ± SEM. Significance is indicated as <i>p</i> < 0.0001 (****) and <i>p</i> > 0.05 (not significant, ns). …”

Cell surface sialic acid is not required for SARS-CoV-2 spike glycoprotein binding. by Kimberley C. Siwak (20378620)

“…Statistical significance was assessed by two-way ANOVA (****p<0.0001; ns, not significant).…”

Table 1_Perioperative neurocognitive disorder in colorectal cancer surgery: a systematic review of incidence, mechanisms, and interventions.doc by Xiujin Huang (22637270)

“…Key risk factors included advanced age (mean 63–76 years), ASA status II–III, and open surgery. …”

Supplementary file 1_Modulatory effects of transcranial direct current stimulation on sensory gating in Fibromyalgia Syndrome.docx by Juan L. Terrasa (5506691)

“…</p>Methods<p>Thirty-nine female Fibromyalgia Syndrome patients (43–71 years, mean 55.56 ± 7.85) participated in the study and were randomly assigned to the active transcranial direct current stimulation (n = 17) or non-electrical stimulation (sham; n = 22). …”

Table 1_Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.docx by Juan Liu (6492)

“…</p>Methods<p>In this study, we evaluated the synergism of tigecycline combining with other antibiotics as a means of overcoming the tet(X)-mediated resistance in Acinetobacter spp. …”

Data Sheet 1_Patient-centered modeling of the breast biopsy experience.pdf by Isabel Nieto-Alvarez (22425466)

“…Centering each individual's procedure time at her first local anesthesia (LA) revealed a significant (βt2p = 5.43e⁻⁰⁶) temporal pattern in anxiety, which increased until LA and decreased afterwards. …”

Table 2_Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy.csv by N. J. L. Smeets (21188726)

“…Additionally, we investigated metabolic profiles in CHD patients and healthy controls.…”

Table 1_Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy.csv by N. J. L. Smeets (21188726)

“…Additionally, we investigated metabolic profiles in CHD patients and healthy controls.…”

Data Sheet 1_Coordinated development of ecosystem services and human well-being is increasing in the Yellow River Basin, though some regions lag behind.docx by Menghao Yang (18527892)

“…Finally, we predicted the development trajectory of the coupled system in the next 20 years. …”

CDCP1 regulates CDA and hENT1 expression through c-Src/PKCδ signaling pathway. by Kun-Lin Hsieh (11401919)

“…Data are presented as mean ± SD with statistical significance indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001.…”

Table 1_Assessment the relationship between health anxiety and iranian nurses’ quality of life: a cross-sectional study.docx by Zahra Amoozadeh (20944724)

“…</p>Conclusion<p>This study showed that there is a significant relationship between health anxiety and different dimensions of quality of life, so that the quality of life of nurses decreases with the increase of health anxiety.…”

Other differentially-accumulated metabolites in <i>P</i>. <i>fijiensis</i> exposed to thiabendazole. by María Gabriela Maridueña-Zavala (3377081)

“…Values represent the means and standard errors of 5 replicates. Different letters represent significant differences (p < 0.05).…”

Impact of COVID-19 on early intervention referrals (Zellner et al., 2025) by Matthew A. Zellner (12043395)

“…</p><p dir="ltr"><b>Results: </b>Overall, we found large decreases in service provision rates for the first 2 timepoints; however, by September 2021, rates had moved closer to expected prepandemic levels. …”

Table 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.xlsx by Sergey A. Gorbarenko (13696381)

“…Based on the constructed stack, we identified and categorized 15 notable Holocene centennial cooling events (HCCEs) in the NH (period with temperature decreases). …”

Data Sheet 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.docx by Sergey A. Gorbarenko (13696381)

“…Based on the constructed stack, we identified and categorized 15 notable Holocene centennial cooling events (HCCEs) in the NH (period with temperature decreases). …”