Image 5_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…The unexplored potential of chemical checkpoint inhibitors in rejuvenating immune responses prompted our investigation.</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Table 1_Magnesium application partially reversed the negative effects of mulching on rhizosphere nitrogen cycling in a Phyllostachys praecox forest.xlsx by Hong Zhao (325)

“…To address this, our study investigated rhizosphere nitrogen cycling in Lei-bamboo across a short-term degradation cycle. We found that mulching enhanced the abundance of 16S-rRNA and nitrogen-cycling functional genes. …”

Image 3_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…The unexplored potential of chemical checkpoint inhibitors in rejuvenating immune responses prompted our investigation.</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Table 1_Expansion of CD57+ CD8 T cells in common variable immunodeficiency with hepatopathy and CMV infection.pdf by Patrick Bez (13168041)

“…</p>Results<p>The expansion of CD57⁺ CD8 T cells was part of the previously described immune alteration, including altered CD4/CD8 ratio and a decrease in naïve CD4 T cells. The loss of significant association with increasing age might corroborate the suggestion of premature immunosenescence in CVID. …”

Image 9_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…The unexplored potential of chemical checkpoint inhibitors in rejuvenating immune responses prompted our investigation.</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Table 1_Working like a mule? The physiological toll of heavy loads on mules.docx by Tamara Tadich (17244898)

“…Enzymatic activities of γ-glutamyltransferase (GGT), lactate dehydrogenase (LDH), and alkaline phosphatase (SAP/ALP) also increased with heavier loads, suggesting greater muscular effort and mild tissue stress. Conversely, glutathione peroxidase (GPx) activity decreased as load increased, implying increased oxidative demand. …”

3D modelling of the impact of stellar activity on tidally-locked terrestrial exoplanets: atmospheric composition and habitability (dataset) by R Ridgway (9137141)

“…We find that coronal mass ejections abiotically generate significant levels of potential bio-signatures such as N2O. …”

Supplementary file 1_Influence of circadian rhythm on the determination of the IMMune age indeX (IMMAX).docx by Sina Trebing (22578458)

“…</p>Results<p>While individual immune cell ratios showed changes during the day, we determined no significant variability of the IMMAX score between the measurements. …”

Flowchart of the study. by Ramazan Cevik (19959160)

“…After the intervention, all groups showed increased ROM and decreased VAS and NDI scores (p<0.001). The Mulligan group exhibited significantly greater improvement in VAS, ROM, and NDI compared to other groups (p<0.001). …”

Sex-specific responses of mosquitoes to <i>Bti</i> pesticide and odonate predators by Jaclyn Everly (22623200)

“…Rather than mitigating the effects of Bti, the interaction of predators and Bti synergistically decreased adult male size. We discuss the roles of competition, phenotypic plasticity, selective predation, and sublethal Bti exposure potentially contributing to these results, emphasizing the complex interactions among sources of extrinsic and intrinsic mortality and their divergent effects across taxa, sexes, and environments that have important implications for both theoretical and applied ecology.…”

Image 1_Immunomodulatory and anti-inflammatory effects of agave fructans in atopic dermatitis: gut microbiota and short-chain fatty acid implication.tif by Marcela Rios-Carlos (22759823)

“…After AFs treatment at 0.1 g/kg, serum IgE levels were normalized to those of control animals. All AFs significantly decreased dermal mast cell and eosinophil counts, as well as epidermal thickening, with greater efficacy observed at lower doses. …”

Data Sheet 1_Temperature extremes across elevation gradients: evidence from two German mountain observatories.pdf by Monica Ionita (6486275)

“…., 1781–2024) and Zugspitze (2,956 m a.s.l., 1901–2024). We find a pronounced warming at both sites, characterized by significant acceleration in recent decades. …”

Image 2_Immunomodulatory and anti-inflammatory effects of agave fructans in atopic dermatitis: gut microbiota and short-chain fatty acid implication.tif by Marcela Rios-Carlos (22759823)

“…After AFs treatment at 0.1 g/kg, serum IgE levels were normalized to those of control animals. All AFs significantly decreased dermal mast cell and eosinophil counts, as well as epidermal thickening, with greater efficacy observed at lower doses. …”

Image 4_Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study.tif by Yanwen Xu (663813)

“…We aimed to explore the prognostic and predictive value of serum neuritin in ICH.…”

Image 6_Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study.tif by Yanwen Xu (663813)

“…We aimed to explore the prognostic and predictive value of serum neuritin in ICH.…”

Image1_Predicting acute lung injury in infants with congenital heart disease after cardiopulmonary bypass by gut microbiota.jpeg by Lan Jiang (57811)

“…The microbiota diversity was low in the CPB-ALI group with high pathogen abundance and significant decrease in Bacteroides, while the opposite was observed in the CPB-NALI group. …”

Image_1_Exploring the association between phytopharmaceutical use and antibiotic prescriptions in upper respiratory infections: results from a German cohort study evaluating the im... by Anna-Jasmin Wetzel (17837840)

“…</p>Conclusion<p>Prescriptions of phytopharmaceuticals were significantly associated with a decrease antibiotic prescriptions among GPs, especially when combined with naturopathy qualifications. …”

Image 3_Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study.tif by Yanwen Xu (663813)

“…We aimed to explore the prognostic and predictive value of serum neuritin in ICH.…”

Image 7_Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study.tiff by Yanwen Xu (663813)

“…We aimed to explore the prognostic and predictive value of serum neuritin in ICH.…”

Table 5_Active ingredients isolated from Periplaneta americana L. inhibit the inflammation of the colonic mucosa and regulate the gut microbiota in DSS-induced ulcerative colitis i... by Yanhuan Wang (12037016)

“…Furthermore, PA treatment attenuated intestinal dysbiosis in UC mice, characterized by an increase in beneficial bacteria (e.g., Psychrobacter) and a decrease in taxa like Actinobacteriota.</p>Conclusion<p>These findings collectively indicate that the aqueous extract of Periplaneta americana L. and its fractions possess significant therapeutic potential for UC treatment, with the unfractionated extract showing the most pronounced benefits via modulating inflammation, restoring barrier function, and rebalancing gut microbiota.…”