Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Combination of intraperitoneal and intratumoral administration of vitamin D3 is more effective in reducing the EAC tumor volume compared to just i.p. administration: by Vidya G. Bettada (22208808)

“…Administration of cisplatin (2.5 mg/Kg) and vitamin D3 (125 µg/Kg) significantly decreased the vessel density (CD31) compared to the tumor control group.…”

Primary data. by Andrey V. Cybulsky (4007012)

“…However, there was no significant correlation between the degree of hyperglycemia and albuminuria, and even iPLA₂γ KO mice with greatest hyperglycemia did not develop significant albuminuria. …”

Mortality dataset used in analysis. by Samuel Sendagala (21417164)

“…<div><p>Background</p><p>Uganda reported a significant reduction in the mortality rate of children under 5 years of age, from 146/1,000 live births in 2000–42/1,000 live births in 2021. …”

Influence of DCR on the distinction between instances in YouTube-VIS 2019 dataset. by Farnoosh Arefi (19812520)

Speech material modulation spectrum and behavioral speech recognition task results. by Elena Bolt (20396190)

Minimal dataset. by Jennifer M. Kwan (3350321)

“…Secondary outcomes included all-cause mortality and the individual components of ACE. We additionally conducted an imaging substudy examining imaging characteristics from echocardiography (echo) and cardiac magnetic resonance (CMR) imaging.…”

The four phases of AcMNPV infection cycle and the design of dual reporter baculovirus (DRBac). by Enrique Paz-Cortés (20988196)

Literature comparison. by Saravanan Manoharan (21273304)

“…To reduce labeling effort, we apply a Query by Committee-based active learning technique, significantly decreasing the required labeling effort by one-sixth. …”

Flow chart of proposed system. by Saravanan Manoharan (21273304)

“…To reduce labeling effort, we apply a Query by Committee-based active learning technique, significantly decreasing the required labeling effort by one-sixth. …”

Literature review. by Saravanan Manoharan (21273304)

“…To reduce labeling effort, we apply a Query by Committee-based active learning technique, significantly decreasing the required labeling effort by one-sixth. …”

IMU data and video synchronization. by Saravanan Manoharan (21273304)

“…To reduce labeling effort, we apply a Query by Committee-based active learning technique, significantly decreasing the required labeling effort by one-sixth. …”

Confusion matrix-punch classification. by Saravanan Manoharan (21273304)

“…To reduce labeling effort, we apply a Query by Committee-based active learning technique, significantly decreasing the required labeling effort by one-sixth. …”

KO of iPLA₂γ attenuates development of albuminuria in STZ-induced diabetic nephropathy. by Andrey V. Cybulsky (4007012)

Demographics of the enrolled patients. by Yuka Kasai (21354922)

“…The success rate in the seated position without the eye drop aid was 71.6%, and this rate decreased with increasing age; with the eye drop aid, the success rate improved significantly to 97.8%. …”

Overhead view of the eye drop aid. by Yuka Kasai (21354922)

“…The success rate in the seated position without the eye drop aid was 71.6%, and this rate decreased with increasing age; with the eye drop aid, the success rate improved significantly to 97.8%. …”

Data. by Michael C. Payne (2664379)

“…Using a generalized estimating equation model that accounted for age, sex, bednet use, and sentinel site, we found no significant difference in the effectiveness of the two treatment approaches (p = 0.845 for Mf and p = 0.332 for CFA). …”

Comparison of absolute and relative errors. by Lahoucine Tadoummant (21647670)

“…A significant reduction in both error types is observed, with the relative error |<i>X</i>_<i>r</i>| decreasing from approximately 10⁻¹ to 10⁻⁸. …”