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we decrease » _ decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
less decrease » mean decrease (Expand Search), teer decrease (Expand Search), levels decreased (Expand Search)
we decrease » _ decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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Quantitative Proteomics Unveils the Synergistic Effects of Combination Drugs on Cytoskeleton Composition and Autophagy-Mediated Cell Death in Neuroblastoma
Published 2025“…The mRNA expression levels of several genes predicted by LINCS also decreased. To comprehensively understand the mechanism behind superior efficacy of the combination therapy compared to monotherapy, we performed quantitative proteomics with tandem mass tag labeling and identified 3416 proteins from 20,623 peptides. …”
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The spheroid assay is used to assess long-term effects of therapy on tumor cell by culturing the tumor cells in a micro-mass, which is a 3D tumor mass used as a surrogate for in vi...
Published 2025“…<p>(A) MCF7 tumor cell micro-mass cultures (purple staining) treated with 0-, 1-, 2-, 2.5-, 5-, and 10-mM N-allyl noroxymorphone doses, after 336-hours, produced a significant decrease of 41.9% and 68.1% in micro-mass areas for the 5- and 10-mM N-allyl noroxymorphone concentrations, respectively (* = p < 0.014 and **** = p < 0.0001). …”
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BrdU assay in control siRNA (blue bars) and in PAX6 knockdown (red bars) limbal epithelial cells (LECs) without and after 1µM or 5µM RA incubation for 48 hours.
Published 2025“…<p>Two-way ANOVA, followed by Dunnett’s test was used. Significant p values (<0.05) are highlighted. BrdU assay shows a significantly lower proliferation rate in the PAX6 siRNA knockdown group than in control siRNA group (p < 0.001). 5µM RA treatment significantly decreased proliferation rate in controls (p = 0.025). …”
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Primers used for RT-qPCR.
Published 2025“…We constructed a protein-protein interaction (PPI) network and performed GO and KEGG enrichment analyses, whcih revealed key signaling pathways involved in PI3K/Akt, inflammation, and autophagy. …”
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Data Sheet 1_Previous COVID-19 infection significantly reduces elastase levels in newly diagnosed pulmonary tuberculosis patients.pdf
Published 2025“…Introduction<p>Tuberculosis (TB) is considered a risk factor for severe COVID-19 disease and the quality of life of patients co-infected with COVID-19 and TB is significantly impacted due to the nature of these diseases. …”
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Overview of the parameters used in the model.
Published 2024“…<div><p>Background</p><p>Chikungunya virus (CHIKV) outbreaks, driven by the expanding habitat of the <i>Aedes albopictus</i> mosquito and global climate change, pose a significant threat to public health. Our study evaluates the effectiveness of emergency vaccination using a dynamic disease transmission model for a potential large-scale outbreak in Rome, Italy.…”