Chemogenetic inhibition of Calcrl⁺ neurons attenuates chronic itch in multiple chronic itch models. by Huifeng Jiao (11537806)

“…<p><b>(A-C)</b> Allergic Contact Dermatitis (ACD) Model (n = 7 mice for each group): Experimental timeline showing intraspinal viral injection, ACD model induction, and behavioral testing phases <b>(A)</b>; Quantification of mechanical itch responses revealed significant CNO-mediated suppression in hM4Di mice, with no effect in vehicle-treated controls <b>(B)</b>; Spontaneous scratching frequency decreased following CNO administration <b>(C)</b>. …”

Ambient Air Pollutant Dynamics (2010–2025) and the Exceptional Winter 2016–17 Pollution Episode: Implications for a Uranium/Arsenic Exposure Event by Thomas Clemens Carmine (19756929)

“…PM₁₀ also shows a general decrease. CO appears relatively more stable.…”

Table 2_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.xlsx by Jing Wang (6206297)

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.…”

Image 1_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.tif by Jing Wang (6206297)

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.…”

Image 2_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.tif by Jing Wang (6206297)

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.…”

Table 1_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.docx by Jing Wang (6206297)

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.…”

Genes in the top 10 up- and down-regulated. by Chaoyun Yang (11523358)

“…The results of transcriptome sequencing demonstrated that the overexpression of the HADHB gene markedly altered the transcriptional profile of preadipocytes, with 170 genes exhibiting a significant increase in expression and 113 genes displaying a decrease. …”

Differential analysis between OEG and CG groups. by Chaoyun Yang (11523358)

“…The results of transcriptome sequencing demonstrated that the overexpression of the HADHB gene markedly altered the transcriptional profile of preadipocytes, with 170 genes exhibiting a significant increase in expression and 113 genes displaying a decrease. …”

Overview of Sequencing Results. by Chaoyun Yang (11523358)

“…The results of transcriptome sequencing demonstrated that the overexpression of the HADHB gene markedly altered the transcriptional profile of preadipocytes, with 170 genes exhibiting a significant increase in expression and 113 genes displaying a decrease. …”

PCA plot of OEG group and CG group. by Chaoyun Yang (11523358)

“…The results of transcriptome sequencing demonstrated that the overexpression of the HADHB gene markedly altered the transcriptional profile of preadipocytes, with 170 genes exhibiting a significant increase in expression and 113 genes displaying a decrease. …”

siRNA sequences designed for this study. by Chaoyun Yang (11523358)

“…The results of transcriptome sequencing demonstrated that the overexpression of the HADHB gene markedly altered the transcriptional profile of preadipocytes, with 170 genes exhibiting a significant increase in expression and 113 genes displaying a decrease. …”

Statistics of reads aligned to gene structure. by Chaoyun Yang (11523358)

“…The results of transcriptome sequencing demonstrated that the overexpression of the HADHB gene markedly altered the transcriptional profile of preadipocytes, with 170 genes exhibiting a significant increase in expression and 113 genes displaying a decrease. …”

Protocols for real-time quantitative PCR. by Chaoyun Yang (11523358)

“…The results of transcriptome sequencing demonstrated that the overexpression of the HADHB gene markedly altered the transcriptional profile of preadipocytes, with 170 genes exhibiting a significant increase in expression and 113 genes displaying a decrease. …”

The Original gel map protein immunoblotting. by Chaoyun Yang (11523358)

“…The results of transcriptome sequencing demonstrated that the overexpression of the HADHB gene markedly altered the transcriptional profile of preadipocytes, with 170 genes exhibiting a significant increase in expression and 113 genes displaying a decrease. …”

YFV-Asibi cap0 grows slower and to reduced viral titers in secondary tissues after intrathoracic injection. by Anja vom Hemdt (19787189)

Supplementary Material for: A comparative cross-sectional study of hair density, hair shaft diameter of different severities of anterior scalp marginal traction alopecia in women. by Anaba E.L. (16407435)

“…With increasing severity of AMTA, there was a significant decrease in HD: Grade 1 had HD of 227.56/cm2 compared to 131.22/cm2 in grade 4 at the intertemporal area, p<0.001. …”

Data Sheet 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.xlsx by Demos Kynigopoulos (12420457)

“…Increasing evidence implicates systemic metabolic dysregulation in AD pathogenesis, yet it remains unclear whether modulation of peripheral lipid and glucose metabolism can alter disease progression.</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

Data Sheet 1_α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach.docx by Aimin Cai (6190532)

“…</p>Methods<p>In this study, we employed a nuclear magnetic resonance-based metabolomic approach to investigate the therapeutic effects of α-MT in a db/db mouse model of DN and explore the underlying molecular mechanisms.…”

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx by Demos Kynigopoulos (12420457)

“…Increasing evidence implicates systemic metabolic dysregulation in AD pathogenesis, yet it remains unclear whether modulation of peripheral lipid and glucose metabolism can alter disease progression.</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

Table 2_Integrated effects of Kampo treatment on gastrointestinal symptoms and stress in patients with functional dyspepsia: a preliminary prospective observational study.docx by Lian Liang (11550511)

“…Additionally, there was a significant decrease in negative mood components (anger and depression) and total mood disturbance. …”