Pediatric CPP with Praat and ADSV (Joshi et al., 2025) by Ashwini Joshi (21594817)

“…However, “normative” age-based expectations should be approached with caution since the general effect of age may be superseded by specific changes in <i>F</i>0 where a lowering of <i>F</i>0 is significantly associated with increases in CPP.…”

Sequence composition analysis identifies distinct A + U and C + G base frequencies within subregions of mRNA transcripts – with effects on protein coding potential. by Benjamin S. Pickard (21276556)

Frequency trajectories of iSNVs that fluctuated (Top) and their positions on the genome (Bottom) (patients A-I). by Lele Zhao (532080)

Addressing Imbalanced Classification Problems in Drug Discovery and Development Using Random Forest, Support Vector Machine, AutoGluon-Tabular, and H2O AutoML by Ayush Garg (21090944)

“…The important findings of our studies are as follows: (i) there is no effect of threshold optimization on ranking metrics such as AUC and AUPR, but AUC and AUPR get affected by class-weighting and SMOTTomek; (ii) for ML methods RF and SVM, significant percentage improvement up to 375, 33.33, and 450 over all the data sets can be achieved, respectively, for F1 score, MCC, and balanced accuracy, which are suitable for performance evaluation of imbalanced data sets; (iii) for AutoML libraries AutoGluon-Tabular and H2O AutoML, significant percentage improvement up to 383.33, 37.25, and 533.33 over all the data sets can be achieved, respectively, for F1 score, MCC, and balanced accuracy; (iv) the general pattern of percentage improvement in balanced accuracy is that the percentage improvement increases when the class ratio is systematically decreased from 0.5 to 0.1; in the case of F1 score and MCC, maximum improvement is achieved at the class ratio of 0.3; (v) for both ML and AutoML with balancing, it is observed that any individual class-balancing technique does not outperform all other methods on a significantly higher number of data sets based on F1 score; (vi) the three external balancing techniques combined outperformed the internal balancing methods of the ML and AutoML; (vii) AutoML tools perform as good as the ML models and in some cases perform even better for handling imbalanced classification when applied with imbalance handling techniques. …”

Serum metabolomic response to aging. by Gwangho Yoon (5771678)

“…<b>(B)</b> Metabolites that decreased with aging. Statistical significance is indicated in the heatmap with asterisks. …”

Various stereological parameters characterizing lung parenchyma and AEII before, during and after alveolarization as well as in adults. by Julia Hüttmann (22656283)

“…PLoS One. 2024 Mar 14;19(3):e029. b) The total number of alveolar epithelial cells type II (N(AEII, lung)) shows a significant increase after the end of bulk alveolarization and in adults compared to 3 days old rats. c) During alveolarization the number of AEII per mm² alveolar surface (N(AEII, lung)/S(alveoli, lung)) decreases continuously reaching the significant lowest values in adults. d) The number of AEII related to lung volume decreases continuously during alveolarization. …”

Effects of Ni²⁺ on mitochondrial (A), glycolytic (B), and total (C) ATP production rates in BMDM. by Jesse Corbin (21736578)

“…A double dagger (‡) indicates a significant decrease of mitochondrial ATP production rates (slope = −0.79 ± 0.21, <i>R</i>^<i>2</i> = 0.40, <i>F</i>(1, 22)=15.0, <i>p </i>< 0.001) from 0 to 72 ppm Ni²⁺. …”

Δ<i>guaA,</i> a mutant that lacks a cytochrome P450 monooxygenase, does not grow on guaiacol. by Claudia Castro (585495)

“…</i> Wildtype (solid black line) showed growth (OD_{600 nm}) and guaiacol degradation (blue line) beginning 24 hours post-incubation. Meanwhile, Δ<i><i>guaA</i></i> (dashed black line) never demonstrated an increase in OD_{600 nm} or significant guaiacol decrease (<i><i>n</i> </i>= 12)<i>.…”

Supplementary Table 1–9. by Yu Wang (12152)

“…To gain further insight, expression quantitative trait loci (eQTL) data were used to investigate the significant drug targets for lipid-lowering.</p><p>Results</p><p>Increasing ApoA-1 levels was associated with a diminished risk of sepsis (under 75) (OR 0.927, 95% CI 0.861–0.999; p = 0.047). …”

STROBE-MR checklist. by Yu Wang (12152)

“…To gain further insight, expression quantitative trait loci (eQTL) data were used to investigate the significant drug targets for lipid-lowering.</p><p>Results</p><p>Increasing ApoA-1 levels was associated with a diminished risk of sepsis (under 75) (OR 0.927, 95% CI 0.861–0.999; p = 0.047). …”

Instrumental Variables details of lipids. by Yu Wang (12152)

“…To gain further insight, expression quantitative trait loci (eQTL) data were used to investigate the significant drug targets for lipid-lowering.</p><p>Results</p><p>Increasing ApoA-1 levels was associated with a diminished risk of sepsis (under 75) (OR 0.927, 95% CI 0.861–0.999; p = 0.047). …”

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

“…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …”

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

“…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …”

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

“…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …”

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

“…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …”

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

“…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …”

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

“…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …”

Hydrogen bond interactions between Capivasertib (red) and the AKT2 protein (blue) as predicted by molecular docking analyses. by Sadia Afrin Runa (22504971)

Hydrogen bond interactions between Ipatasertib (red) and the AKT2 protein (blue) as predicted by molecular docking analyses. by Sadia Afrin Runa (22504971)

Hydrogen bond interactions between Akt1/Akt2-IN-1 (red) and the AKT2 protein (blue) as predicted by molecular docking analyses. by Sadia Afrin Runa (22504971)