Multi-omics revealed GOT1/ALDH3A1 pathway attenuated head and neck squamous cell carcinoma and increased cisplatin sensitivity through ROS induced by mitochondrial dysfunction by Zhihui Liu (95891)

“…Given that mitochondria are the primary source of reactive oxygen species (ROS), we assessed cellular ROS and mitochondrial superoxide levels by flow cytometry and found a significant increase. GOT1 knockdown increased the sensitivity of cells to cisplatin and decreased the volume of tumors in vivo. …”

Study sample. by Nipaporn Butsing (19470003)

“…One increased National Institute of Health Stroke Scale (NIHSS) score decreased adjusted BI scores by 3.6.</p><p>Conclusion</p><p>The time after discharge, gender, stroke subtype, and stroke severity are significant factors affecting functional outcomes after a stroke. …”

Spatial econometric model estimation results. by Zijie Li (776536)

“…In the stage of high-quality development (2012 present), the contribution rate of technological factors continued to rise and become the dominant factor, while the contribution rate of land factors has decreased to a lower level. (2) Regarding spatial characteristics, the spatial econometric model reveals significant spatial agglomeration characteristics of capital and labor, and land factors positively affect local and neighboring economic growth. …”

Description of various production factors. by Zijie Li (776536)

“…In the stage of high-quality development (2012 present), the contribution rate of technological factors continued to rise and become the dominant factor, while the contribution rate of land factors has decreased to a lower level. (2) Regarding spatial characteristics, the spatial econometric model reveals significant spatial agglomeration characteristics of capital and labor, and land factors positively affect local and neighboring economic growth. …”

Regression coefficients of production function. by Zijie Li (776536)

“…In the stage of high-quality development (2012 present), the contribution rate of technological factors continued to rise and become the dominant factor, while the contribution rate of land factors has decreased to a lower level. (2) Regarding spatial characteristics, the spatial econometric model reveals significant spatial agglomeration characteristics of capital and labor, and land factors positively affect local and neighboring economic growth. …”

Production function regression ridge trace. by Zijie Li (776536)

“…In the stage of high-quality development (2012 present), the contribution rate of technological factors continued to rise and become the dominant factor, while the contribution rate of land factors has decreased to a lower level. (2) Regarding spatial characteristics, the spatial econometric model reveals significant spatial agglomeration characteristics of capital and labor, and land factors positively affect local and neighboring economic growth. …”

Model test results. by Zijie Li (776536)

“…In the stage of high-quality development (2012 present), the contribution rate of technological factors continued to rise and become the dominant factor, while the contribution rate of land factors has decreased to a lower level. (2) Regarding spatial characteristics, the spatial econometric model reveals significant spatial agglomeration characteristics of capital and labor, and land factors positively affect local and neighboring economic growth. …”

Immuno-infiltration analysis. by Wan-Jing Zhen (20427813)

Multiple linear regression analysis results. by Muxi Chen (9294270)

“…Cohesiveness varied without a clear linear trend, showing significant changes at specific IDDSI levels for meats, grains, and tubers (<i>p</i>≤0.05). …”

Relationships between hardness and IDDSI levels. by Muxi Chen (9294270)

“…Cohesiveness varied without a clear linear trend, showing significant changes at specific IDDSI levels for meats, grains, and tubers (<i>p</i>≤0.05). …”

(Related to Fig 1): LPN promote evening sleep via AstC under high temperature condition. by Xin Yuan (174619)

“…(C, D) LPN activation via the thermogenetic dTrpA1 channel (<i>LPN-spGal4>Uas-dTrpA1</i>) significantly decreases daily locomotion compared to baseline (black bar). …”

Primers used for PCR and qRTPCR. by Huan W. Yang (19746645)

“…There were no significant changes in NF-κB signalling between vaccine and Dkp23 infection in PK-15 cells, except for moderate levels of differences in NF-κB target genes expression which might be a reflection of differences in intracellular bacterial load. …”

Western blots used for Fig 4C. by Huan W. Yang (19746645)

“…There were no significant changes in NF-κB signalling between vaccine and Dkp23 infection in PK-15 cells, except for moderate levels of differences in NF-κB target genes expression which might be a reflection of differences in intracellular bacterial load. …”

GSVA results. by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

Differential expressed genes. by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

S1 Raw image - by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

Venn plot. by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

Key module genes. by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

Univariate and multivariate Cox analysis. by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

S3 Fig - by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”