Supplementary Material for: Preliminary efficacy, tolerability, and safety analysis of Darolutamide for metastatic castration‑resistant prostate cancer: a single-center, open-label... حسب Yu J. (3610580)

"…The median time to PSA50 in the Darolutamide group was 1.5 months (95%CI 0.2619- 0.9545), significantly lower than that in the placebo group (3.0 months [95%CI 1.048- 3.818], p= 0.0259); The median time to PSA90 in the experimental group was 4 months (95%CI 0.3094- 1.437), 2 months shorter than that in the placebo group (6.0 months [95%CI 0.6961- 3.232]).With the median follow-up of 6 months, , the median decrease in serum PSA was -81.8% (range -60.4 to -99.9%) in the Darolutamide group and -69.4% (range -50.3 to -89.6%) in the placebo group. …"

NHR-49/80 mediated FEDUS via the peroxisomal activation. حسب Meiyu Ruan (19929335)

"…<b>(L)</b> A bar graph showing AWC neurons maturation of animals grew at various population densities. Lower population density significantly decreased palmitic acid-induced AWC maturation. …"

Data Sheet 1_PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma.docx حسب Qiyue Zhao (12721537)

"…Expression of these hub genes was further validated by RT-qPCR.</p>Results<p>We found that most of the PRGs were upregulated in ccRCC tumors with low mutation rates, and 18 PRGs exhibited a significant correlation with ccRCC patient survival. …"

Data Sheet 1_Systematic analysis of the burden of ischemic stroke attributable to high LDL-C from 1990 to 2021.pdf حسب Jiahao Tang (12360233)

"…However, the disease burden in high SDI countries remains significant, indicating potential for reduction. Predictions for the next 15 years suggest that while the global disease burden will decrease, there may be an increase among individuals under 55.…"

Image 4_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff حسب Mireille Ngokingha Tchouto (20812811)

"…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …"

Table 1_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.xlsx حسب Mireille Ngokingha Tchouto (20812811)

"…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …"

Image 2_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff حسب Mireille Ngokingha Tchouto (20812811)

"…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …"

Image 1_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff حسب Mireille Ngokingha Tchouto (20812811)

"…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …"

Data Sheet 1_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.docx حسب Mireille Ngokingha Tchouto (20812811)

"…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …"

Image 3_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff حسب Mireille Ngokingha Tchouto (20812811)

"…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …"

Table 1_Respiratory microbiome and metabolome features associate disease severity and the need for doxycycline treatment in children with macrolide-resistant Mycoplasma pneumoniae-... حسب Wei-Chao Liao (3574649)

"…We identified 15 discriminative amino-acid- and fatty-acid-related metabolites in two groups. …"

Image 5_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff حسب Mireille Ngokingha Tchouto (20812811)

"…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …"

Table 2_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.xlsx حسب Mireille Ngokingha Tchouto (20812811)

"…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …"

Data Sheet 1_Decadal changes in species composition of rare oak Quercus chungii forests with logging history.docx حسب Wenbin Li (92586)

"…We found that the communities undergone significant species replacement and reordering from 2013 to 2023, thus leading to high temporal β diversity. …"

Processed Data for “Projecting long-term excess risks of major infectious diseases associated with future extreme weather events in Thailand” حسب Esther Choo (22590272)

"…</p><p dir="ltr">Historically, extreme heat was associated with an increase in all infectious disease incidences except malaria and leptospirosis. We projected that dengue risk declines in most future climate change scenarios, except SSP245 where extreme heat drives a significant rise in Northern and Central Thailand from 2021–2060. …"

<b>Cannabinoid Receptor 2 Agonism Demonstrates Therapeutic </b><b>Potential in Experimental Models of Relevance to Diabetic Retinopathy</b> حسب Cayla D. Ontko (21434062)

"…<i>In vivo</i>, both intraocular and systemic HU-308 administration significantly decreased retinal leukostasis in cytokine-induced inflammation and STZ-induced diabetes. …"

Table 1_Associations between ultra-processed foods intake and preserved ratio impaired spirometry in U.S. adults.docx حسب Weiliang Kong (12573067)

"…Furthermore, higher UPFs (%Kcal) intake negatively affected lung function, with participants in the highest quartile showing a significant reduction in forced expiratory volume in 1 s (FEV1) of −45.5 mL (95% CI: −87.6 to −3.4, P for trend = 0.045) and a decrease in forced vital capacity (FVC) of −139.4 mL (95% CI: −223.5 to −55.4, p < 0.001) compared to those in the lowest quartile. …"

Table 1_Effects of honeycomb polysaccharides on growth performance, slaughter performance, antioxidant capacity, and immune function in Cyan-Shank Partridge chickens.docx حسب Haibo Zhang (5720)

"…Compared with those in NC group, there was a significant decrease (p < 0.05) in serum malondialdehyde and a significant increase (p < 0.05) in serum superoxide dismutase activity in group HPs1200. …"

<b>A meta-analysis of immediate and delayed discard mortality of red snapper (</b><b><i>Lutjanus campechanus</i></b><b>)</b> حسب Chloe Ramsay (21664871)

"…We found a significant positive relationship between depth and discard mortality and that, in the western Gulf, fishing in the summer significantly increases discard mortality compared to fishing in other seasons and regions. …"

Supplementary Material for: Metabolic analysis of three-dimensional cultured gastrointestinal cancer cells suggests that L-arginine inhibits tumor growth by affecting the urea cycl... حسب Tanaka E. (4127287)

"…Using OE33, carbamoyl aspartic acid (CAA) levels were significantly lower in arginine-treated than in untreated cells. …"