Image 8_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…The unexplored potential of chemical checkpoint inhibitors in rejuvenating immune responses prompted our investigation.</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Image 5_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…The unexplored potential of chemical checkpoint inhibitors in rejuvenating immune responses prompted our investigation.</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Data Sheet 2_Toxocariasis in children: seroprevalence after 15 years in a major city in Brazil.docx by Viviane dos Santos Vaccaro Lima (22644209)

“…As no mitigatory actions were carried out between the surveys, we speculate that environmental contamination and child exposure to Toxocara spp. remained steady. …”

Table 1_Magnesium application partially reversed the negative effects of mulching on rhizosphere nitrogen cycling in a Phyllostachys praecox forest.xlsx by Hong Zhao (325)

“…To address this, our study investigated rhizosphere nitrogen cycling in Lei-bamboo across a short-term degradation cycle. We found that mulching enhanced the abundance of 16S-rRNA and nitrogen-cycling functional genes. …”

Data Sheet 1_Toxocariasis in children: seroprevalence after 15 years in a major city in Brazil.pdf by Viviane dos Santos Vaccaro Lima (22644209)

“…As no mitigatory actions were carried out between the surveys, we speculate that environmental contamination and child exposure to Toxocara spp. remained steady. …”

Image 3_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…The unexplored potential of chemical checkpoint inhibitors in rejuvenating immune responses prompted our investigation.</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Table 1_Expansion of CD57+ CD8 T cells in common variable immunodeficiency with hepatopathy and CMV infection.pdf by Patrick Bez (13168041)

“…</p>Results<p>The expansion of CD57⁺ CD8 T cells was part of the previously described immune alteration, including altered CD4/CD8 ratio and a decrease in naïve CD4 T cells. The loss of significant association with increasing age might corroborate the suggestion of premature immunosenescence in CVID. …”

Image 9_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…The unexplored potential of chemical checkpoint inhibitors in rejuvenating immune responses prompted our investigation.</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

DataSheet1_Causal relationship between Women’s reproductive traits and postpartum depression: a multivariate mendelian randomization analysis.PDF by Zhen Kang (335450)

“…</p>Conclusion<p>The study indicates that AFB is a significant risk factor for PPD. Furthermore, the likelihood of developing PPD appears to decrease with increasing gestational age at the time of the first childbirth.…”

Table1_Causal relationship between Women’s reproductive traits and postpartum depression: a multivariate mendelian randomization analysis.XLSX by Zhen Kang (335450)

“…</p>Conclusion<p>The study indicates that AFB is a significant risk factor for PPD. Furthermore, the likelihood of developing PPD appears to decrease with increasing gestational age at the time of the first childbirth.…”

3D modelling of the impact of stellar activity on tidally-locked terrestrial exoplanets: atmospheric composition and habitability (dataset) by R Ridgway (9137141)

“…We find that coronal mass ejections abiotically generate significant levels of potential bio-signatures such as N2O. …”

sRAGE accelerates regeneration in aged skeletal muscle after cryoinjury. by Naftali Horwitz (3130086)

“…Dots represent data for individual animals overlaid with mean ±  SD. Data analyzed for statistical significance by one-way ANOVA with Tukey post hoc test (A, D, G) or Student’s two-tailed unpaired t test (E, H, J, K, L, M). …”

Thermodynamic properties of non-azeotropic refrigerant heat pumps under full operating conditions with non-phase-change heat sinks and heat soucres by Hemin Hu (21488860)

“…Additionally, the maximum temperature observed in the two-stage compression configuration was significantly lower compared to the regenerative setup. …”

In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma by Joaquín Yanes-Díaz (20539584)

“…EGFR and angiogenesis marker (Factor VIII) expression were significantly lower in the NP-427 group compared to other experimental groups. …”

Data Sheet 1_Exploratory study on the ascending pain pathway in patients with chronic neck and shoulder pain based on combined brain and spinal cord diffusion tensor imaging.docx by Zhiqiang Qiu (4603993)

“…</p>Results<p>Compared to HCs, CNSP patients showed decreased mean FA values and increased mean MD values in bilateral intracranial STT compared to the HC group, but two-sample t-test results indicated no statistically significant differences (p > 0.05). …”

Table1_Surviving septic patients endotyped with a functional assay demonstrate active immune responses.docx by Adam D. Price (19842741)

“…In contrast, TNF expression per cell on days 1, 4, and 7 was significantly lower in both septic and critically ill non-septic (CINS) patients compared to healthy subjects. …”

Image2_Surviving septic patients endotyped with a functional assay demonstrate active immune responses.jpeg by Adam D. Price (19842741)

“…In contrast, TNF expression per cell on days 1, 4, and 7 was significantly lower in both septic and critically ill non-septic (CINS) patients compared to healthy subjects. …”

Image3_Surviving septic patients endotyped with a functional assay demonstrate active immune responses.jpeg by Adam D. Price (19842741)

“…In contrast, TNF expression per cell on days 1, 4, and 7 was significantly lower in both septic and critically ill non-septic (CINS) patients compared to healthy subjects. …”

Image1_Surviving septic patients endotyped with a functional assay demonstrate active immune responses.jpeg by Adam D. Price (19842741)

“…In contrast, TNF expression per cell on days 1, 4, and 7 was significantly lower in both septic and critically ill non-septic (CINS) patients compared to healthy subjects. …”

Supplementary file 1_Influence of circadian rhythm on the determination of the IMMune age indeX (IMMAX).docx by Sina Trebing (22578458)

“…</p>Results<p>While individual immune cell ratios showed changes during the day, we determined no significant variability of the IMMAX score between the measurements. …”