Table 2_MIND diet score and its association with metabolic dysfunction-associated steatotic liver disease and gut microbiota profiles: a cross-sectional study.docx حسب Shengbo Yang (295144)

"…Inflammatory markers (CRP, LPS) decreased with higher adherence (all p < 0.001). Each 1-unit increase in MIND diet score was significantly associated with reductions in fasting insulin (β = −0.20 μU/mL; p < 0.001), HOMA-IR (β = −2.11; p < 0.001), CRP (β = −2.12; p < 0.001), LPS (β = −8.52; p < 0.001). …"

Data Sheet 1_Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics.docx حسب Tao Jiang (28401)

"…In addition, ATM significantly decreased the expression of TNF-α, IL-1β, IL-6, NF-κB and IL-17A, and significantly increased the level of IL-10 in diabetic mice. 16S rRNA sequencing and targeted GC-MS metabolomics result indicated that ATM restored gut microbiota dysbiosis based on increasing beneficial bacteria Lactobacillus and reducing pathogenic bacteria Helicobacter and Prevotella leading to the accumulation of propionic and valeric acids and the reduction of lipopolysaccharides (LPS) release, intestinal inflammation and intestinal barrier damage. …"

Table 6_Global, regional, and national burden of self-harm among adolescents aged 10-24 years from 1990 to 2021, temporal trends, health inequities and projection to 2041.xlsx حسب Jiang Tan (260415)

"…The High SDI region showed a slight upward trend in incidence, Southern Latin America experienced the largest increase, and the Middle SDI region showed the largest decrease. Conversely, East Asia demonstrated the most significant reductions in both incidence and mortality. …"

Table 7_Global, regional, and national burden of self-harm among adolescents aged 10-24 years from 1990 to 2021, temporal trends, health inequities and projection to 2041.xlsx حسب Jiang Tan (260415)

"…The High SDI region showed a slight upward trend in incidence, Southern Latin America experienced the largest increase, and the Middle SDI region showed the largest decrease. Conversely, East Asia demonstrated the most significant reductions in both incidence and mortality. …"

Table 4_Global, regional, and national burden of self-harm among adolescents aged 10-24 years from 1990 to 2021, temporal trends, health inequities and projection to 2041.xlsx حسب Jiang Tan (260415)

"…The High SDI region showed a slight upward trend in incidence, Southern Latin America experienced the largest increase, and the Middle SDI region showed the largest decrease. Conversely, East Asia demonstrated the most significant reductions in both incidence and mortality. …"

Table 3_Global, regional, and national burden of self-harm among adolescents aged 10-24 years from 1990 to 2021, temporal trends, health inequities and projection to 2041.xlsx حسب Jiang Tan (260415)

"…The High SDI region showed a slight upward trend in incidence, Southern Latin America experienced the largest increase, and the Middle SDI region showed the largest decrease. Conversely, East Asia demonstrated the most significant reductions in both incidence and mortality. …"

Table 5_Global, regional, and national burden of self-harm among adolescents aged 10-24 years from 1990 to 2021, temporal trends, health inequities and projection to 2041.xlsx حسب Jiang Tan (260415)

"…The High SDI region showed a slight upward trend in incidence, Southern Latin America experienced the largest increase, and the Middle SDI region showed the largest decrease. Conversely, East Asia demonstrated the most significant reductions in both incidence and mortality. …"

Table 1_Global, regional, and national burden of self-harm among adolescents aged 10-24 years from 1990 to 2021, temporal trends, health inequities and projection to 2041.xlsx حسب Jiang Tan (260415)

"…The High SDI region showed a slight upward trend in incidence, Southern Latin America experienced the largest increase, and the Middle SDI region showed the largest decrease. Conversely, East Asia demonstrated the most significant reductions in both incidence and mortality. …"

Table 2_Global, regional, and national burden of self-harm among adolescents aged 10-24 years from 1990 to 2021, temporal trends, health inequities and projection to 2041.xlsx حسب Jiang Tan (260415)

"…The High SDI region showed a slight upward trend in incidence, Southern Latin America experienced the largest increase, and the Middle SDI region showed the largest decrease. Conversely, East Asia demonstrated the most significant reductions in both incidence and mortality. …"

Data Sheet 1_Comprehensive analyses of immune activity in COVID-19-vaccinated idiopathic pulmonary fibrosis patients.docx حسب Agata Maciejewska (20523878)

"…Teffs in IPF patients showed a decrease in Th1-like and Th2-like populations after vaccination. …"

Table 1_Efficacy of submucosal administration of tramadol on acute pain following third molar surgery: a systematic review and meta-analysis.docx حسب Ahmad Salem Assari (20277900)

"…In addition, tramadol demonstrated a significant decrease in post-operative pain.</p>Conclusion<p>Submucosal tramadol is an efficient, safe, and dependable method for reducing post-operative acute pain, particularly in the first 6 h following impacted third molar surgery. …"

Supplementary file 1_The interaction between obesity and sex alters the response to house dust mite in an experimental model of allergic lung inflammation.docx حسب Amanda Santos-Cavalcante (22288645)

"…Additionally, it has been demonstrated that obesity is a significant predisposing factor for asthma, particularly among women. …"

Data Sheet 1_Vespa orientalis pupae peptide hydrolysates modulate NF-κB signaling in LTA-induced pneumonia from clinical Enterococcus faecalis isolates: implications for gut microb... حسب Mujeeb Ur Rahman (20445245)

"…Immune modulation was observed, with a decrease in pro-inflammatory cytokine levels, an increase in anti-inflammatory cytokine levels, and suppression of NF-κB signaling. …"

Image 3_Global trends of early-onset Parkinson’s disease from 1990 to 2021, and projections until to 2030: a systematic analysis of the global burden of disease study 2021.jpeg حسب Bingtao Hu (16784702)

"…The geographical disparities at regional and national level were evident. Significant disparities in EOPD burden by SDI were observed, exhibiting a worsening inequality over time. …"

Table 1_Impact of repeated in-vitro bacterial culture on virulence and antibiotic resistance characteristics: a study of Gram-positive and Gram-negative fish pathogens.docx حسب Angana Bag (21398267)

"…The results revealed a significant decrease in the virulence of Gram-positive pathogens. …"

Distribution patterns of Platycodon grandiflorus from the last inter-glacial period to the future by ecological niche modeling حسب Chunjiao Li (19159480)

"…The results indicated: (1) The species' distribution strongly correlates with environmental variables, particularly bio13, prec07, prec09 and tmin07, whose cumulative value of percent contribution was 78.5%; (2) The centroids of potential geographic distribution during the LIG, LGM, and MH periods were situated further westward compared tothe present distribution, with substantial contraction observed in highly suitable habitats throughout these historical periods; (3) Under present climatic conditions, the overall suitable habitat encompasses4,185,964 km2, withhighly suitable habitats constitutingone-third of this expanse, predominantlyconcentrated in central, southern, and northeasternChina; (4) Future climate change scenarios predict that the total suitable habitat will expand to varying degrees (7% increase on average), albeit with potential reductions in highly suitable areas (3% decrease on average); (5) The distribution of P. grandiflorus is likely to move towards higher latitudes in the future due to climate changes. …"

Image 2_Global trends of early-onset Parkinson’s disease from 1990 to 2021, and projections until to 2030: a systematic analysis of the global burden of disease study 2021.jpeg حسب Bingtao Hu (16784702)

"…The geographical disparities at regional and national level were evident. Significant disparities in EOPD burden by SDI were observed, exhibiting a worsening inequality over time. …"

Data Sheet 1_Urinary microbiota changes among NMIBC patients during BCG therapy: comparing BCG responders and non-responders.docx حسب Toni Boban (20852165)

"…Patient inclusion criteria were male gender, no previous history of urothelial cancer, no other malignancies, no active infection, and no antibiotic usage for at least 20 days before the first BCG dose. We observed a significant decrease in biodiversity, measured by the Shannon Index, during the first week of therapy in 10 out of 12 patients (p=0.021). …"

DataSheet1_Subsurface mesoscale eddies in the east of the Philippines: three-dimensional biogeochemical structures and transports.docx حسب Ya-nan Ding (12006089)

"…Regarding CHL transport in the euphotic zone, SSAE is the primary contributor, with a notable westward CHL transport observed in the study area, and mainly a northward transport occurring north of 12°N. …"

Image 4_Global trends of early-onset Parkinson’s disease from 1990 to 2021, and projections until to 2030: a systematic analysis of the global burden of disease study 2021.jpeg حسب Bingtao Hu (16784702)

"…The geographical disparities at regional and national level were evident. Significant disparities in EOPD burden by SDI were observed, exhibiting a worsening inequality over time. …"