Data Sheet 2_Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells.docx by Joshua Flynn (2544523)

“…</p>Methods<p>This study utilised a targeted single-cell multi-omics approach to characterise peripheral blood mononuclear cell (PBMC) populations and their transcriptomic profiles in an Irish cohort of people with (i) sepsis and (ii) bacteraemia without sepsis (defined as clinically significant positive blood culture without sepsis as assessed by the Clinical Microbiology service).…”

Data Sheet 1_Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells.docx by Joshua Flynn (2544523)

“…</p>Methods<p>This study utilised a targeted single-cell multi-omics approach to characterise peripheral blood mononuclear cell (PBMC) populations and their transcriptomic profiles in an Irish cohort of people with (i) sepsis and (ii) bacteraemia without sepsis (defined as clinically significant positive blood culture without sepsis as assessed by the Clinical Microbiology service).…”

Land Use Change Transfer Diagram. by Wanzhuang Huang (17357306)

“…The impact of road network density and river network density on the evolution of production-living-ecological land conflicts in the Shiyang River Basin was the most significant. The optimization results of national spatial patterns and regulation strategies could provide a scientific basis for the optimization and comprehensive management of national spatial planning in arid inland river basins.…”

Table 2_Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy.csv by N. J. L. Smeets (21188726)

“…Patients were defined as responder when aldosterone levels decreased after a single administration of enalapril. …”

Table 1_Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy.csv by N. J. L. Smeets (21188726)

“…Patients were defined as responder when aldosterone levels decreased after a single administration of enalapril. …”

Research framework. by Wanzhuang Huang (17357306)

“…The impact of road network density and river network density on the evolution of production-living-ecological land conflicts in the Shiyang River Basin was the most significant. The optimization results of national spatial patterns and regulation strategies could provide a scientific basis for the optimization and comprehensive management of national spatial planning in arid inland river basins.…”

Supplementary Tables S1 and S2 by Thomas Clanton (9323303)

“…Overall, the results are consistent with a significant early contribution of myeloid-derived, resident immune cells to the cytokine secretory responses in intact oxidative skeletal muscle.…”

Table 2_Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction.xlsx by Yan Du (229593)

“…Introduction<p>Metabolic and gut microbiota (GM) disturbance play a significant role in the complex pathogenesis of substance dependence. …”

The framework of this study. by Yin Yu (3139023)

“…The results show that (1) the landscape pattern changed visibly from 2000 to 2020, the comprehensive land-use dynamics increased from 8.53% to 9.66%, and the land use dynamics are greatest and change most dramatically on construction sites; (2) the landscape ecological risk level of the study area as a whole showed a declining trend, and 96.82% of the ecological risk plot index decreased, and the risk distribution was dominated by lower risk, medium risk and higher risk areas; (3) landscape ecological risk was spatially positively correlated across all time periods, and the spatial aggregation was gradually weakened, with the distribution of LH and HL areas dispersed and the distribution of HH and LL areas concentrated. …”

Table 1_Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction.xlsx by Yan Du (229593)

“…Introduction<p>Metabolic and gut microbiota (GM) disturbance play a significant role in the complex pathogenesis of substance dependence. …”

The effects of emotional expressivity and self-efficacy levels of individuals with substance addiction on treatment compliance by Murat Toprak (19853862)

“…</p> <p>In the present study, the emotional expressivity total score average of the participants was found to be 26.53 ± 9.03, their self-efficacy/sufficiency total score average was 74.15 ± 14.84, and their treatment compliance total score average was 85.27 ± 17.25. A negative and significant relationship was detected between the TCS total score and the EES total score of the participants, and there was a positive and significant relationship with the SES total score average (<i>p</i> < .05).…”

Data Sheet 1_Global burden of Type 2 Diabetes Mellitus attributable to dietary risks in elderly adults: insights from the Global Burden of Disease study 2021.docx by Yiting Tang (2295307)

“…Background<p>Type 2 Diabetes Mellitus (T2DM) poses a significant global health challenge, particularly among elderly adults. …”

Data_Sheet_1_Systematic analysis and prediction of the burden of lower respiratory tract infections attribute to non-optimal temperature, 1990–2019.docx by Yu Shi (117923)

“…BAPC model projections suggest a downward trend in the future burden of death and DALYs from the disease, but the improvement in the burden of death for women was not significant.…”

Key model formula. by Chayanit Mahasing (19688403)

“…In addition, we conducted a one-way sensitivity analysis by adjusting R0 from 1.8 to 3.0 in all scenarios (epidemic stage) and by decreasing the vaccination cost by 50% at the end of the first year to reflect the current policy direction to enhance domestic vaccine production. …”

Model framework. by Chayanit Mahasing (19688403)

“…In addition, we conducted a one-way sensitivity analysis by adjusting R0 from 1.8 to 3.0 in all scenarios (epidemic stage) and by decreasing the vaccination cost by 50% at the end of the first year to reflect the current policy direction to enhance domestic vaccine production. …”

Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes by Wen-Xia Yang (20485041)

“…Urinary Agt, Angiotensin II (Ang II) and oxidative stress were decreased in <a href="" target="_blank">Akita RT-<i>Agt</i>^<em>-/-</em> </a>mice cf. …”

Protocol for our RNA-seq. by Sabih Rashid (5618807)

“…GO enrichment was conducted using the Wormbase Gene Set Enrichment Analysis [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003144#pbio.3003144.ref046" target="_blank">46</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003144#pbio.3003144.ref047" target="_blank">47</a>]. …”

Essential model parameters. by Chayanit Mahasing (19688403)

“…In addition, we conducted a one-way sensitivity analysis by adjusting R0 from 1.8 to 3.0 in all scenarios (epidemic stage) and by decreasing the vaccination cost by 50% at the end of the first year to reflect the current policy direction to enhance domestic vaccine production. …”

Oxidative imbalance linked to impaired mitochondrial bioenergetics mediates the toxicity of mesoionic compounds MI-D and MI-J in hepatocarcinoma cells (HepG2) by Ana Paula Perbiche Neves (20978015)

“…MI-D in the HG medium decreased glutathione peroxidase (GPX) activity, whereas MI-J reduced the enzyme activity at a concentration of 25 μM and increased it at 50 μM. …”

Appendices. by Tingting Cui (564531)

“…The positive indicators have a spatial distribution that decreases from the northwest to the southeast, with the old city district having higher coefficients than the new city district. …”