Data Sheet 1_Rice glycosyltransferase OsDUGT1 is involved in heat stress tolerance by glycosylating flavonoids and regulating flavonoid metabolism.doc by Guang-rui Dong (11871026)

“…Correspondingly, the loss of OsDUGT1 function caused a significant decrease in endogenous flavonoid accumulation in rice, which was demonstrated by our metabolomics analysis. …”

Effect of different light conditions on the growth response of sugar beet to NaCl by Ryota Obama (20179531)

“…Furthermore, the growth promotion by NaCl accumulation was accompanied by a significant decrease in NO₃–N concentration, which suggested that NaCl application affects nitrogen metabolism in sugar beet.…”

DataSheet1_Analysis of the response to high temperature stress in hybrid grouper (Epinephelus fuscoguttatus♀×E. lanceolatus♂).zip by Yan Hu (30839)

“…However, they are susceptible to high temperatures, which can reduce disease resistance, slow growth rates, and decrease production efficiency, resulting in significant economic losses. …”

DataSheet1_Analysis of the response to high temperature stress in hybrid grouper (Epinephelus fuscoguttatus♀×E. lanceolatus♂).zip by Yan Hu (30839)

“…However, they are susceptible to high temperatures, which can reduce disease resistance, slow growth rates, and decrease production efficiency, resulting in significant economic losses. …”

Protein levels of Bcl-2 family markers in limbal stromal cells (LSCs) and in Aniridia-LSCs (AN-LSCs), after treatment with 0 µM, 50 µM and 75 µM Cobalt chloride (CoCl₂),... by Shanhe Liu (5251313)

“…<p>Data represent mean±SD from three independent experiments. Two-way ANOVA followed by Dunnett’s test was used, significant p values are indicated. …”

Table 1_Association of brain-derived neurotrophic factor in blood and cerebrospinal fluid with Parkinson’s disease and non-motor symptoms of Parkinson’s disease: a systematic revie... by Zhenzhen Zhao (782550)

“…A significant association was found between decreased serum BDNF concentrations and cognitive impairment in PD (SMD = −1.035; 95% CI [−1.340, −0.730]; P < 0.001). …”

Data Sheet 1_Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systemat... by Yuhua Jiang (10300159)

“…Moreover, the incidence of adverse events (AEs) was similar to that observed in the control group, which included both placebo and potent statin groups, with no significant differences identified in our study (P > 0.05).…”

Table 1_Housed feeding improves rumen health by influencing the composition of the microbiota in Honghe cattle.docx by Runqi Fu (15267554)

“…For rumen microbiota, the HES group significantly decreased alpha diversity. The core rumen bacterial communities were Bacteroidata, Firmicutes and Proteobacteria. …”

Data Sheet 1_Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics.docx by Tao Jiang (28401)

“…In addition, ATM significantly decreased the expression of TNF-α, IL-1β, IL-6, NF-κB and IL-17A, and significantly increased the level of IL-10 in diabetic mice. 16S rRNA sequencing and targeted GC-MS metabolomics result indicated that ATM restored gut microbiota dysbiosis based on increasing beneficial bacteria Lactobacillus and reducing pathogenic bacteria Helicobacter and Prevotella leading to the accumulation of propionic and valeric acids and the reduction of lipopolysaccharides (LPS) release, intestinal inflammation and intestinal barrier damage. …”

Data Sheet 2_Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.docx by Yi Kang (387134)

“…Subsequently, the two-step MR and multivariable MR (MVMR) were employed to examine whether any mediators causally mediated the observed associations.…”

Table 1_Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.xlsx by Yi Kang (387134)

“…Subsequently, the two-step MR and multivariable MR (MVMR) were employed to examine whether any mediators causally mediated the observed associations.…”

Data Sheet 1_Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.docx by Yi Kang (387134)

“…Subsequently, the two-step MR and multivariable MR (MVMR) were employed to examine whether any mediators causally mediated the observed associations.…”

Data Sheet 1_Comprehensive analyses of immune activity in COVID-19-vaccinated idiopathic pulmonary fibrosis patients.docx by Agata Maciejewska (20523878)

“…Teffs in IPF patients showed a decrease in Th1-like and Th2-like populations after vaccination. …”

Table 1_Efficacy of submucosal administration of tramadol on acute pain following third molar surgery: a systematic review and meta-analysis.docx by Ahmad Salem Assari (20277900)

“…In addition, tramadol demonstrated a significant decrease in post-operative pain.</p>Conclusion<p>Submucosal tramadol is an efficient, safe, and dependable method for reducing post-operative acute pain, particularly in the first 6 h following impacted third molar surgery. …”

Supplementary file 1_The interaction between obesity and sex alters the response to house dust mite in an experimental model of allergic lung inflammation.docx by Amanda Santos-Cavalcante (22288645)

“…Additionally, it has been demonstrated that obesity is a significant predisposing factor for asthma, particularly among women. …”

Data Sheet 1_Vespa orientalis pupae peptide hydrolysates modulate NF-κB signaling in LTA-induced pneumonia from clinical Enterococcus faecalis isolates: implications for gut microb... by Mujeeb Ur Rahman (20445245)

“…Immune modulation was observed, with a decrease in pro-inflammatory cytokine levels, an increase in anti-inflammatory cytokine levels, and suppression of NF-κB signaling. …”

Image 3_Global trends of early-onset Parkinson’s disease from 1990 to 2021, and projections until to 2030: a systematic analysis of the global burden of disease study 2021.jpeg by Bingtao Hu (16784702)

“…The geographical disparities at regional and national level were evident. Significant disparities in EOPD burden by SDI were observed, exhibiting a worsening inequality over time. …”

Table 1_Impact of repeated in-vitro bacterial culture on virulence and antibiotic resistance characteristics: a study of Gram-positive and Gram-negative fish pathogens.docx by Angana Bag (21398267)

“…The results revealed a significant decrease in the virulence of Gram-positive pathogens. …”

Distribution patterns of Platycodon grandiflorus from the last inter-glacial period to the future by ecological niche modeling by Chunjiao Li (19159480)

“…The results indicated: (1) The species' distribution strongly correlates with environmental variables, particularly bio13, prec07, prec09 and tmin07, whose cumulative value of percent contribution was 78.5%; (2) The centroids of potential geographic distribution during the LIG, LGM, and MH periods were situated further westward compared tothe present distribution, with substantial contraction observed in highly suitable habitats throughout these historical periods; (3) Under present climatic conditions, the overall suitable habitat encompasses4,185,964 km2, withhighly suitable habitats constitutingone-third of this expanse, predominantlyconcentrated in central, southern, and northeasternChina; (4) Future climate change scenarios predict that the total suitable habitat will expand to varying degrees (7% increase on average), albeit with potential reductions in highly suitable areas (3% decrease on average); (5) The distribution of P. grandiflorus is likely to move towards higher latitudes in the future due to climate changes. …”

Image 2_Global trends of early-onset Parkinson’s disease from 1990 to 2021, and projections until to 2030: a systematic analysis of the global burden of disease study 2021.jpeg by Bingtao Hu (16784702)

“…The geographical disparities at regional and national level were evident. Significant disparities in EOPD burden by SDI were observed, exhibiting a worsening inequality over time. …”