Overcoming the Limitations of Transition-Metal Catalysis in the Chemoenzymatic Dynamic Kinetic Resolution (DKR) of Atropisomeric Bisnaphthols by Kun Wang (134525)

“…Therefore, we developed an efficient DKR method to access chiral BINOLs from racemic derivatives under dual copper and enzyme catalysis. …”

Overcoming the Limitations of Transition-Metal Catalysis in the Chemoenzymatic Dynamic Kinetic Resolution (DKR) of Atropisomeric Bisnaphthols by Kun Wang (134525)

“…Therefore, we developed an efficient DKR method to access chiral BINOLs from racemic derivatives under dual copper and enzyme catalysis. …”

A Novel Type of PSMA-Targeting Ligands via β‑Branched Aromatic α‑Amino Acid Modification, Bearing Enhanced Tumor Targeting and Reduced Renal Toxicity by Zong-Xiao Liu (22177765)

“…With average renal uptake of less than 10%ID/g, as opposed to 25%ID/g for [⁶⁸Ga]Ga-<b>PSMA-617</b>, this substantial decrease in renal accumulation translates to a significantly improved safety profile by minimizing nephrotoxic risks. …”

A Novel Type of PSMA-Targeting Ligands via β‑Branched Aromatic α‑Amino Acid Modification, Bearing Enhanced Tumor Targeting and Reduced Renal Toxicity by Zong-Xiao Liu (22177765)

“…With average renal uptake of less than 10%ID/g, as opposed to 25%ID/g for [⁶⁸Ga]Ga-<b>PSMA-617</b>, this substantial decrease in renal accumulation translates to a significantly improved safety profile by minimizing nephrotoxic risks. …”

Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…After coincubation with edited CMCs, the proportions of CD8+CD69+ and CD8+CD44+ T cells significantly increase, while the proportion of CD4+Foxp3+ T_regs notably decreases, indicating the restoration of immune responses. …”

Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…After coincubation with edited CMCs, the proportions of CD8+CD69+ and CD8+CD44+ T cells significantly increase, while the proportion of CD4+Foxp3+ T_regs notably decreases, indicating the restoration of immune responses. …”

Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…After coincubation with edited CMCs, the proportions of CD8+CD69+ and CD8+CD44+ T cells significantly increase, while the proportion of CD4+Foxp3+ T_regs notably decreases, indicating the restoration of immune responses. …”

Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…After coincubation with edited CMCs, the proportions of CD8+CD69+ and CD8+CD44+ T cells significantly increase, while the proportion of CD4+Foxp3+ T_regs notably decreases, indicating the restoration of immune responses. …”

Summary of KEGG enrichment analysis. by Zeynab Hosseinpoor (19762319)

“…While the expression levels of <i>IRS2</i>, <i>FOXO1</i>, and <i>ERK2</i> (<i>MAPK1</i>) were significantly decreased, the <i>SERPINF1</i> gene exhibited high expression simultaneously. pAAV-delivered <i>MIR-96</i> had no adverse effect on the viability of human RPE cells. …”

<i>SLC2A2</i> is associated with IGF1R pathways differentiation. by Yejin Kim (740789)

Enrollment flow-chart. by Marco Carbonara (11483575)

Primer sequences for RT-qPCR. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

siRNA sequences and negative controls sequences. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

Antibodies used in the study. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

S1 Data - by Jan Willem Koten (17743224)

“…Moreover, it is unclear how within-subject time course reliability limits the robust detection of connectivity on the group level. We estimated connectivity from a working memory task. …”

Connectivity statistics. by Jan Willem Koten (17743224)

“…Moreover, it is unclear how within-subject time course reliability limits the robust detection of connectivity on the group level. We estimated connectivity from a working memory task. …”

Histogram of the area factorψ. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Raw dataset Fig. 6. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Effect of sample size on reproducibility. by Jan Willem Koten (17743224)

Effect of corrections on connectivity maps. by Jan Willem Koten (17743224)