Determinants of lipid lowering therapy intensification in very high risk patients with dyslipidaemia eligible for PCSK9 monoclonal antibodies: 1-year outcomes of the PERI-DYS study by Klaus G. Parhofer (12280424)

“…This suggests an underutilisation of available treatments, highlighting a gap in the management of high CV risk patients.…”

Formulation details for hybrid GNP–Ag nanofluids. by Athirah Najwa Zaaba (22559957)

“…The nanofluids were synthesized using a two-step method with Tween-80 surfactant to enhance dispersion stability. …”

Genotoxic Mechanisms of Erythrophleum suaveolens Stem Bark Extracts and Fractions in MCF-7 Breast Cancer Cells via Mitochondrial and Non-Mitochondrial Pathways by Lateef Sulaimon (21706283)

“…After 72 hours, ESSB-treated MCF-7 cells showed a significant (p < 0.05) increase in DNA fragmentation and comet tail DNA percentages (flavonoids induced a 1.21-fold increase in comet tail length). …”

CircFNDC3B inhibits vascular smooth muscle cells proliferation in abdominal aortic aneurysms by targeting the miR-1270/PDCD10 axis by Baoping Deng (9081380)

“…</i> Our findings revealed a significant upregulation of circFNDC3B expression in AAA clinical specimens compared to normal tissues. …”

Table 1_Screening and identification of the H1R antagonists from natural products by BODIPY FL histamine recognition and DPHD-anchored bombardment coupled with target cell extracti... by Xinqi Li (14029494)

“…Introduction<p>Histamine is an important mediator of allergy, and inhibiting its binding to H1 receptors (H1R) is a key method to alleviate allergic diseases. Natural products with anti-allergic properties are an important source of natural H1R antagonists.…”

Table 1_Real-world first-line serplulimab therapy for advanced esophageal cancer: effectiveness, safety, and clinical implications.docx by Fei Yan (128878)

“…Only two serious adverse events were reported (one hyperkalemia and one decreased white blood cell count).</p>Conclusion<p>This real-world study supports the effectiveness and safety of serplulimab-based regimens as a first-line treatment for patients with locally advanced or metastatic esophageal cancer, regardless of their diverse characteristics.…”

Table 1_Methodological approaches to survey complex ice cave environments - the case of Dobšiná (Slovakia).docx by Katarína Pukanská (20431835)

“…The study also detected dynamic changes, such as the widening of the ice tunnel by 20 cm in some sections, and a vertical ice wall in Ruffinyi’s Corridor showed localized volume losses up to 9 m³ (between 2018 and 2023). …”

Image 1_Safety assessment of temozolomidee: real-world adverse event analysis from the FAERS database.png by Yu Liu (6938)

“…Although temozolomidee has a certain efficacy in the treatment of brain malignancies, its numerous adverse effects (AEs) suggest that its safety needs to be thoroughly evaluated.…”

Effects of repeated intravenous esketamine administration on affective biases by Christine Reif-Leonhard (20516212)

“…Misclassifications of other emotions as sad also decreased (<i>p</i> = .035, d = −0.79), indicating a reduced response bias towards sadness. …”

Supplementary file 1_Roles of oral anticoagulant use on the risk of 28-day mortality and in-hospital mortality in patients with acute respiratory distress syndrome.docx by Jiayang Huang (17943998)

“…After adjusting for the respective confounding factors, the associations of Warfarin with decreased risk of 28-day and in-hospital mortality were not significant (P > 0.05).…”

DataSheet1_Anaerobic membrane bioreactor (AnMBR) with external ultrafiltration membrane for the treatment of sugar beet vinasse.PDF by Beatriz Egerland Bueno (20143764)

“…<p>Vinasse, a by-product of ethanol production, is generated at significant rates. …”

Supplementary materials for PhD thesis - "Understanding ⁴⁰Ar/³⁹Ar age variations in basaltic lavas" by Cramer-Lee Elizabeth (22048359)

“…Intra-lava variations of 10-20 Ma are observed. A criteria for assessing the reliability of an ⁴⁰Ar/³⁹Ar age is proposed to evaluate each ⁴⁰Ar/³⁹Ar age, which has decreased the inter-lava ⁴⁰Ar/³⁹Ar age variability. …”

Supplementary file 1_Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stroma... by Huijie Lai (22696685)

“…</p>Results<p>In ectopic endometria of AM, there was a significant increase in miR-21 mRNA expression as well as heightened activity within the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway. …”

Supplementary file 2_Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stroma... by Huijie Lai (22696685)

“…</p>Results<p>In ectopic endometria of AM, there was a significant increase in miR-21 mRNA expression as well as heightened activity within the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway. …”

Rht1 functions in cell cycle progression and modulates fluconazole susceptibility. by Ci Fu (148006)

“…<p><b>A)</b><i><i>Candida albicans</i></i> strains were sub-cultured to an OD₆₀₀ of 0.2 in YPD and grown at 30 °C for 4 h. …”

Data Sheet 1_Genome-wide association analysis of grain iron and zinc in rice grown under agroclimatic sites with contrasting soil iron status.pdf by Sonu (17999809)

“…Grain Fe content along with Zn is a major contemporary breeding objective in rice in order to tackle micronutrient deficiency. …”

Correlation between each MSTM and each generative parameter. by Fabiano Baroni (234173)

“…Correlation values that are not significant (at , uncorrected) are grayed-out. For each spike train family, MSTMs are ordered according to decreasing absolute values of correlation with the generative parameter that determines synchrony, which is shown in the top row. …”

H2AK119ub is depleted from facultative heterochromatin as the cerebellum matures. by Aditya Parmar (22331873)

“…<b>(D)</b> Volcano plot depicting H2AK119ub abundance, as detected in normalized CUT&RUN data from early and late cerebellum, within H3K27me peak regions identified by SEACR in the early cerebellum. The significance threshold was a p-value <0.05, as computed using edgeR [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011843#pgen.1011843.ref071" target="_blank">71</a>] and limma [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011843#pgen.1011843.ref072" target="_blank">72</a>] (n = 4). …”

Effect of hypoxia on hepatocyte injury in NAFLD model mice. by Meiyuan Tian (22311505)

“…<p>(A) Analysis of mitochondrial membrane potential in hepatocytes in vivo. …”

Image 2_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.tif by Helena Hernández-Cuervo (9956465)

“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1^−/− mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”