Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Table 1_Gut microbiota dysbiosis in ankylosing spondylitis: a systematic review and meta-analysis.docx by Qin-Yi Su (14188151)

“…In terms of specific microbial families, we observed a significant decrease in the abundance of Bifidobacterium (SMD = -0.42, 95% CI: -2.37, 1.52; P < 0.001), which is known for its beneficial effects on gut health. …”

Histopathology of spiral ganglion neurons in aged mice. by Yoshiaki Inuzuka (22386349)

“…The aged group shows a significant decrease in SGN density and SGN mitochondria number compared with the young group. …”

Table 1_Differential effects of prophylactic iron supplementation on physiological gestational anemia and post-IDA gestational anemia: a study based on a rat model.docx by Zelin Zhang (1563172)

“…Objective<p>To observe the effects of iron supplementation on a physiological pregnancy and on pregnancy following iron deficiency anemia (IDA) caused by low-iron diet.…”

Effects of injury on exploratory behavior. by Ella R. Dockendorf (21533334)

Table 1_A daily positive work reflection intervention for psychological distress among Chinese nurses: a pilot randomized controlled trial.docx by Li Zhang (8200)

“…</p>Conclusions<p>Results suggest that a daily positive work reflection intervention is a feasible and promising intervention for decreasing Chinese nurses' psychological distress. …”

Image 1_A comparison of clinical outcomes following kyphoplasty for osteoporotic compression fractures of the thoracic and lumbar spine: a systematic review and meta-analysis.jpeg by Michael R. Kann (22070273)

“…Across studies, the primary risk of bias was due to confounding variables, resulting in a serious risk of bias in 12 studies (48.0%).</p>Discussion<p>Kyphoplasty provides comparable outcomes in thoracic and lumbar VCFs, with no clinically significant differences in pain relief or procedural effectiveness. …”

Table 1_A comparison of clinical outcomes following kyphoplasty for osteoporotic compression fractures of the thoracic and lumbar spine: a systematic review and meta-analysis.docx by Michael R. Kann (22070273)

“…Across studies, the primary risk of bias was due to confounding variables, resulting in a serious risk of bias in 12 studies (48.0%).</p>Discussion<p>Kyphoplasty provides comparable outcomes in thoracic and lumbar VCFs, with no clinically significant differences in pain relief or procedural effectiveness. …”

Catalytic CO₂ Capture Performance of a MEA-EAE-DEEA Trisolvent in a Hot Silicon Oil-Based Pilot Plant by Yu Li (183836)

“…To implement an energy-efficient combination of CO₂ capture technology, the pilot plant studies were conducted in preparation of commercialization of CCUS demonstration plants, during which a set of specific amine blends with various catalytic packing was employed. …”

Deleterious Effects of a GAD65 Monoclonal Autoantibody on Islet Function by Christiane S. Hampe (248347)

“…<p dir="ltr">An intrinsic hallmark of Type 1 Diabetes is the correlation between appearance of autoantibodies directed against islet cell autoantigens with subsequent development of the disease. We recently studied effects of human monoclonal autoantibodies (mAb) derived from a pre-diabetic patient and demonstrated that a GAD65mAb penetrated and accumulated in beta cells and significantly reduced the insulin secretion rate (ISR). …”

Data Sheet 1_A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analy... by Jianyu Chen (2624254)

Data Sheet 1_From court to community: a cost–benefit evaluation of a community sports programme for Arab women in Israel's multiethnic context.docx by Limor Dina Gonen (14258380)

“…Gains in mental well-being were observed but did not reach statistical significance (p = 0.09). …”

Data Sheet 1_A circular tri-trophic system incorporating plants, fish, and insects turns waste into a resource: case study with the cultivation of cucumber.docx by Efi Levizou (21298322)

“…Conversely, CAP resulted in a decline in nutrient levels in irrigation water relative to HP and DCAP, which led to significantly decreased leaf concentrations of potassium and phosphorus (2.5 and 1.5 times lower than HP, respectively, by the end of the experiment). …”

Data Sheet 1_Preoperative geriatric nutritional risk index as a predictor of postoperative delirium in revision arthroplasty: a 10-year retrospective cohort study.docx by Xuming Chen (2404711)

“…</p>Conclusion<p>A significant association was observed between preoperative GNRI and POD in patients undergoing hip or knee revision arthroplasty. …”

Table 1_Efficacy and safety of combination of frankincense and botulinum toxin in the treatment of blepharospasm: a protocol for a single-centre, open-label, randomized, controlled... by Shiyuan Gong (22754579)

“…Symptom improvement is defined as a decrease of one point or more in the Jankovic Rating Scale severity score compared to baseline in patients with BSP. …”

Supplementary file 1_Phase angle as a predictor of prolonged length of hospital stay and adverse outcomes in elderly medical inpatients: a retrospective cohort study.docx by Jia Liu (41593)

“…Adverse event rates across the PhA tertiles (T1–T3) were 32.9%, 18.6%, and 5.6%, respectively, indicating a significant decrease in event incidence as PhA values increased. …”

Table 1_A population database analysis to describe the residual burden of varicella in Italy—a high vaccination coverage area—from 2004 to 2022.docx by Elisa Barbieri (115023)

“…In the Veneto Region, following the implementation of VV in 2006, the IR significantly decreased by 20.5 annually (95% CI: −23.4, −17.5), ranging from 50.2 per 1,000 person-years in 2006 to 1.2 per 1,000 person-years in 2022.…”

Data Sheet 1_Artificial intelligence–enhanced mapping of the international classification of functioning, disability and health via a mobile app: a randomized controlled trial.zip... by Zhandos Kurban (21985553)

“…A total of 185 adult inpatients (≥18 years) were randomized to either a control group using paper questionnaires or an experimental group using the MedQuest app. …”