Supplementary file 1_Characteristics, clinical evidence and implementation effects of conditional approvals for drugs in China, a pooled analysis from 2020 to 2023.docx by Li Yang (6520)

“…<p>In late 2019, the conditional approval process for drugs in China transitioned from a pilot project to a formal program. Our study comprehensively analyzed 103 conditional approvals (CAs) authorized by the National Medical Products Administration (NMPA) from 2020 to 2023, specifically focusing on their characteristics, clinical evidence, and implementation effects. …”

Data Sheet 1_Perceived benefits and barriers to the use of long-acting injectable antiretroviral treatment among adolescents and young people living with HIV in Western Kenya: qual... by Shukri A. Hassan (14245301)

“…Participants viewed LA ART as a welcome alternative to oral ART due to benefits like improved adherence, reduced pill burden, increased convenience, enhanced privacy, decreased stigma, lower risk of accidental disclosure, and convergence in using LA contraception. …”

Data Sheet 2_Perceived benefits and barriers to the use of long-acting injectable antiretroviral treatment among adolescents and young people living with HIV in Western Kenya: qual... by Shukri A. Hassan (14245301)

“…Participants viewed LA ART as a welcome alternative to oral ART due to benefits like improved adherence, reduced pill burden, increased convenience, enhanced privacy, decreased stigma, lower risk of accidental disclosure, and convergence in using LA contraception. …”

Table 1_Changes in self-reported alcohol consumption at high and low consumption in the wake of the COVID-19 pandemic: a test of the polarization hypothesis.docx by Alexander Tran (11038679)

“…It was hypothesized that the COVID-19 pandemic led to a polarization of drinking–that is, heavy drinkers increased their drinking, while light to moderate drinkers decreased their drinking. …”

Data Sheet 1_Endophytic and antagonistic Bacillus amyloliquefaciens 8SE-IF1-derived nanoparticles encumber phytopathogenic oomycetes, fungi, bacteria, and viruses with enhanced gro... by A. Mary Sharmila (21898730)

“…The water-diffusible extract (WDE) of Ba-8SE-IF1 significantly inhibited the mycelial growth of Pythium aphanidermatum (44.6%), Phytophthora nicotianae (60.1%), Fusarium oxysporum f. sp. lycopersici (65.5%), and Colletotrichum gloeosporioides (66.7%) in poisoned food assays; the growth of Ralstonia solanacearum and Xanthomonas campestris in the agar well method (inhibition zones of 20.25 mm and 28.52 mm, respectively); and decreased the symptoms produced by tomato spotted wilt virus (TSWV) in local lesion host (68.3%) and tomato leaf curl New Delhi virus (ToLCNDV) in tomato plants (66.1%). …”

Image1_Association between vitamin C intake and thyroid function among U.S. adults: a population-based study.tiff by Jie Wu (10038)

“…A high level of vitamin C intake is associated with a decreased in TT4 levels among American adults, and the association was more pronounced among subjects with lower alcohol consumption. …”

Table 1_Obstetric and perinatal outcomes in pregnancies conceived with donor versus partner sperm: a systematic review and meta-analysis.docx by Junjie Liu (193511)

“…For other outcomes, including gestational diabetes mellitus, ectopic pregnancy, placental abruption, placenta previa, large and small for gestational age, preterm birth, high and low birth weight, perinatal death, stillbirth, neonatal death, and congenital anomalies, no significant disparities were observed.</p>Conclusions<p>Donor sperm offers improved pregnancy outcomes for severe male infertility or paternally inherited genetic disorders but is linked to elevated risks of preeclampsia and pregnancy-induced hypertension. …”

Image 1_Clinical outcomes of an intelligent pressure-controlled disposable ureteroscope for Laser lithotripsy in renal stone surgery: a retrospective matched cohort study.tif by Zhong Lv (4568410)

“…The overall complication rate was significantly lower in the experimental group</p>Conclusions<p>The use of an intelligent pressure-controlled disposable ureteroscope with laser lithotripsy for upper urinary tract surgeries can effectively reduce postoperative inflammation indicators, decrease average hospital stay and renal pelvis pressure, and improve the initial and total stone clearance rates.…”

Image 2_Clinical outcomes of an intelligent pressure-controlled disposable ureteroscope for Laser lithotripsy in renal stone surgery: a retrospective matched cohort study.tif by Zhong Lv (4568410)

“…The overall complication rate was significantly lower in the experimental group</p>Conclusions<p>The use of an intelligent pressure-controlled disposable ureteroscope with laser lithotripsy for upper urinary tract surgeries can effectively reduce postoperative inflammation indicators, decrease average hospital stay and renal pelvis pressure, and improve the initial and total stone clearance rates.…”

Minigene assay of rare missense VUS in exon 10. by Elina Mercier (22311151)

“…All of the tested variants significantly increase exon 10 skipping except for c.1061T > C; p.Leu354Pro which decreased skipping. …”

Table 1_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.docx by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Table 5_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.docx by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Table 2_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.docx by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Table 4_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.docx by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Table 3_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.docx by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Data Sheet 1_Perceptions and needs of patients, caregivers and health professionals regarding an oncology community center: a qualitative study.pdf by Inbal Mitnik (21611342)

“…</p>Conclusion<p>The results indicate that the new OCC was perceived as a significant step in developing medical services, however the main concern was a decrease in the level of confidence due to its distance from the hospital. …”

Image 2_Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study.jpg by Lan Huang (11591)

“…In the BF group, only TNF-α expression demonstrated a significant increase (P < 0.01). The expression of occludin is significantly reduced in the F/P/BF group, with the most pronounced decrease observed in the P group (P < 0.01). …”

Image 3_Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study.jpg by Lan Huang (11591)

“…In the BF group, only TNF-α expression demonstrated a significant increase (P < 0.01). The expression of occludin is significantly reduced in the F/P/BF group, with the most pronounced decrease observed in the P group (P < 0.01). …”

Image 1_Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study.jpg by Lan Huang (11591)

“…In the BF group, only TNF-α expression demonstrated a significant increase (P < 0.01). The expression of occludin is significantly reduced in the F/P/BF group, with the most pronounced decrease observed in the P group (P < 0.01). …”

Image 4_Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study.jpg by Lan Huang (11591)

“…In the BF group, only TNF-α expression demonstrated a significant increase (P < 0.01). The expression of occludin is significantly reduced in the F/P/BF group, with the most pronounced decrease observed in the P group (P < 0.01). …”