Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Changes in bioimpedance by sex. by Domingos L. S. Rios (20496173)

“…Methods: This study was a retrospective cohort comparing exposure variables in a secondary data analysis with a pre-post treatment design. …”

Clinical and epidemiological characteristics. by Domingos L. S. Rios (20496173)

“…Methods: This study was a retrospective cohort comparing exposure variables in a secondary data analysis with a pre-post treatment design. …”

Changes in bioimpedance by age. by Domingos L. S. Rios (20496173)

“…Methods: This study was a retrospective cohort comparing exposure variables in a secondary data analysis with a pre-post treatment design. …”

S1 Data - by Domingos L. S. Rios (20496173)

“…Methods: This study was a retrospective cohort comparing exposure variables in a secondary data analysis with a pre-post treatment design. …”

Transcript response differences between T1R and LEP patients for GO terms, KEGG or Reactome pathways that showed significant enrichment for both the LEP and T1R groups. by Wilian Correa-Macedo (11813183)

“…<p>Immune response-linked terms for which the 5639 overlapping up-regulated DET presented in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0011866#pntd.0011866.g002" target="_blank">Fig 2D and 2E</a> were significantly enriched. …”

Cytochrome bd-II oxidase CyxA promotes the pathogenicity of <i>Klebsiella pneumoniae</i> by resisting oxidative stress by Xiao Xiao (99147)

“…Additionally, the expression levels of <i>cyxA</i> at 37°C and 41°C were significantly higher compared to 30°C, and the Δ<i>cyxA</i> strain exhibited significantly lower viable counts, elevated intracellular reactive oxygen species (ROS) levels, and decreased total antioxidant capacity (T-AOC) relative to WT at 37°C and 41°C. …”

Composition of experimental diets fed to cherry shrimp (<i>N</i>. <i>davidi</i> var. red) including varying concentrations of astaxanthin and <i>Bidens pilosa</i> extract over a 8-... by Wei-Wei Hou (3405947)

Superimposed structures of AKT2 native (green color) and mutant (red color) models to visualize the stereochemical conformation of wild type and mutant residues at (a) 274, (b) 265... by Sadia Afrin Runa (22504971)

Sequential viral infections in adult mice beginning at 8 weeks of age stimulates a subset of immune phenotypes. by Yuhao Li (1559569)

Estimating the transportation cost matrix from microstate joint probability of consecutive timesteps at rest. by Giacomo Barzon (19832364)

Genes correlated with SARS-CoV-2 viral load over time are similarly expressed in independent datasets of SARS-CoV-2 infected lung and upper airway cells. by Vasanthi Avadhanula (259546)

Differential gene sets associated with the transcriptional host response to SARS-CoV-2 infection across serially collected samples. by Vasanthi Avadhanula (259546)

Differential expression patterns and functional gene groups associated with SARS-CoV-2 infection of nose organoids. by Vasanthi Avadhanula (259546)

“…<b>(c)</b> Similar to part b, but for genes decreased with SARS-CoV-2 infection. <b>(d)</b> Selected significantly enriched GO terms ⁴¹ within the genes over-expressed with SARS-CoV-2 infection in HNO204 (p<0.05, t-test). …”

Differential expression patterns and functional gene groups associated with SARS-CoV-2 viral load across serially collected samples. by Vasanthi Avadhanula (259546)

Levels of antioxidant enzymes (A) Catalase, (B) Superoxide dismutase, (C) peroxidase. by Hammad Ismail (4227988)

UpSet plot summarising key differentially expressed gene trends and Gene ontology analysis of differentially expressed genes present only in extremely high viral load group. by Vasanthi Avadhanula (259546)

Demographic characteristics of the matched groups with good quality RNA sequencing data. by Vasanthi Avadhanula (259546)

Event-free survival analysis of microvascular outcome. by Clemens Plattner (21567706)

Event-free survival analysis of macrovascular outcome. by Clemens Plattner (21567706)