Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras by Charles W. Parry (20966154)

“…Here we report the discovery of a novel series of reversible inhibitors that bind in an enlarged version of the switch I–II pocket with nanomolar affinities. …”

Differentially used transcripts (DUT) for T1R and LEP groups suggest dysregulation of inflammatory circuitry in T1R. by Wilian Correa-Macedo (11813183)

“…Next, DUT with non-significant changes were assigned PΔ = 0. Given that no gene ontology (GO) or pathway enrichments were found, we searched the annotated function of each implicated gene in the GO, Reactome and KEGG databases. …”

Green Hydrogen Economy: Scenarios versus Technologies by Hua Fan (495346)

“…Our findings reveal that operational scenarios can reduce LCOH more significantly than technological improvements alone. …”

Recycled Phosphorus Bioamendments from Wastewater Impact Rhizomicrobiome and Benefit Crop Growth: Sustainability Implications at Water-Food Nexus by Peisheng He (4822398)

“…Biosolid augmentation significantly impacted the rhizomicrobiome with decreased biodiversity but higher activities with enriched taxa capable of utilizing various carbon sources. …”

¹⁷⁷Lu-Labeled Heterodimeric Agent with High Stability Targeting Neovascularization for Tumor Radioligand Therapy by Biao Yang (545048)

“…However, we observed that the NGR sequence of L6 was gradually rearranged to iso-DGR under alkaline conditions, resulting in decreased stability. …”

Characteristics of the population studied. by Diego Rafael Batista (19746556)

“…In this qualitative study among PrEP users, mostly MSM, we explored perceptions, knowledge, and access barriers. …”

Overview of the validated interview guide. by Diego Rafael Batista (19746556)

“…In this qualitative study among PrEP users, mostly MSM, we explored perceptions, knowledge, and access barriers. …”

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”

Unraveling the Mechanism of 1‑Deoxynojirimycin (DNJ) Accumulation: The Role of SWEET3 in Mulberry Chloroplasts by Zhen Yang (107412)

“…Transient overexpression or RNA interference of <i>SWEET3</i> in mulberry leaves significantly increased or decreased DNJ levels, respectively, while stable overexpression in hairy roots enhanced DNJ accumulation. …”

IFN-responsive and anti-viral pathways are induced in γδ T cells post-HIV-1 acquisition. by Gina L. Griffith (20649097)

Benchmark regression results. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Heterogeneity test. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

S1 File - by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

The robustness test. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Mechanistic testing. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Descriptive statistics of variables. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Endogenous treatment. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Analysis of industry linkage effects. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Analysis of peer effects. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Highly Sensitive and Selective Electrochemical Sensor via Cu-BTC/Au@Cu-BTC Modified Screen-Printed Electrode for the Detection of Chemical Agents by Xiaosen Li (6263651)

“…The peak current showed a good linear relationship with the concentrations of the three target substances, with <i>R</i>² values all greater than 0.99. …”