Image 4_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…MNAM increased SIRT1 protein levels in the cochlea without altering Sirt1 mRNA, suggesting post-transcriptional regulation. …”

The recruitment of Paf1C to the <i>frq</i> ORF is regulated by the WCC activity. by Mengmeng Zhou (9197699)

“…<p>(A) The enrichment of PAF-1 (Left) or RTF-1 (Right) at the <i>frq</i> ORF middle region significantly decreased in <i>wc-2</i>^<i>KO</i> strain at DD14. …”

SNAP-25 (1-197) binds to syntaxin-1A, and the interaction is enhanced by Ser187 phosphorylation. by Dilara Koc (22431017)

“…Data are representative of 3 independent experiments, and results are presented as mean ± SD. *: P ≤ 0.05; **: P ≤ 0.01; ***: P ≤ 0.001.…”

Table1_Trp-574-Leu and the novel Pro-197-His/Leu mutations contribute to penoxsulam resistance in Echinochloa crus-galli (L.) P. Beauv..docx by Penglei Sun (18343673)

“…Molecular docking studies revealed that Trp-574-Leu mutation primarily reduced the enzyme’s ability to bind to the triazole-pyrimidine ring of penoxsulam due to decreased π–π stacking interactions, while Pro-197-His/Leu mutations impaired binding to the benzene ring by altering hydrogen bonds and hydrophobic interactions. …”

Table 1_Prior Trichinella spiralis infection protects against Schistosoma mansoni induced hepatic fibrosis.docx by Asmaa M. El-kady (16502930)

“…Furthermore, pre- infection with T. spiralis markedly reduced S. mansoni- induced hepatic fibrosis, as evidenced by decreased collagen deposition, low expression of α-SMA, and significantly reduced levels of IL-17, IL-1B, IL-6, TGF-B, IL-23, and TNF-α compared to mice infected with S. mansoni only.…”

Table 1_GLP1 receptor agonists and SGLT2 inhibitors for the prevention or delay of type 2 diabetes mellitus onset: a systematic review and meta-analysis.docx by Farah Ghobar (22480732)

“…Moreover, HbA1c levels were assessed in seven studies, where significant reductions in treatment groups were reported with a standardized mean difference of -6.95 (95% CI: [-14.24, 2.98], p-value= 0.06) for the overall effect size. …”

Table 1_Research on the effect of Rosa roxburghii root in alleviating spleen and stomach damp–heat gastric ulcer by regulating the imbalance of oral–gut axis microbiota.xlsx by Jiangsong Cao (22580375)

“…</p>Results and discussion<p>Compared to the control (CON) group, the gastric ulcer (GU) group exhibited significant pathological alterations in the gastric mucosa. …”

Table 1_Integrated physiological and transcriptomic analyses elucidate the molecular mechanisms of exogenous melatonin-mediated salt tolerance in pomegranate (Punica granatum L.).x... by Yuanling Yang (22524785)

“…In contrast, 400 μM MT treatment effectively mitigated oxidative damage by coordinated activation of superoxide dismutase (SOD,+14.3%), peroxidase (POD,+21.7%), and catalase (CAT,+11.7%) activities, thereby stabilizing membrane integrity. Furthermore, MT significantly alleviated photoinhibition: F_V/F_M increased by 39%, Y_II and qP rose, and NPQ decreased compared to salt-stressed plants, reflecting enhanced protection of the PSII reaction center and optimized light energy allocation. …”

Image 1_Caffeine on the mind: EEG and cardiovascular signatures of cortical arousal revealed by wearable sensors and machine learning—a pilot study on a male group.jpeg by Shabbir Chowdhury (22246345)

“…Although systolic and diastolic BP showed a non-significant upward trend, HR decreased significantly after caffeine intake (77 ± 5.3 bpm to 72 ± 2.5 bpm, p = 0.027). …”

Supplementary file 1_Hydroxysafflor yellow A alleviates oxidative stress and inflammatory damage in the livers of mice with nonalcoholic fatty liver disease and modulates gut micro... by Liang Wu (131111)

“…</p>Results<p>HSYA significantly inhibited HFD-induced weight gain and alleviated liver inflammation. …”

DataSheet1_Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo.docx by Erwan Le Tallec (19834785)

“…</p>Results<p>Our results demonstrated that efferocytosis was significantly reduced in M0-MDMs from healthy donors exposed to the CXCL4-rich plasma of SSc patients. …”

Data Sheet 1_Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma.zip by Qiwei Zhao (12519351)

“…Furthermore, CAP increased levels of MDA, Fe²⁺, and ROS while decreasing GSH; these alterations were reversed by Fer-1 treatment. …”

Table 1_A species of Coprococcus is related to BMI in patients who underwent malabsorptive bariatric surgery and its abundance is modified by magnesium and thiamin intake.docx by Fernando Suárez-Sánchez (7552866)

“…The Shannon and Simpson diversity indices decreased significantly after surgery (p < 0.001). …”

Table 1_Pingwei Powder alleviates high-fat diet-induced colonic inflammation by modulating microbial metabolites SCFAs.xlsx by Tangjuan Liu (2634649)

“…Experimental validation showed that PWP significantly downregulated the levels of PI3K, pAKT/AKT, and pmTOR/mTOR in colonic tissue, thereby enhancing autophagy in colonic epithelial cells, as evidenced by decreased levels of P62 and increased LC3B-II/LC3B-I ratios. …”

Data Sheet 1_Prevalence trends, population characteristics and treatment outcomes of tuberculosis combined with diabetes in Southwest China: a register-based retrospective study.do... by Deliang Kong (382201)

“…PTB-DM patients were characterized by a higher proportion of males and older adult individuals, the age range of the patients was 11 ~ 100 years, with a mean age of 58.21 ± 12.02 years, with multiple positive aetiological results, and lower rates of proactive medical consultation. …”

<b>Targeted Metabolomic Profiling Reveals Inflammation – Associated longitudinal</b><b>changes in Plasma Metabolites Following on-pump Coronary Bypass Surgery</b> by Frieder Neu (18393729)

Evolutionarily conserved and functionally important amino acids in Artemis. by Ziwen Huang (17562948)

“…All flow cytometry data represented the mean ±  SD of three biological replicates. <i>P</i> values were analyzed with Student <i>t</i> test. ns, not significant.…”

Supplementary file 1_Transcriptome-wide N6-methyladenosinem modifications analysis of chicken cecum in responding to Campylobacter jejuni inoculation.zip by Yanan Zhao (3132906)

“…</p>Results<p>In the S group, the level of proinflammatory cytokines (IL-8, IL-1β, IL-18, TNF-α, IL-17A) and global RNA methylation were significantly decreased (P < 0.05). A total of 30,427 and 30,367 m⁶A peaks were identified in R and S groups, which were primarily located in 3'UTR and CDS regions. …”

The role of Cathepsin inhibitors in RGC damage in hypoxic retina. by Emi Nakajima (21703141)

“…Treatment with neither Odanacatib nor SID26681509 reduced the percentage of PI-positive RGCs, whereas the positive control SNJ-1945 significantly decreased the percentage. Data are means ± SD (n = 3). …”

The threshold effect analysis of the BRI on HGS. by Zhihao Wei (10909679)

“…Before this threshold, for every unit increase in BRI, HGS increases significantly (β = 2.19, 95% CI = 1.66, 2.72).</p><p>Conclusion</p><p>The results showed that BRI was positively correlated with HGS and negatively correlated with MQI, meaning that higher BRI was associated with higher HGS and lower MQI. …”