Discovery of <i>N</i>‑(1,3,4-Thiadiazol-2-yl)amide Derivatives as Uncompetitive Inhibitors of 6‑Phosphogluconate Dehydrogenase by Rong Zhang (44942)

“…Among them, <b>19n</b> exhibited significant potency against 6PGD with an IC₅₀ value of 5.1 ± 1.0 μM. …”

Experimental Analysis of Paraffin Deposition in Slug Flow by Aziz Alhejaili (10331604)

“…Paraffin (wax) deposition poses a significant challenge in oil and gas production, particularly in ultradeepwater and harsh environments where temperatures drop below the wax appearance temperature (WAT). …”

Experimental Analysis of Paraffin Deposition in Slug Flow by Aziz Alhejaili (10331604)

“…Paraffin (wax) deposition poses a significant challenge in oil and gas production, particularly in ultradeepwater and harsh environments where temperatures drop below the wax appearance temperature (WAT). …”

Experimental Analysis of Paraffin Deposition in Slug Flow by Aziz Alhejaili (10331604)

“…Paraffin (wax) deposition poses a significant challenge in oil and gas production, particularly in ultradeepwater and harsh environments where temperatures drop below the wax appearance temperature (WAT). …”

Identification of Key Genes. by Chen Wang (88408)

PDS and CEP inhibited DDX60-mediated promotion of CCHFV replication. by Yutong Sui (11151669)

Stop codon readthrough for tRNA modification gene deletion mutants. by Léo Hardy (22538036)

Predicted behavioural expression of young (orange) and old (blue) individuals that do (treatment) or do not (control) receive an immune challenge. by Antoine Bour (20489426)

“…<p>(a) If an immune challenge causes sickness behaviour then we expect that young and old immune-challenged individuals will decrease their population-level average behavioural expression compared with controls with old individuals decreasing their behavioural expression more than young individuals. …”

Source data file. by Laura Mora-Bitria (20477525)

“…Our results were validated in an independent data set. We conclude that iKIRs significantly decrease HLA class II protective associations and suggest that iKIRs regulate CD4⁺ T cell responses in T1D.…”

Supporting data file. by Laura Mora-Bitria (20477525)

“…Our results were validated in an independent data set. We conclude that iKIRs significantly decrease HLA class II protective associations and suggest that iKIRs regulate CD4⁺ T cell responses in T1D.…”

Demographics by Country and Gender. by Deeviya Francis Xavier (21485043)

“…Regarding creative self-efficacy, we found gender-specific impacts, with male participants experiencing a decrease, contrary to our expectations. …”

Study Data. by Deeviya Francis Xavier (21485043)

“…Regarding creative self-efficacy, we found gender-specific impacts, with male participants experiencing a decrease, contrary to our expectations. …”

Dataset. by Nathan Mubiru (21627195)

“…In contrast, samples collected in plain serum tubes kept at room temperature and uncentrifuged, C-peptide and insulin levels decreased significantly to 51% (p = 0.006) and 62% (p = 0. 083) respectively, similarly insulin levels for centrifuged samples declined to 64% (p = 0.083). …”

Complementary conditioning measures in healthy subjects. by Gabriela Ribeiro (4748373)

“…<b>(I) Novelty</b> ratings significantly decreased from pre to post-conditioning (F_(1,51) = 10.2, <i>P</i> = 0.002; post hoc CS^-, <i>P</i> = 0.0001; post hoc CS⁺, <i>P</i> = 0.01) but similarly for both stimuli (F_{(1, 51)} = 0.17, <i>P</i> = 0.7; Interaction: F_{(1, 51)} = 1.1, <i>P</i> = 0.3). …”

Cyclization Decoded: Engineering Amylomaltase for Efficient α‑Glucan Transformations by Han Liu (288039)

“…Furthermore, we identify that postglycosylation noncovalent polysaccharide chain transfer emerges as the decisive factor in cyclization, particularly for AM–degree of polymerization (DP) greater than 30 substrate complexes, where this noncovalent step (≥13.6 kcal/mol) dictates the rate of CA production. 57 variants with enhanced activity (up to a 2.3-fold increase) were engineered in our biochemical experiments by strategically modulating the chain transfer step. …”

Complementary conditioning measures across the clinical study groups. by Gabriela Ribeiro (4748373)

“…Post hoc tests showed significant decreases for the surgical group (<i>P</i> = 0.05), while in the remaining groups, results did not reach significance (Healthy, <i>P</i> = 0.4; Obese, <i>P</i> = 0.1). …”

Overview of annotated metabolites. by Yunfei Xu (3156420)

“…<div><p>Tea ranks among the top three most beloved non-alcoholic beverages worldwide and boasts significant economic and health benefits. In addition to <i>Camellia sinensis</i> (L.) …”

Population dynamics reflect intention-action binding. by Jean-Paul Noel (3072192)

Charge Delocalization for Electrically Detachable Poly(ionic liquids) Ionoadhesives with Ultrahigh Mechanical Robustness by Shijie Sun (9385097)

“…In addition, charge delocalization sharply decreases the escaping energy of mobile ions and thus significantly facilitates ion hopping. …”

Charge Delocalization for Electrically Detachable Poly(ionic liquids) Ionoadhesives with Ultrahigh Mechanical Robustness by Shijie Sun (9385097)

“…In addition, charge delocalization sharply decreases the escaping energy of mobile ions and thus significantly facilitates ion hopping. …”