ROS, K⁺ efflux and cathepsin B are required for NLRP3 activation. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

Ba/F3 EML4-ALK^mutants exhibit variable dose-response to ABT-199 treatment. by Richard Junior Zapata Dongo (17912565)

Mod loss is associated with a reduction of central brain NBs. by Amalia S. Parra (4173004)

The binding energy values of ATP, ALK inhibitors and ABT-199 to ALK were obtained from AlphaFold and modeled protein structures. by Richard Junior Zapata Dongo (17912565)

Anecdotal case of regression in a clam with naturally acquired BTN. by Rachael M. Giersch (22331947)

Negative (Prednisone) and basal (ATP) control compounds binding to ALK protein. by Richard Junior Zapata Dongo (17912565)

Regional Characteristics in Ultradeep MXene Slit Nanopores: Insights from Molecular Dynamics Simulation by Kaiqing Sun (18715965)

“…As the interlayer spacing varies, the ion distribution in the electrode pores exhibits regional characteristics: in the ordered region near the bulk region, a stable electrical double-layer (EDL) structure is maintained, whereas in the deeper mixed region, persistent co-ion presence and significant disorder are observed. Dominated by the mixed region, the total energy variation of the electrode decreases as the interlayer spacing decreases, with energy changes of 8526.52, 7443.52, and 6640.99 kJ·mol^–1 at interlayer spacings of 1.2, 1.0, and 0.8 nm, respectively, representing reductions of approximately 12.7 and 22.1% compared to 1.2 nm. …”

Regional Characteristics in Ultradeep MXene Slit Nanopores: Insights from Molecular Dynamics Simulation by Kaiqing Sun (18715965)

“…As the interlayer spacing varies, the ion distribution in the electrode pores exhibits regional characteristics: in the ordered region near the bulk region, a stable electrical double-layer (EDL) structure is maintained, whereas in the deeper mixed region, persistent co-ion presence and significant disorder are observed. Dominated by the mixed region, the total energy variation of the electrode decreases as the interlayer spacing decreases, with energy changes of 8526.52, 7443.52, and 6640.99 kJ·mol^–1 at interlayer spacings of 1.2, 1.0, and 0.8 nm, respectively, representing reductions of approximately 12.7 and 22.1% compared to 1.2 nm. …”

Regional Characteristics in Ultradeep MXene Slit Nanopores: Insights from Molecular Dynamics Simulation by Kaiqing Sun (18715965)

“…As the interlayer spacing varies, the ion distribution in the electrode pores exhibits regional characteristics: in the ordered region near the bulk region, a stable electrical double-layer (EDL) structure is maintained, whereas in the deeper mixed region, persistent co-ion presence and significant disorder are observed. Dominated by the mixed region, the total energy variation of the electrode decreases as the interlayer spacing decreases, with energy changes of 8526.52, 7443.52, and 6640.99 kJ·mol^–1 at interlayer spacings of 1.2, 1.0, and 0.8 nm, respectively, representing reductions of approximately 12.7 and 22.1% compared to 1.2 nm. …”

S1 Data - by Richard Junior Zapata Dongo (17912565)

“…This interaction was further supported by a significant decrease of ALK phosphorylation in single and combination treatment with 300nM ABT-199. …”

RNA targets of Mod identified by RiP-Seq. by Amalia S. Parra (4173004)

“…Mod is expressed in larval brains and its loss leads to a significant decrease in the number of central brain NBs. …”

The loss of NLRP3 and AIM2 results in reduced Th17 and enhanced Th2 cytokine responses. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

Egg-induced IL-1β and IL-17 production is dependent on both Caspase-1 and Caspase-8. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

<i>In vitro</i> characterization of the mnuA::Tn and 0690::Tn mutants. by Aga E. Gelgie (17661720)

ALKG1202R –ABT199 interactions. by Richard Junior Zapata Dongo (17912565)

ALKC1156Y –ABT199 interactions. by Richard Junior Zapata Dongo (17912565)

ALKL1196M –ABT199 interactions. by Richard Junior Zapata Dongo (17912565)

ALK^wt–ABT199 interactions. by Richard Junior Zapata Dongo (17912565)

ALK inhibitors (Positive control) and ABT199 (Proposed binding) in complex with the ALK active side. by Richard Junior Zapata Dongo (17912565)

BT9 exhibits a dose- and time-dependent cytotoxic effect on medulloblastoma. by Zahra Motahari (6814013)