Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …"

General experimental design. حسب Marion Hitier (21261938)

"…Results revealed a significant time effect for flexibility (p < 0.001). …"

Results of the two-way repeated measures ANOVA. حسب Marion Hitier (21261938)

"…Results revealed a significant time effect for flexibility (p < 0.001). …"

Scale scores of all participants. حسب Sylwia Sumińska (21169999)

"…However, a notable difference emerged between the two MBSR groups: in the group with smartwatches, a significant increase in mindfulness was observed. In contrast, in the MBSR group without smartwatches, there was a significant decrease across multiple stress-related components, including: anxiety, cognitive impairment, addictions, sleep disorders symptoms, behaviors indicating lack of entertainment, and poor functioning.…"

Raw data_clean. حسب Carlos Sepúlveda (15272797)

"…Conversely, being overweight or obese is associated with lower CRF, which can lead to decreased daily energy expenditure and reduced physical activity. …"

Experimental design. حسب Carlos Sepúlveda (15272797)

"…Conversely, being overweight or obese is associated with lower CRF, which can lead to decreased daily energy expenditure and reduced physical activity. …"

Characterization of the participants. حسب Carlos Sepúlveda (15272797)

"…Conversely, being overweight or obese is associated with lower CRF, which can lead to decreased daily energy expenditure and reduced physical activity. …"

Participants’ Mean Blood Glucose. حسب Giti Azim (20940548)

"…The finding of this study shows that total cholesterol and blood glucose increase in people of older age categories, married people, people with hypertension, overweight, and obesity; while decreases in people with higher education categories, people who always take salt, and people who do physical exercise.…"

Participants’ Mean Total Cholesterol. حسب Giti Azim (20940548)

"…The finding of this study shows that total cholesterol and blood glucose increase in people of older age categories, married people, people with hypertension, overweight, and obesity; while decreases in people with higher education categories, people who always take salt, and people who do physical exercise.…"

WGCNA as well as the co-expression network. حسب Hao Wang (39217)

"…<p>A: Module topology fit gradually increases with increasing soft threshold. B: Average connectivity gradually decreases with increasing soft threshold. …"

Fig. 2 Suppression of miRNA-21-5p ameliorates ovarian pathological alterations, hormonal imbalance, and insulin resistance in PCOS-IR rats. حسب 陈 晓红 (22613498)

"…(B) Silencing miRNA-21-5p significantly lowered serum luteinizing hormone (LH) levels in PCOS rats. …"

The basic flowchart of analysis in this study. حسب Jing Wang (6206297)

"…Finally, we discovered that the levels of <i>PDK1</i> expression in AD patients were remarkably upregulated, while <i>FDX1</i> and <i>GLS</i> were significantly decreased using qPCR.</p><p>Conclusion</p><p>This study examined changes in intercellular communication between immune cells in the peripheral blood and identified five novel feature genes associated with cuproptosis in AD patients. …"

The enriched GO terms of the 19 DECAGs. حسب Jing Wang (6206297)

"…Finally, we discovered that the levels of <i>PDK1</i> expression in AD patients were remarkably upregulated, while <i>FDX1</i> and <i>GLS</i> were significantly decreased using qPCR.</p><p>Conclusion</p><p>This study examined changes in intercellular communication between immune cells in the peripheral blood and identified five novel feature genes associated with cuproptosis in AD patients. …"

Primers of the tested genes. حسب Jing Wang (6206297)

"…Finally, we discovered that the levels of <i>PDK1</i> expression in AD patients were remarkably upregulated, while <i>FDX1</i> and <i>GLS</i> were significantly decreased using qPCR.</p><p>Conclusion</p><p>This study examined changes in intercellular communication between immune cells in the peripheral blood and identified five novel feature genes associated with cuproptosis in AD patients. …"

Summary of patient demographic characteristics. حسب Jing Wang (6206297)

"…Finally, we discovered that the levels of <i>PDK1</i> expression in AD patients were remarkably upregulated, while <i>FDX1</i> and <i>GLS</i> were significantly decreased using qPCR.</p><p>Conclusion</p><p>This study examined changes in intercellular communication between immune cells in the peripheral blood and identified five novel feature genes associated with cuproptosis in AD patients. …"

TAD boundary stability for different noise amplitudes for all chromosomes. حسب Lucas Hedström (21688891)

Early and progressive microstructural damage is present in Fabry disease. حسب Jacob W. Johnson (20172850)

"…Associations between age and fractional anisotropy (FA; e) and mean diffusivity (MD, f) demonstrate a decrease and increase, respectively in the Fabry cohort with similar trends in controls. …"

Adverse event list. حسب Stefan Halbherr (21353882)

"…No statistically significant improvements were seen in the Montreal Cognitive Assessment (MoCA) (mean decrease −0.73; 95% CI; −2.1, 0.62; <i>p</i> = 0.255), Epworth Sleepiness Scale (mean increase 0.09; 95% CI; −2.6, 2.8; <i>p</i> > 0.999), Beck Depression Inventory (BDI) (mean decrease −1.27; 95% CI; −3.8, 1.3; <i>p</i> = 0.257), and the Starkstein Apathy Scale (mean increase 0.36; 95% CI; −1.6, 2.4; <i>p</i> = 0.822). …"

Patient characteristics. حسب Stefan Halbherr (21353882)

"…No statistically significant improvements were seen in the Montreal Cognitive Assessment (MoCA) (mean decrease −0.73; 95% CI; −2.1, 0.62; <i>p</i> = 0.255), Epworth Sleepiness Scale (mean increase 0.09; 95% CI; −2.6, 2.8; <i>p</i> > 0.999), Beck Depression Inventory (BDI) (mean decrease −1.27; 95% CI; −3.8, 1.3; <i>p</i> = 0.257), and the Starkstein Apathy Scale (mean increase 0.36; 95% CI; −1.6, 2.4; <i>p</i> = 0.822). …"