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Comparative transcriptomics reveals RhoE as a novel regulator of actin dynamics in bone-resorbing osteoclasts
Published 2014“…We then performed two-step differential transcriptomic profiling of bone-resorbing OCs versus nonresorbing MGCs to generate a list of genes implicated in bone resorption. …”
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Comparative Analysis of Preterm and Full-term Births using Transcriptomic Profiling
Published 2025“…On the other hand, homeostatic regulators <i>IL10</i> (interleukin 10)and <i>TGFBR2</i> (transforming growth factor beta receptor 2) demonstrated down regulation portraying an imbalance of immune homeostasis. …”
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Transcriptomic Analyses of Myeloid-Derived Suppressor Cell Subsets in the Circulation of Colorectal Cancer Patients
Published 2020“…We have recently reported the transcriptomic profiles of tumor-infiltrating MDSCs in CRC patients and uncovered pathways, which could potentially assist tumor progression. …”
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Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data
Published 2020“…<p dir="ltr">According to publicly available transcriptome datasets, the abundance of Annexin A3 (ANXA3) is robustly increased during the course of sepsis; however, no studies have examined the biological significance or clinical relevance of ANXA3 in this pathology. …”
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Transcriptome analysis of Escherichia coli K1 after therapy with hesperidin conjugated with silver nanoparticles
Published 2021“…Backgrounds: Escherichia coli K1 causes neonatal meningitis. Transcriptome studies are indispensable to comprehend the pathology and biology of these bacteria. …”
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Transcriptome and Literature Mining Highlight the Differential Expression of ERLIN1 in Immune Cells during Sepsis
Published 2021“…This highly variable disease affects 19 million people globally, and accounts for 5 million deaths annually. In transcriptomic datasets curated from public repositories, we observed a consistent upregulation (3.26–5.29 fold) of ERLIN1—a gene coding for an ER membrane prohibitin and a regulator of inositol 1, 4, 5-trisphosphate receptors and sterol regulatory element-binding proteins—under septic conditions in healthy neutrophils, monocytes, and whole blood. …”
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Comprehensive Transcriptomic Profiling of Murine Osteoclast Differentiation Reveals Novel Differentially Expressed Genes and LncRNAs
Published 2021“…We compared the total RNA-based transcriptomes of murine bone marrow derived cells with differentiated osteoclasts, while focusing on potentially novel genes and LncRNAs, to uncover critical genes and their associated pathways, which are differentially regulated during osteoclast differentiation. …”
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Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19
Published 2020“…A number of upstream regulators (IFNG, PRL, TLR7, PRL, TGM2, TLR9, IL1B, TNF, NFkB, IL1A, STAT3, CCL5, and others) were also enriched in BAL cells from severe COVID-19-affected patients compared to those from patients with mild COVID-19. …”
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Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression
Published 2021“…Fascin, an actin bundling protein, was identified as a key regulator of many signaling pathways that contribute to breast cancer progression. …”
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Uhrf1 regulates adipogenesis through GPNMB mediated TGFBeta axis
Published 2023“…Uhrf1 is a key epigenetic regulator that coordinates DNA methylation and histone modifications; however, the function of Uhrf1 in metabolic diseases is not known. …”
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Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer
Published 2020“…However, limited data are available on phenotypic/transcriptomic characteristics of the different MDSCs subsets in cancer. …”
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Transcriptome profiling and network enrichment analyses identify subtype-specific therapeutic gene targets for breast cancer and their microRNA regulatory networks
Published 2023“…Network analysis identified complex miRNA-mRNA regulatory networks in each BC molecular subtype, in highvslow grade tumors, in tumors from young vs old patients, and in tumors from MENA <i>vs </i>non-MENA, thus implicating miRNA-mediated gene regulation as an essential mechanism in shaping the transcriptome of BC. …”
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Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism
Published 2022“…We examined the implicated signaling pathways using comparative transcriptomics in a cell model of steatosis to overcome pleiotropy. …”
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Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation
Published 2019“…Transcriptomic data was associated with marked reduction in SMAD2 protein phosphorylation, which thereby implies the inactivation of TGFβ and BMP signaling in those cells. …”
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The multiomics analyses of cancer stem cells isolated from solid tumors can provide insight for their immunological characterization.
Published 2023“…</p> <p>Objective: The aim of this study is to identify the molecular mechanisms regulating the immunological properties of cancer stem cells (CSCs) isolated from colorectal cancer (CRC) and breast cancer (BC) using integrative approaches including flow cytometry, miRNAs and RNA seq-based transcriptomic profile and in vitro functional assays.…”
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Transcriptomic Profiling of Tumor-Infiltrating CD4<sup>+</sup>TIM-3<sup>+</sup> T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Pa...
Published 2020“…<p dir="ltr">T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME). …”
